Hyperuricemia Associated with Low Skeletal Muscle in the Middle-Aged
                    and Elderly Population in China

Chen, Lingyan; Wu, Li; Li, Qian; Hu, Yu; Ma, Hui; Hao, Lin; Gao, Xin

doi:10.1055/a-1785-3729

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Additionally, skeletal muscle mass and strength play a role in SUA metabolism. Skeletal muscle is a major site of purine metabolism, and higher muscle mass in males leads to increased purine turnover and SUA production 34 . This, combined with higher testosterone levels, contributes to the higher SUA levels in males.…”

Section: Discussionmentioning

confidence: 99%

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

Zhao,

Zhang,

Chu

et al. 2023

Sci Rep

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The aim of this study was to explore the relationship between serum uric acid (SUA) and the triglyceride-glucose (TyG) index, which is a more effective indicator of insulin resistance. The study participants included 1700 children and adolescents with short stature who were recruited at the Affiliated Hospital of Jining Medical University in China between March 2013 and April 2021. A positive association between SUA levels and the TyG index was detected by univariate analysis (p < 0.001). Furthermore, a nonlinear relationship was detected between SUA and the TyG index, whose point was 6.55 mg/dL. There was a positive association between SUA and the TyG index when the SUA level was greater than 6.55 mg/dL (β 0.17, 95% CI: 0.07, 0.27; P < 0.001). However, we did not observe a significant relationship between SUA and the TyG index when the SUA level was less than 6.55 mg/dL (β 0.02, 95% CI: − 0.01, 0.05; P = 0.091). In addition, a stratified analysis was performed to appraise changes in this relationship for different sexes. The relationship between SUA and the TyG index in males and females is consistent with that in the general population, showing a nonlinear relationship. However, the inflection points of SUA level were significantly higher in males than in females, and the inflection points were approximately 6.72 and 5.88 mg/dL, respectively. This study revealed a nonlinear relationship between SUA and the TyG index in children with short stature. The nonlinear relationship remained in gender stratification analysis, but the inflection point of SUA level was higher in men. Further studies are needed to establish a causal relationship between SUA levels and the TyG index in children with short stature.

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Section: Discussionmentioning

confidence: 99%

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

Zhao,

Zhang,

Chu

et al. 2023

Sci Rep

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“…Many investigations have substantiated the adverse influence of adipose tissue on hyperuricemia [ 14 , 15 ]. However, it must be acknowledged that there may also be some degree of association between muscle tissue and serum uric acid (SUA) levels, a relationship confirmed by Chen et al [ 16 ]. Exploring the correlation between adipose tissue and hyperuricemia in isolation may be confounded by other tissues in the body composition, especially muscle tissue.…”

Section: Introductionmentioning

confidence: 98%

L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study

Li,

Shao,

Zhong

et al. 2024

Lipids Health Dis

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Background Insufficient attention has been given to examining the correlation between body composition and hyperuricemia, leading to inconsistent findings. The primary objective of this research is to explore the association between lean body mass index (LMI), visceral fat mass index (VFMI), and hyperuricemia. A specific emphasis will be placed on assessing the link between the ratio of lean body mass to visceral fat mass (LMI/VFMI) and hyperuricemia. Methods The present study employed a cross-sectional design and involved a total of 9,646 individuals who participated in the National Health and Nutrition Examination Survey (NHANES). To explore the associations among the variables, logistic and linear regressions were employed. Additionally, subgroup analyses and sensitivity analyses were conducted based on various characteristics. Results The results showed that LMI was positively associated with hyperuricemia (for Per-SD: OR = 1.88, 95%CI: 1.75, 2.01; for quartiles [Q4:Q1]: OR = 5.37, 95%CI: 4.31, 6.69). Meanwhile, VFMI showed a positive association with hyperuricemia (for Per-SD: OR = 2.02, 95%CI: 1.88, 2.16; for quartiles [Q4:Q1]: OR =8.37, 95%CI: 6.70, 10.47). When considering the effects of In LMI/VFMI, an L-shaped negative association with hyperuricemia was observed (for Per-SD: OR = 0.45, 95%CI: 0.42, 0.49; for quartiles [Q4:Q1]: OR = 0.16, 95%CI: 0.13, 0.20). Subgroup and sensitivity analyses demonstrated the robustness of this association across different subgroups. Additionally, the segmented regression analysis indicated a saturation effect of 5.64 for the In LMI/VFMI with hyperuricemia (OR = 0.20, 95%CI: 0.17, 0.24). For every 2.72-fold increase of In LMI/VFMI, the risk of hyperuricemia was reduced by 80%. Conclusion The LMI/VFMI ratio is non-linearly associated with serum uric acid. Whether this association is causal needs to be confirmed in further longitudinal studies or Mendelian randomization.

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“…The number of patients with HUA in China exceeded 17 million in 2017, and the data shows a rapid increase in cases, with an annual growth rate of 9.7%. Gender, age, race, and lifestyle habits all affect the incidence of HUA ( Lanaspa et al., 2011 ; Chen et al., 2022 ; Maruhashi et al., 2022 ; Tsai et al., 2022 ; Yu et al., 2022 ). The key cause of primary HUA is a combination of low UA excretion and high UA production.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic and transcriptomic exploration of the uric acid-reducing flavonoids biosynthetic pathways in the fruit of Actinidia arguta Sieb. Zucc.

et al. 2022

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Flavonoids from Actinidia arguta Sieb. Zucc. can reduce uric acid in mice. However, the molecular basis of its biosynthesis is still unclear. In this paper, we used a combination of extensively targeted metabolomics and transcriptomics analysis to determine the types and differences of flavonoids in the fruit ripening period (August to September) of two main cultivated varieties in northern China. The ethanol extract was prepared, and the potential flavonoids of Chrysin (Flavone1), Rutin (Flavone2), and Daidzein (Flavone3) in Actinidia arguta Sieb. Zucc. were separated and purified by HPD600 macroporous adsorption resin and preparative liquid chromatography. The structure was identified by MS-HPLC, and the serum uric acid index of male Kunming mice was determined by an animal model test.125 flavonoids and 50 differentially regulated genes were identified. The contents of UA (uric acid), BUN (urea nitrogen), Cr (creatinine), and GAPDH in mouse serum and mouse liver glycogen decreased or increased in varying degrees. This paper reveals the biosynthetic pathway of uric acid-reducing flavonoids in the fruit of Actinidia arguta Sieb. Zucc., a major cultivar in northern China, provides valuable information for the development of food and drug homologous functional foods.

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Hyperuricemia Associated with Low Skeletal Muscle in the Middle-Aged and Elderly Population in China

Cited by 5 publications

References 46 publications

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study

Metabolomic and transcriptomic exploration of the uric acid-reducing flavonoids biosynthetic pathways in the fruit of Actinidia arguta Sieb. Zucc.

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