Hypocalcemia in the Critically Ill: A Mini-Review

Naafs, Michael Ab

doi:10.15406/emij.2017.05.00130

Cited by 2 publications

(1 citation statement)

References 51 publications

(72 reference statements)

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“…Also, some studies used corrected calcium values while others measured ionized calcium. It is also not clear if the calcium measurements were made for diagnostic, screening, homeostatic or daily routine purposes (9) .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Hypocalcemic Patients at Surgical Intensive Care Unit of Zagazig University Hospitals

hossary¹,

Eldin²,

Matar³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Hypocalcemic Patients at Surgical Intensive Care Unit of Zagazig University Hospitals

hossary¹,

Eldin²,

Matar³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Decreased level of serum NT-proCNP associates with disease severity in COVID-19

et al. 2023

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Background C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome. Methods In this retrospective analysis, we determined the serum level of NT-proCNP in hospitalized patients with symptoms of upper respiratory tract infection, using their blood samples taken on admission, stored in a biobank. The NT-proCNP levels of 32 SARS-CoV-2 positive and 35 SARS-CoV-2 negative patients were measured to investigate possible correlation with disease outcome. SARS-CoV-2 positive patients were then divided into two groups based on their need for intensive care unit treatment (severe and mild COVID-19). Results The NT-proCNP was significantly different in the study groups (e.g. severe and mild COVID-19 and non-COVID-19 patients), but showed inverse changes compared to previous observations in septic patients: lowest levels were detected in critically ill COVID-19 patients, while highest levels in the non-COVID-19 group. A low level of NT-proCNP on admission was significantly associated with severe disease outcome. Conclusions Low-level NT-proCNP on hospital admission is associated with a severe COVID-19 disease course. The pathomechanism underlying this observation remains to be elucidated, while future studies in larger patient cohorts are necessary to confirm these observations and reveal therapeutic importance. Trial registration DRKS00026655 Registered 26. November 2021

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Hypocalcemia in the Critically Ill: A Mini-Review

Cited by 2 publications

References 51 publications

Risk Factors of Hypocalcemic Patients at Surgical Intensive Care Unit of Zagazig University Hospitals

Risk Factors of Hypocalcemic Patients at Surgical Intensive Care Unit of Zagazig University Hospitals

Decreased level of serum NT-proCNP associates with disease severity in COVID-19

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