Hyperuricemia is associated with androgenetic alopecia in men: A cross‐sectional case‐control study

Abstract

Background Early androgenetic alopecia (AGA) is patterned hair loss occurring before 30 years. Early AGA is frequently reported in men and carries the risk of obesity, metabolic syndrome, and cardiovascular diseases. Hyperuricemia used to be a minor component of metabolic syndrome. Recently, increasing number of studies has proved that hyperuricemia is an independent risk factor for many cardiovascular diseases and psoriasis. However, none of these studies have examined the relationship between hyperuricemia and AGA. Aims To determine the association between hyperuricemia and AGA in men. Methods A cross‐sectional case‐control study was conducted. The medical charts and photographs of men with a clinical diagnosis of AGA were reviewed. The clinical and laboratory data of AGA and control groups were compared. Results Men with AGA (n = 1312) had higher mean uric acid level (6.25 mg/dL vs 5.97 mg/dL; P < .001) and higher prevalence of hyperuricemia (25.0% vs 15.6%; P < .001) than those without AGA (n = 2624). There was no statistically significant association between AGA severity and hyperuricemia (P = .295). Conclusions Men with early AGA have a higher prevalence of hyperuricemia.

Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults

“…Finally, hyperuricemia is an undesirable condition that has been seen as a minor trait of metabolic syndrome, cardiovascular risk, as well as other types of disorders such as psoriasis and alopecia, which have been associated with high levels of blood uric acid ( Guo et al , 2020 ; Ma et al , 2020 ; Talebi et al ., 2020 ; Zhang et al , 2020a ). Even though our criterion for hyperuricemia were defined as blood uric acid >6 mg/dL for women and 7 mg/dL for men, cut-off points could be reconsidered according to the considerations made by Alegría-Díaz et al (2018) .…”

Is early onset androgenetic alopecia related to hyperuricemia? A case control study

“…Based on a similar study (4) where the mean± standard deviation was 6.25 ± 1.27 and 5.97 ± 1.15 mg/dl respectively for the case and control group with p<0.001 we calculated the sample size of 104 each in the case and control groups to be necessary for power of 0.8 and α of 0.05.…”

“…Numerous studies have found early-onset AGA to be related with systemic disorders such as obesity (2), hypertension (3), cardiovascular diseases (2) and metabolic syndrome (4).…”

“…Early onset AGA has also been linked to hyperuricemia (a metabolic disorder characterised by elevated levels of serum uric acid) but has been explored inadequately (4)(5). Hyperuricemia (HU) is considered present if serum uric acid (the end product of purine metabolism) level exceeds 7 mg/dL (6).…”

Alopecia and Clinical Presentation of Endocrinopathies: Pathogenetic and Diagnostic Aspects

“…В 2020 году JingwenMa c соавторами в перекрестном исследовании случай-контроль показали следующие результаты: мужчины с АГА (n=1312) имели более высокий средний уровень мочевой кислоты (6,25 мг/дл против 5,97 мг/дл; р <0,001) и более высокую распространенность гиперурикемии (25,0% против 15,6%; р <0,001), чем без АГА (n=2624). Статистически значимой связи между тяжестью AГА и гиперурикемиейне продемонстрировано (р=0,295) [56].…”