Hypocalcemic cardiac failure in the Emergency Department

Hurley, Katrina; Baggs, Doug

doi:10.1016/j.jemermed.2004.06.014

Cited by 68 publications

(42 citation statements)

References 28 publications

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“…Second, hypocalcemia could reduce renal sodium excretion, thus contributing to fluid overload 19 and diminished myocardial contractility, as demonstrated by decreased left ventricular work index. 20,21 To our knowledge, this is the first study to evaluate the association between serum calcium and the GRACE risk score. The current GRACE risk score only includes 2 laboratory-based biomarkers: SCr and troponin.…”

Section: Discussionmentioning

confidence: 99%

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Yan

Liu

Peng

et al. 2016

Clinical Cardiology

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Background: The Global Registry of Acute Coronary Events (GRACE) risk score has been extensively validated to predict risk during hospitalization in patients with acute coronary syndrome (ACS). Recently, serum calcium has been suggested as an independent predictor for in-hospital mortality in patients with ST-segment elevation myocardial infarction; however, the relationship between the 2 has not been evaluated. Hypothesis: The combination of GRACE risk score and serum calcium could provide better performance in risk prediction. Methods: The study enrolled 2229 consecutive patients with ACS. Independent predictors were identified by a multivariate logistic regression model. The incremental prognostic value added by serum calcium to the GRACE score was evaluated by receiver operating characteristic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Area under the curve increased significantly after adding serum calcium to the GRACE score (0.685 vs 0.746; Z = 2.617, P = 0.009). Furthermore, inclusion of serum calcium in the GRACE score enhanced NRI (0.524; P = 0.009) and IDI (0.011; P = 0.003). Conclusions: Lower serum calcium level on admission is a possible indicator of increased risk of in-hospital mortality in ACS patients. Inclusion of serum calcium in the GRACE score may lead to a more accurate prediction of this risk. Large prospective studies are needed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Yan

Liu

Peng

et al. 2016

Clinical Cardiology

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“…Twelve studies were conducted in the USA, two in the UK, one in Ireland, one in Canada, one in Australia, one in Italy and one in Germany. Response rates ranged between 49% 102 and 100%, 103 and the number of participants was between 95 104 and 3455, 105 with a total of 11,849 across all the studies. Twelve studies were conducted in a range of hospital settings, including one in a maternity unit and one in an…”

Section: Quantitative Studiesmentioning

confidence: 99%

“…The participants in a study by Hurley and colleagues 103 were 304 non-critically ill women, aged 16-95 years, who presented to emergency departments at two Canadian health centres. Eighty-six percent supported universal screening of women patients for partner violence, with no age differences.…”

Section: Friedman and Colleaguesmentioning

confidence: 99%

How far does screening women for domestic (partner) violence in different health-care settings meet the UK National Screening Committee criteria for a screening programme? Systematic reviews of nine UK National Screening Committee criteria

Feder

Ramsay²,

Dunne³

et al. 2009

Health Technol Assess

291

269

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“…Intracellular calcium in the sarcoplasmic reticulum initiates myocardial contraction when it binds to the troponin-tropomyosin complex, permitting cross-linkage between actin and myosin [5]. The strength of the contraction is influenced by the magnitude of extracellular calcium influx.…”

Section: Discussionmentioning

confidence: 99%

“…Total plasma calcium levels at the onset of hypocalcemic heart failure are extremely low, with a range of 4-6 mg/dL after correction for plasma albumin. After aggressive calcium supplementation, hypocalcemic heart failure can be recovered completely within a few weeks to a few months [5,7].…”

Section: Discussionmentioning

confidence: 99%

Reversible Heart Failure and Rhabdomyolysis Caused by Primary Hypoparathyroidism during Lactation

et al. 2011

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Hypocalcemia can be complicated, on rare occasions, by congestive heart failure and may also be associated with labor and lactation in some cases. Herein, we report a 30-year-old woman with hypocalcemia-induced heart failure secondary to primary idiopathic hypoparathyroidism precipitated by lactation. The patient presented with chest pain and paresthesia in both arms and legs during breast-feeding after her second delivery. She had severe hypocalcemia and low parathyroid hormone levels. Hypocalcemiainduced rhabdomyolysis further aggravated her hypocalcemia symptoms. The echocardiogram showed global hypokinesia with an ejection fraction of 47%. After calcium and vitamin D replacement, her symptoms and ventricular function improved. Hypocalcemia needs to be considered in patients with heart failure, because it is readily reversible. To the best of our knowledge, this is the first report of a patient with heart failure and rhabdomyolysis induced by primary hypoparathyroidism during lactation. (Endocrinol Metab 26:268-271, 2011)

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Hypocalcemic cardiac failure in the Emergency Department

Cited by 68 publications

References 28 publications

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

How far does screening women for domestic (partner) violence in different health-care settings meet the UK National Screening Committee criteria for a screening programme? Systematic reviews of nine UK National Screening Committee criteria

Reversible Heart Failure and Rhabdomyolysis Caused by Primary Hypoparathyroidism during Lactation

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