Hypo vs. hyperthyroid eye disease: Is there any difference?

Abstract

Background Thyroid-eye disease (TED) is the most common extra-thyroidal presentation of graves’ disease. We performed this study to compare clinical characteristics of TED in hypothyroid vs. hyperthyroid patients. Methods This was a retrospective analytical cross-sectional study in which we compared demographics, severity (EUGOGO classification) and activity (clinical activity score) of TED, thyroid disease duration, TED duration and clinical signs between hypothyroid eye disease (Ho-TED) and hyperthyroid eye disease (Hr-TED). Results Three hundred and seventy-four patients (341 Hr-TED and 33 Ho-TED) with a female to male ratio of 1.4:1 were identified in our study. Female to male ratio was 1.3:1 in hyperthyroid and 4.5:1 in hypothyroid group (P=0.005). The duration of thyroid disease was longer in Ho-TED (P=0.002) while the duration of eye disease was longer in Hr-TED (P=0.92). Most of the patients in hyperthyroid (153,48.1%) and hypothyroid group (24, 80.0%) developed eye involvement after thyroid disease (P=0.003). Severity (P=0.13) and activity (P=0.11) was not different between Hr-TED and Ho-TED patients (Table 1). Conclusion The result of our study showed several differences between the Hr/Ho TED patients included sex, duration of thyroid disease and pattern of eye involving.