Hypodontia as a risk marker for epithelial ovarian cancer

Chalothorn, Leigh A.; Beeman, Cynthia S.; Ebersole, Jeffrey L.; Kluemper, G. Thomas; Hicks, E. Preston; Kryscio, Richard J.; DeSimone, