Hyperuricemia and Raised Atherogenic Index of Plasma is Associated with Hypertension

Abstract

Among the non-communicable diseases, CVD is the number one cause of mortality all over the world. Hypertension is an important contributor to cardiovascular diseases, stroke and kidney diseases. The study was done to evaluate the association of serum uric acid and atherogenic index of plasma with hypertension. A total of 100 individuals were selected as study subjects based on predefined enrollment criteria. Among them 50 diagnosed cases of hypertension were selected as cases and 50 normotensive healthy individuals as controls. Serum uric acid and serum lipid profile were measured in all study subjects. Atherogenic index of plasma was calculated by the formula log (TG/HDL-C). The study population mostly belonged to 36 to 45 years of age group. The mean age of hypertensive patients was 40.78±4.00 years and that of controls was 39.58±4.12 years. The study found that the mean levels of serum TG (205.24±56.74 mg/dl), TC (225.44±60.67 mg/dl), LDL-C (134.34±49.58 mg/dl) in hypertensive patients were significantly higher than those of controls. The mean AIP in the hypertensive patients was (0.68±0.19) significantly higher (p<0.001) than that of controls (0.43±0.22). The mean serum uric acid level in hypertensive patients (7.05±1.31 mg/dl ) was found to be significantly higher (p<0.001) than that of controls (4.84±1.27 mg/dl). The study shows a positive linear correlation of serum uric acid with TG (r=0.455, p=0.001), TC (r=0.504, p=0.001), LDL-C (r=0.425, p=0.002) and negative correlation with HDL-C (r= - 0.158, p=0.274) in hypertensives. The hypertensive subjects showed a positive significant (r= 0.437, p= 0.002) correlation between AIP and serum uric acid. From the study it seems that hyperuricemia and high AIP are associated with hypertension.Bangladesh J Med Biochem 2016; 9(1): 5-10