Hyperviscosity in Whole Blood, Plasma, and Aqueous Humor Decreased by Doxium (Calcium Dobesilate) in Diabetics with Retinopathy and Glaucoma: A Double-Blind Controlled Study

Abstract

50 patients with diabetes mellitus of 2–7 years’ duration were divided by a random method into 2 equal groups, one of which received 1,500 mg of Doxium (calcium dobesilate) daily for 3 months, the other group receiving a placebo. All the patients had diabetic retinopathy, open-angle glaucoma, raised intraocular pressure, and hyperviscosity of whole blood, plasma, and aqueous humor. 10 patients in each group underwent operation for glaucoma. At the end of the trial the state of the retina, the visual acuity, and the visual fields had improved, and the intraocular pressure and the 3 viscosity values had fallen to a statistically significant extent in the Doxium group compared with the initial status and with the placebo group. These results are consistent with Doxium’s known action in reducing capillary fragility, microvascular hyperpermeability, and blood viscosity.

Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis

“…Two of the eight studies showed that elevated IOP can be significantly reduced [20,24]. However, more detailed information such as if eye drops were used to control IOP was not provided; furthermore, a large, multi-center study is warranted to confirm the conclusion.…”

“…Study type Randomization Blinding Lost to follow up Jadadscore Larsen et al [19] RCT 1 2 1 4 Vojnikovic et al [20] RCT 1 2 1 4 Leite et al [21] RCT 2 2 1 5 Benarroch et al [22] RCT 1 2 1 4 Vojnikovic et al [23] RCT 1 2 1 4 Benarroch et al [24] RCT 1 2 0 3 Ribeiro et al [25] RCT 1 2 1 4 Javadzadeh et al [26] RCT 2 2 0 4 a) DB, double blinding; RCT, randomized clinical trial; estimated effects of calcium obesilate on study characteristics, independent comparisons only (n=8). …”

Calcium Dobesilate in Prevention and Treatment of Diabetic Retinopathy

“…Evaluation by clinical examination, fluorescein angiography, angiography, and fundus photography failed to demonstrate any beneficial effect of calcium dobesilate (Stamper et al, 1978). On the other hand, the study with 50 patients who had diabetic retinopathy openangle glaucoma, raised intraocular pressure, and hyperviscosity of whole blood, plasma, and aqueous humor and received 1,500 mg of calcium dobesilate daily for 3 months or pacebo exhibited the significant improvement of the state of the retina, the visual acuity, the intraocular pressure and the 3 viscosity values in the calcium dobesilate group (Vojnikovic, 1984). In a retrospective controlled study, 54 patients with diabetic retinopathy received calcium dobesilate (mean 650 mg/day) for 6-30 months (mean 18 months) and were compared to a correspondingly selected control group.…”

Calcium Dobesilate versus Cabergoline for Prevention of Ovarian Hyper Stimulation Syndrome

“…It appeared in very low concentration in maternal milk. No pharmacokinetic interactions have been reported in the literature [35].…”