Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia

Suwaki, Naoko; Masuyama, Hisashi; Nakatsukasa, Harushige; Masumoto, Akio; Sumida, Yoshio; Takamoto, Norio; Hiramatrsu, Yuji

doi:10.1016/j.ajog.2006.04.003

Cited by 69 publications

(55 citation statements)

References 31 publications

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“…Decreased adiponectin concentrations in our study are consistent with some earlier reports, 25,26 whereas other investigators 27,28 have found high adiponectin concentrations in preeclamptic women. Ramsay et al 29 speculated that the elevation of adiponectin in preeclamptic women may be secondary to exaggerated non-specific adipocyte lipolysis or as a physiological response to enhance fat utilization.…”

Section: Adipocytokines and Preeclampsia T Mori Et Alsupporting

confidence: 83%

Adipocytokines and endothelial function in preeclamptic women

et al. 2010

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Visceral fat accumulation stimulates the production of adipocytokines in patients with metabolic syndrome. Excess body weight gain during pregnancy is a risk factor for preeclampsia. To evaluate whether the pathogenesis of preeclampsia is similar to that of metabolic syndrome, we measured plasma adipocytokine concentrations and investigated the association between plasma adiponectin concentrations and body weight gain or endothelial function in preeclamptic women. We investigated 15 preeclamptic and 17 women with uncomplicated pregnancies. Women with preeclampsia had significantly lower plasma concentrations of adiponectin (10.2 ± 2.0 vs. 7.3 ± 2.2 lg ml À1 , Po0.01), but higher concentrations of leptin, plasminogen activator inhibitor-1, interleukin-6, vascular cell adhesion molecule-1, E-selectin and C-reactive protein. Plasma triglyceride levels were significantly higher in preeclamptic patients, but the levels of other lipids did not differ significantly between the two groups. We found that flow-mediated vasodilation was significantly decreased in preeclamptic women compared with controls (10.6 ± 6.4 vs. 3.8 ± 2.0%, Po0.001). Plasma adiponectin concentrations correlated negatively with body mass index (r¼À0.50, Po0.05) and body weight gain during pregnancy (r¼À0.63, Po0.01), and positively with flow-mediated vasodilation (r¼0.50, Po0.05) in preeclamptic women, but not in women with uncomplicated pregnancies. Similar to the patients with metabolic syndrome, we found that dysregulation of adipocytokines, such as low adiponectin levels and high levels of other adipocytokines, and excess body weight gain during pregnancy, may decrease plasma adiponectin concentrations that are associated with endothelial dysfunction in preeclamptic women.

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Section: Adipocytokines and Preeclampsia T Mori Et Alsupporting

confidence: 83%

Adipocytokines and endothelial function in preeclamptic women

et al. 2010

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“…61 The few studies showing that circulating profiles of adiponectin vary through human gestation are contradictory. Fuglsang et al 62 demonstrated variation, with peak values at mid-pregnancy, whereas Suwaki et al 63 reported no differences during human gestation. Studies on rats support the latter view of no specific pattern in circulating adiponectin during pregnancy.…”

Section: Effects Of Adiponectin On Reproduction and Fertilitymentioning

confidence: 98%

“…65 This pattern is reversed in late pregnancy, as pre-eclampsia is associated with hyperadiponectinemia. 66 Other studies report that hypoadiponectinemia and preeclampsia correlate only when obesity 63 and gestational diabetes 67 are present as complicating factors.…”

Section: Effects Of Adiponectin On Reproduction and Fertilitymentioning

confidence: 99%

The ‘beneficial’ adipokines in reproduction and fertility

et al. 2007

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The objective of this study was to review the available information on the signaling proteins produced by adipose tissue in the context of their role in regulating reproductive processes, including ovarian and uterine function. It is well known that both obesity and excessive leanness are associated with reproductive dysfunction. Adipokines are cytokines predominately or exclusively expressed by adipose tissue that circulate and affect target tissues. Four known adipokines, adiponectin, visfatin/ PBEF, omentin and vaspin, all increase tissue sensitivity to insulin, and are thus described as 'beneficial'. There is strong support for a role for adiponectin in the function of the ovary and placenta. There is evidence for direct effects of this adipokine on the late stages of folliculogenesis, and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles. In addition, clinical and genomic studies associate hypoadiponectinemia with obesity-related reproductive disorders, including the polycystic ovarian syndrome. The roles for visfatin/PBEF, omentin and vaspin in reproduction remain to be established. The conclusion thus drawn is that the expression of insulin-sensitizing adipokines varies with adipose abundance. These adipokines have demonstrated both the potential effects on ovarian function and the possible effects on the formation of the placenta, acting through multiple mechanisms.

