2018
DOI: 10.1017/ice.2017.280
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Hypervirulent Clostridium difficile Strain Has Arrived in Brazil

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Cited by 14 publications
(6 citation statements)
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“…1c), only a single amino acid substitution of Asp7Glu (caused by a nucleotide T21G substitution), which was located outside of the three predicted domains [34], was found in 232 amino acids among both strains. Moreover, we did not detect an 18-bp deletion or a single-bp deletion at position 117, or a 39-bp deletion in tcdC as previously reported [3, 10, 11, 33, 35, 36]. On the other hand, we found that the tcdC sequences of ST67 strains (20100502, Lei034, F314, 5550, 51680, FD094, and FD109), except for strain LIBA5757 [10], were 100% identical to that of B18-123 (Fig.…”
Section: Resultssupporting
confidence: 82%
“…1c), only a single amino acid substitution of Asp7Glu (caused by a nucleotide T21G substitution), which was located outside of the three predicted domains [34], was found in 232 amino acids among both strains. Moreover, we did not detect an 18-bp deletion or a single-bp deletion at position 117, or a 39-bp deletion in tcdC as previously reported [3, 10, 11, 33, 35, 36]. On the other hand, we found that the tcdC sequences of ST67 strains (20100502, Lei034, F314, 5550, 51680, FD094, and FD109), except for strain LIBA5757 [10], were 100% identical to that of B18-123 (Fig.…”
Section: Resultssupporting
confidence: 82%
“…Similar to the present report, the majority of previous Brazilian studies failed to detect RT027 or RT078 in humans (Balassiano et al, 2009;Balassiano et al, 2011;Monteiro et al, 2014;Silva et al, 2015;Cançado et al, 2018). So far, RT027 was only recently reported in two patients from a hospital in the south Brazilian region, one of which was classified into ST67 (Pires et al, 2018). There is also a description of a clade 2 strain in a hospital in the northeast region of Brazil (Costa et al, 2016).…”
supporting
confidence: 89%
“…The absence or rare isolation of both RT027 and RT078 contrasts with reports in North America and most European countries but is consistent with previous studies reported in China that have suggested the emergence of other potentially epidemic genotypes of C. difficile, including strains from clade 3 [11]. To date, RT106 and 014/020 have been identified as the most frequent C. difficile strains in both humans and animals in Brazil [9,10,12,13], whereas RT027 has only been described in two individuals in the southern region of Brazil [14]. In contrast, the circulation of novel isolates from clade 2 in hospitals in Brazil poses a risk of emergence and spread of new epidemic strains, such as the recently reported RT181 in Greece [9,[15][16][17].…”
Section: Introductionsupporting
confidence: 89%
“…RT027 was not detected in samples from both animals and humans in Brazil. So far, it has been reported only in two individuals in 2018 in Southern Brazil [14]. However, typical clade 5 strains (RT078 and RT126) were detected in two patients (2.7%) but corresponded to more than 60% of the animal isolates in the present study.…”
Section: Plos Onecontrasting
confidence: 62%