Hypocholesterolemia during mixed manic episodes

Cassidy, Frederick; Carroll, Bernard J.

doi:10.1007/s00406-002-0367-4

Cited by 24 publications

(22 citation statements)

References 45 publications

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“…This finding agrees with aberration of cholesterol in a single manic (Pae et al, 2004), mixed (Cassidy and Carroll, 2002), or pure manic (Ghaemi et al, 2000;Cassidy and Carroll, 2002;Atmaca et al, 2002) episode.…”

Section: Discussionsupporting

confidence: 86%

“…A few studies investigated serotonin (5-hydroxytryptamine, 5-HT) levels (Takahashi, 1976;Saxena et al, 1999), monoamine oxidase (MAO) activity (Takahashi, 1977) and 5-HT2A receptors (Pandey et al, 2003) in manic patients using blood platelets as a peripheral model for the central serotonergic neurons (Plain and Berk, 2001). Manic patients had lower cholesterol levels than healthy controls (Ghaemi et al, 2000;Cassidy and Carroll, 2002;Atmaca et al, 2002), but no data are available either regarding the low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL) and triglycerides (TG) levels in mania, or platelet 5-HT, platelet MAO activity and lipid levels, especially in psychotic subtype of mania. The aim of the present study was to determine platelet 5-HT concentration, platelet MAO activity, serum cholesterol, LDL, HDL, TG and their relationship in male patients with psychotic and nonpsychotic bipolar I disorder -mania, and in healthy men.…”

Section: Introductionmentioning

confidence: 99%

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Platelet serotonin and serum lipids in psychotic mania

Šagud¹,

Mihaljević-Peleš²,

Pivac³

et al. 2007

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Platelet serotonin and serum lipids in psychotic mania

Šagud¹,

Mihaljević-Peleš²,

Pivac³

et al. 2007

Journal of Affective Disorders

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“…Manic and mixed episode subtypes were defined using a definition obtained from receiver operating characteristic analysis 22. That definition provides a more specific and less restrictive alternative to the current DSM-IV nomenclature for mixed mania and has been validated using epidemiologic variables21,23–25 and biomarkers 26,27…”

Section: Methodsmentioning

confidence: 99%

Insight in bipolar disorder: relationship to episode subtypes and symptom dimensions

Cassidy¹

2010

NDT

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BackgroundThe study of insight in bipolar disorder has received limited attention, despite its potential impact on treatment compliance and prognosis. In the current study we compare insight levels during different phases of bipolar disorder, and consider its relationship to symptoms dimensions and epidemiologic variables.MethodsInsight ratings obtained from 156 bipolar subjects in any phase of bipolar disorder were compared. A regression analysis was also conducted to identify symptom dimensions predictive of insight levels.ResultsGreater impairments in insight were observed during pure manic episodes than during mixed or depressed episodes, or during euthymia. Depressive symptoms were associated with better insight. Improvements in insight with treatment were neither complete nor universal. Lack of insight was unrelated to age, years of illness, age of first psychiatric illness, or lifetime number of hospitalizations.ConclusionsAlthough psychosis may be associated with impaired insight, other variables also impact on degree of impaired insight. Specifically, depressed mood appears to be associated with preservation of insight. That relationship may transcend strict syndromal diagnosis.

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“…Patients with manic or mixed syndromes have also had lower cholesterol concentrations than controls in a number of studies (Swartz, 1990; Ghaemi et al, 2000; Atmaca et al, 2002; Cassidy and Carroll, 2002; Pae et al, 2004; Sagud et al, 2007). In one report, patients with bipolar disorder in remission likewise had lower cholesterol concentrations than controls (Atmaca et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Cholesterol and affective morbidity

Fiedorowicz

Palagummi

Behrendtsen

et al. 2010

Psychiatry Research

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Depression and mania have been linked with low cholesterol though there has been limited prospective study of cholesterol and subsequent course of affective illness. We studied the relationship between fasting total cholesterol and subsequent depressive and manic symptoms. A total of 131 participants from a prospective cohort study were identified as having had a fasting total cholesterol evaluation at intake. Participants were predominantly inpatients at index visit and were followed for a median of 20 and up to 25 years. Cholesterol was modeled with age, gender, and index use of a mood stabilizer in linear regression to assess its influence on subsequent depressive symptom burden in participants with unipolar disorder as well as depressive and manic symptom burden in participants with bipolar disorder. Among bipolar participants (N=65), low cholesterol predicted a higher proportion of follow-up weeks with manic, but not depressive symptoms. Cholesterol did not appear to predict depressive symptom burden among participants with unipolar depression (N=66). Lower cholesterol levels may predispose individuals with bipolar disorder to a greater burden of manic symptomatology and may provide some insight into the underlying neurobiology.

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Hypocholesterolemia during mixed manic episodes

Abstract: Fasting serum cholesterol levels are low in manic patients, especially during mixed bipolar episodes. Cholesterol, which has been reported to be a negative acute phase reactant, may be lower during mixed states as a result of an immune activation.

Cited by 24 publications

References 45 publications

Platelet serotonin and serum lipids in psychotic mania

Platelet serotonin and serum lipids in psychotic mania

Insight in bipolar disorder: relationship to episode subtypes and symptom dimensions

Cholesterol and affective morbidity

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