Hypnic headache: Response to lamotrigine in two cases

Abstract

To our knowledge, the response to lamotrigine in HH cases has never been reported. Because of its safety profile and availability, lamotrigine can be an effective alternative treatment in HH.

Case Report: Coexistence of SUNCT and Hypnic Headache in the Same Patient

“…4 Lamotrigine (LTG) is the most effective prophylaxis in SUNCT and it has been also reported to be effective in two patients with HH at the dose of 50 and 75 mg/day. 10 In our patient, LTG was clearly effective at the dosage of 100 mg/day. When HH developed, the patient was already receiving LTG 100 mg/day.…”

“…Caffeine is the drug of choice in HH and it is also effective when HH develops with other primary headaches . Lamotrigine (LTG) is the most effective prophylaxis in SUNCT and it has been also reported to be effective in two patients with HH at the dose of 50 and 75 mg/day . In our patient, LTG was clearly effective at the dosage of 100 mg/day.…”

Long‐Term Outcomes and Clinical Characteristics of Hypnic Headache Syndrome: 40 Patients Series From a Tertiary Referral Center

“…Other medications that were not tried in our study, but have shown some effectiveness in case reports are onabotulinumtoxinA, hypnotics (doxylamine succinate, diphenhydramine, eszopiclone), and lamotrigine …”

“…Other medications that were not tried in our study, but have shown some effectiveness in case reports are onabotulinumtoxinA, 36 hypnotics (doxylamine succinate, diphenhydramine, eszopiclone), 37 and lamotrigine. 38 In light of the above, we feel that caffeine is a reasonable first line treatment option for HH, due to ease of use and a more benign side effect profile than any of the prescription medications, including lithium.…”

Hypnic Headache Due to Hypoglycemia: A Case Report

“…Among the many reported cases of HH, some had type 2 diabetes mellitus as co‐morbidity . However, in none of these patients was hypoglycemia responsible for the onset of pain.…”