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“…35 Expansion of the vascular bed in adipose tissue in obese women may contribute to an imbalance of angiogenesis-related factors. Suwaki et al 36 reported that among 27 women with pre-eclampsia, sFlt-1 levels were significantly lower in the overweight group compared with the normal weight group. However, in contrast to the results of our study, there was no significant difference in the levels of sFlt-1 in obese and non-obese subjects in their normotensive control group.…”

Section: Discussionmentioning

confidence: 99%

The Interrelationship of Complement-Activation Fragments and Angiogenesis-related Factors in Early Pregnancy and Their Association With Preeclampsia

Lynch

Murphy

Gibbs

et al. 2011

Obstetric Anesthesia Digest

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Objective-To determine the interrelationships during early pregnancy of complement-activation fragments Bb, C3a and sC5b-9, and angiogenesis-related factors placental growth factor (PiGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and their associations with pre-eclampsia. Design-Prospective cohort study. Setting-Denver complement study (June 2005-June 2008).Population-A total of 668 pregnant women with singleton gestations, recruited between 10 and 15 weeks of gestation.Methods-Using univariable and multivariable logistic regression analysis, concentrations of complement-activation fragments and angiogenesis-related factors were compared between 10 and Correspondence: Dr A Lynch, Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Mail Stop B198, 12631 East 17th Avenue, Aurora, CO 80045, USA. anne.lynch@ucdenver.edu. Disclosure of interestsThe authors have nothing to disclose. Contribution to authorshipAML designed and oversaw the study, conducted the data analysis, obtained the funding and wrote the manuscript; JRM provided statistical consultation; PCG provided consultation on the interpretation of complement results; RJL contributed his expertise in the area of angiogenesis-related factors; RSG contributed his expertise in maternal-fetal medicine. VMH and JES contributed their expertise in the area of complement research, and VMH served as mentor to AML on her NICHD K23 grant. Details of ethics approvalThe Colorado Multiple Institutional Review Board approved the study (COMIRB protocol number 07-0960). Interrelationships between these variables were tested using the non-parametric Spearman rank correlation coefficient. HHS Public AccessMain outcome measure-Pre-eclampsia. The association of complement-activation fragments and angiogenesis-related factors with obesity was also examined.Results-The mean (±SD) levels of complement Bb in early pregnancy among women who did and did not develop pre-eclampsia were 0.84 (±0.26) µg/ml and 0.69 (±0.2) µg/ml, respectively (P = 0.001). Concentrations of PiGF were significantly (P = 0.01) lower (31 ± 12 pg/ml) in early pregnancy in the pre-eclamptic group of women, as compared with the normotensive group (39 ± 32 pg/ml). The adjusted odds ratio (AOR) of Bb and PiGF were 2.1 (CI = 1.4-3.1, P < 0.0003) and 0.2 (CI = 0.07-0.7, P = 0.01), respectively. There was no significant difference in the levels of C3a, sC5b-9, sFlt-1 and sEng in early pregnancy among women who developed pre-eclampsia, compared with women who remained normotensive during pregnancy. Higher levels of Bb (P = 0.0001) and C3a (P = 0.03), and lower levels of sFlt-1 (P = 0.0002) and sEng (P = 0.0001) were found among women with obesity, compared with non-obese controls. No meaningful relationships were found between the complement-activation fragments and the angiogenesisrelated factors.Conclusions-In this cohort during early pregnancy, increased concentrations of complementactivation factor Bb and lower concentrations of PiGF were ...

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Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia

Cited by 69 publications

References 31 publications

Adipocytokines and endothelial function in preeclamptic women

Adipocytokines and endothelial function in preeclamptic women

The ‘beneficial’ adipokines in reproduction and fertility

The Interrelationship of Complement-Activation Fragments and Angiogenesis-related Factors in Early Pregnancy and Their Association With Preeclampsia

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