Hyperuricemia in systemic lupus erythematosus: is it associated with the neuropsychiatric manifestations of the disease?

Sheikh, Mahdi; Movassaghi, Shafieh; Khaledi, Mohammad; Moghaddassi, Maryam

doi:10.1016/j.rbre.2015.07.011

Cited by 15 publications

(16 citation statements)

References 22 publications

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“…Because early intervention on LN improves long-term survival and kidney damage [11], it is important to predict renal damage early. The prevalence of hyperuricemia in SLE patients is reported to be approximately 16.1% [12] and 29% [13]. In LN patients with CKD stages prevalence of hyperuricemia in SLE patients is reported to be approximately 16.1% [12] and 29% [13].…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Choi

Kim

et al. 2020

JCM

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Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

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Section: Introductionmentioning

confidence: 99%

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Choi

Kim

et al. 2020

JCM

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“…Serum uric acid levels were investigated in various rheumatic diseases [6][7][8][9][10][11]15]. Choe et al [6] studied SUA levels in RA patients and it's association between inflammatory markers such as ESR and CRP in 23 patients treated with methotrexate (MTX) and 27 patients treated with MTX and leflunomide.…”

Section: Discussionmentioning

confidence: 99%

“…SUA levels with inflammatory markers was not found. Sheikh et al [7] detected hyperuricemia in 16.1% of 204 SLE patients and found that hyperuricemia was associated with the occurrence of stroke, peripheral neuropathy, hypertension, hyperlipidemia, and history of arterial thrombosis. Also, SUA levels were studied in psoriasis patients [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

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Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs

Sargın

Gürer

Bozbaş

et al. 2019

The European Research Journal

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Objectives: Uric acid has an important role in the production of various inflammatory cytokines such as tumor necrosis factor-α (TNF-α). Although serum uric acid levels in various rheumatic diseases have been performed the relationships between serum uric acid levels with inflammatory markers and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores in ankylosing spondylitis patients treated with anti-TNF-α and nonsteroid anti-inflammatory drugs (NSAIDs) have not been described yet. The aim of this study was to compare the relationships between serum uric acid levels, inflammatory markers and BASDAI scores in ankylosing spondylitis patients treated anti-TNF-α and NSAIDs. Methods: A total of 132 ankylosing spondylitis patients fulfilling the 1984 Modified New York Criteria who had serum uric acid, erythrocyte sedimentation rate and C-reactive protein levels in medical records were included in this retrospective cross-sectional study. Patients were divided in two groups (anti-TNF-α and NSAIDs). Their files were examined in detail. Later demographic and laboratory features were recorded to the research form. Results: Serum uric acid levels were significantly lower in the anti-TNF-α group (mean: 4.9 mg/dL, range: 4.10-5.45 mg/dL) than in the NSAIDs group (mean: 5.20 mg/dL, range 4.70-5.90 mg/dL) (p = 0.021). Also, positive correlations were found between C-reactive protein (p = 0.003) and BASDAI (p = 0.009) with serum uric acid. Conclusions: According to this study, we can consider that serum uric acid level could be used as an inflammatory laboratory marker, such as C-reactive protein in ankylosing spondylitis patients. However, we believe that more studies are needed about this research.

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“…Sheikh i wsp. wykazali, że hiperurykemia u chorych na SLE była istotnie związana z występowaniem udaru i neuropatii obwodowej, niezależnie od nadciśnienia i hiperlipidemii [58], natomiast Sabio i wsp. udowodnili związek pomiędzy podwyższonymi stężeniami kwasu moczowego, homocysteiny i sztywnością tęt-nic, co może wpływać na szybszy rozwój miażdżycy u tych chorych [59].…”

Section: Kwas Moczowy a Choroby Tkanki łąCznejunclassified

Effects of hyperuricemia on the skin

Owczarczyk‐Saczonek¹,

Krajewska–Włodarczyk²,

Placek³

2017

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StrESzczEniEKwas moczowy jest końcowym produktem metabolizmu puryn, a jego stężenie w surowicy u osób zdrowych wynosi 3-7 mg/dl. Hiperurykemia wiąże się z wyższym ryzykiem wystąpienia incydentów sercowo-naczyniowych, a wzrost stężenia kwasu moczowego, zależny od nieprawidłowych nawyków żywieniowych, jest charakterystyczny dla populacji krajów wysoko rozwiniętych. Hiperurykemia może prowadzić do pojawiania się na skórze różnych zmian chorobowych. Jednocześnie kwas moczowy jest ważnym przeciwutleniaczem, odpowiedzialnym za 2/3 pojemności antyoksydacyjnej organizmu. W pracy przedstawiono zmiany skórne towarzyszące dnie moczanowej (guzki dnawe, "dna prosówkowa", dnawe zapalenie tkanki podskórnej). Dokonano także przeglądu piśmiennictwa i omówiono znaczenie hiperurykemii w łuszczycy. Świadomość i wiedza dermatologów na temat hiperurykemii może wpłynąć na szybsze rozpoznawanie zaburzeń metabolicznych u pacjentów na podstawie oceny skóry. AbStrActUric acid is a final product of purine metabolism, and its concentration in the blood serum of healthy individuals is 3-7 mg/dl. Hyperuricemia is associated with higher cardiovascular risk, and its prevalence related to nutrition profile is characteristic for highly developed societies. It can lead to the appearance of certain skin lesions. On the other hand, uric acid is an important antioxidant, which is responsible for 2/3 of the antioxidant capacity of the body. In this article, the authors present skin lesions associated with gout (tophi, "miliarial gout", gouty panniculitis) and review the data of the literature and discuss the importance of hyperuricemia in psoriasis. Dermatologists' awareness and knowledge about hyperuricemia may favor a faster diagnosis of this metabolic disorder based on skin lesions. WPrOWAdzEniEKwas moczowy (ang. uric acid -UA) jest końco-wym produktem metabolizmu puryn pochodzących z diety, syntezy de novo oraz rozpadu komórek. Puryny są rozkładane przez szereg enzymów, tworzą ksantynę i hipoksantynę, które następnie są utleniane przez oksydazę ksantynową do kwasu moczowego. Stężenie kwasu moczowego w surowicy u osób zdrowych wynosi 3-7 mg/dl (180-420 µmol/l) i jest

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Hyperuricemia in systemic lupus erythematosus: is it associated with the neuropsychiatric manifestations of the disease?

Cited by 15 publications

References 22 publications

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Association between serum uric acid and inflammation markers in ankylosing spondylitis patients treated with tumor necrosis factor-α or nonsteroidal anti-inflammatory drugs

Effects of hyperuricemia on the skin

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