Hyperuricemia, Cardiovascular Disease, and Hypertension

Kuwabara, Masanari

doi:10.1159/000443769

Cited by 133 publications

(115 citation statements)

References 36 publications

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“…Before fasting uric acid level of 5.7 ± 0.3 mg/dl decreased by approximately 0.5 mg/dl during the study. Excess uric acid has adverse endothelial effects, but acts also as a reducing substance [45][46][47][48][49]. In our study, the acid uric levels remained within the 4.5 mg/dl to 6.2 mg/dl (or 6.0 mg/dl in the NHANES III cohort [46]) range where the J curve which relates uric acid concentrations to cardiovascular disease is flat [47,48].…”

Section: Microvascular Functionsupporting

confidence: 47%

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Esmaeilzadeh¹,

Borne²

2016

Biol Med (Aligarh)

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Background: Reduced endothelial nitric oxide bioavailability, a hallmark of endothelial dysfunction, is commonly encountered in cardiovascular diseases. Intermittent fasting reduces serum markers of oxidative stress, while nitric oxide levels may rise. Whether this translates into persistent improvements in endothelial function is unknown. The aim of the study was to address the effects of intermittent «Ramadan-type» fasting on endothelial function, nitric oxide bioavailability, biological parameters and blood pressure.

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Section: Microvascular Functionsupporting

confidence: 47%

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Esmaeilzadeh¹,

Borne²

2016

Biol Med (Aligarh)

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“…The antioxidant activity of uric acid is not powerful when compared with hydrophilic vitamin C or hydrophobic vitamin E, based on its chemical structure . Moreover, elevated serum uric acid level is associated with OS and the risk of hypertension, diabetes, and cardiovascular disease . In this way, the function of uric acid in the human body is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Effects of pre‐ or post‐exercise whey protein supplementation on oxidative stress and antioxidant enzymes in older women

Nabuco

Tomeleri

Fernandes

et al. 2019

Scandinavian Med Sci Sports

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Background Oxidative stress is an imbalance between antioxidant system and production of free radicals and has been associated with the age‐related deleterious changes. The defense system can be modulated by exercise and nutrition. Objective The purpose of this investigation was to evaluate the effect of whey protein supplementation pre‐ or post‐resistance training on oxidative stress and antioxidant enzyme activity in pre‐conditioned older women. Methods In a randomized, double‐blind, and placebo‐controlled design, 70 older women (≥60 years) were randomly assigned to one of the following three groups: whey protein‐placebo (WP‐PLA, n = 24), placebo‐whey protein (PLA‐WP, n = 23), and placebo‐placebo (PLA‐PLA, n = 23). Each group received 35 g of whey product or placebo pre‐ and post‐training. The RT program was carried out over 12 weeks (3x/week; 3x 8‐12 repetitions maximal). Oxidative stress and blood markers were assessed before and after intervention period. ANOVA for repeated measures was used for data analysis. Results There was a significant time effect (P < 0.05), with all groups showing improvements in all oxidative stress markers and antioxidant enzyme activity. A significant (P < 0.001) interaction time vs group was observed for uric acid, with both WP‐PLA and PLA‐WP presenting greater reductions compared with the PLA‐PLA, without differences between the timing of protein intake (WP‐PLA: −8.3%; PLA‐WP: −11.0%; PLA‐PLA:‐2.0%). Conclusion In already pre‐conditioned older women, whey protein supplementation reduces plasma uric acid concentration with no further effect on antioxidant enzyme activity and oxidative stress markers. ClinicalTrials.gov: NCT03247192.

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“…15 However, compared to men, SUA levels are lower in women. 16 Thus, we defined hyperuricemia in women as ≥6.0 mg/dL as is commonly used in other study populations. 17-20 HT was defined as the subjects who had current antihypertensive medication and/or systolic blood pressure (BP) of ≥140 mmHg and/or diastolic BP of ≥90 mmHg according to the Japanese Society of Hypertension guidelines (JSH 2014).…”

Section: Methodsmentioning

confidence: 99%

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases

et al. 2017

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Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic hyperuricemia and cardiometabolic conditions. Subjects consisted of Japanese adults between 30 and 85 years of age were enrolled in the study at Center for Preventive Medicine, St. Luke's International Hospital, Tokyo, and available at enrollment (2004) and at 5-year follow-up (2009). Subjects were excluded if they were overweight or obese, hypertensive, diabetic, dyslipidemic, had a history of gout or hyperuricemia on medications, or if they had chronic kidney disease as estimated glomerular filtration rate <60 ml/min/1.73m2. Linear and logistic regression analyses were used to examine the relationship between hyperuricemia and development of hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and overweight/obesity (unadjusted and adjusted for age, sex, smoking, drinking habits, baseline estimated glomerular filtration rate and body mass index). 5,899 subjects without comorbidities (mean age of 47 ± 10 years, 1,864 men) were followed for 5 years. Hyperuricemia (defined as >7 mg/dL in men and ≥6 mg/dL in women) was associated with increased cumulative incidence rates of hypertension (14.9% vs 6.1%, p<0.001), dyslipidemia (23.1% vs 15.5%, p<0.001), chronic kidney disease (19.0% vs 10.7%, p<0.001), and overweight/obesity (8.9% vs 3.0%, p<0.001), while diabetes mellitus (1.7% vs 0.9%, p=0.087) showed a trend but did not reach statistical significance. In conclusion, asymptomatic hyperuricemia carries a significant risk for developing cardiometabolic conditions in Japanese individual without comorbidities.

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Hyperuricemia, Cardiovascular Disease, and Hypertension

Cited by 133 publications

References 36 publications

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Does Intermittent Fasting Improve Microvascular Endothelial Function in Healthy Middle-aged Subjects?

Effects of pre‐ or post‐exercise whey protein supplementation on oxidative stress and antioxidant enzymes in older women

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases

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