Hyperuricemia Is Independently Associated with Coronary Heart Disease and Renal Dysfunction in Patients with Type 2 Diabetes Mellitus

Abstract

AimsTo investigate the relationship between hyperuricemia (HUA) and the clinical backgrounds in Japanese patients with type 2 diabetes mellitus.MethodsAfter a cross-sectional study evaluating the association of HUA with the clinical characteristics in 1,213 patients with type 2 diabetes mellitus, the estimated glomerular filtration rate (eGFR) and the incidence of diabetic macroangiopathies was investigated in a prospective observational study in 1,073 patients during a 3.5 year period. HUA was defined by serum uric acid levels >327 μmol/L or as patients using allopurinol.ResultsThe frequency of HUA was significantly higher in the diabetic patients (32% in men and 15% in women) than in the normal controls (14% in men and 1% in women). In total, HUA was found in 299 (25%) of the patients during the cross-sectional study. Even after adjusting for sex, drinking status, treatment for diabetes mellitus, body mass index, hypertension, use of diuretics, hyperlipidemia, HbA1c and/or the eGFR, the HUA was independently associated with some diabetic complications. The eGFR was significantly reduced in HUA patients compared to those with normouricemia in the 12 months after observation was started. HUA was also an independent risk factor for coronary heart disease even after adjustment in the Cox proportional hazard model.ConclusionsHUA is a associated with diabetic micro- and macroangiopathies. HUA is a predictor of coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus. However, the influence of HUA is considered to be limited.

Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

“…Hence, the variations in uric acid level may be due to gender-dependent differences in the range of uric acid. The overall prevalence of hyperuricemia is 28% which is comparable with the results obtained by a study conducted in Nigeria who reported the prevalence rate to be 25% [7] and also with a study conducted by Ito H. in Japan who reported the prevalence to be 25% (9).Hyperuricemia in diabetes mellitus II is also shown by other various studies [16,17,18].In contrast to these findings, some researchers have also shown negative association between uric acid and diabetes. Cook et al explained higher mean serum uric acid values in prediabetic patients than in recently diagnosed diabetics and lower values in diabetics.…”

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

“…In another study from Japan including 1213 type 2 diabetic patients, a positive independent association among HUA, coronary heart disease, and renal dysfunction was reported, supporting the hypothesis that HUA is implicated in the pathogenesis of the micro-and macrovascular diabetic complications. 69 In accordance, Tanaka et al 70 reported that HUA was correlated with increased risk of macrovascular disease in diabetic CKD patients.…”

Behavior of the total antioxidant status in a group of subjects with metabolic syndrome

“…A relationship between hyperuricemia and various MS components (hypertension, obesity, diabetes mellitus) has been demonstrated [36][37][38][39] and serum uric acid levels seem to be clearly associated with the prevalence of MS [36] and the incidence of DM [40]. In addition, in type 2 diabetic subjects hyperuricemia is correlated with the vascular complications, such as retinopathy, cerebrovascular and coronary artery diseases, and nephropathy [41].…”