Hypnotics and antihistamines : effects ono cognitive functions and driving performance

Abstract

Pharma B.V. and Organon Nederland B.V. for publication of this dissertation is also gratefully acknowledged. Contents Chapter 1 General introductionAdverse effects of medicinal drugs on performance Hypnotics and antihistamines Assessing drug induced impairment of driving Aim of this dissertation Outline of this dissertation Chapter 2 Methodological guidelines for experimental research in Drugs and Driving: accomplishments and future needs Chapter 3 Residual effects of hypnotics: epidemiology and clinical implications Abstract -Tolerance Clinical implications and concluding remarks Chapter 4 Acute effects of zolpidem and flunitrazepam on sleep, memory and driving performance, compared to those of partial sleep deprivation and placebo Abstract Introduction Methods Results Discussion Chapter 5 Residual effects of evening and middle-of-the-night administration of zaleplon and 20 mg on memory and actual driving performance Abstract Introduction Methods Results Discussion Chapter 6 Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcohol Abstract Introduction Methods Results Discussion Chapter 7 Residual effects on actual car driving of evening dosing of chlorpheniramine 8 and 12 mg when used with terfenadine 60 mgin the morning Abstract Introduction Methods Results Discussion Chapter 8 Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance Abstract Introduction Materials and methods Results Discussion Chapter 9 Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females Abstract Introduction Materials and methods Results Discussion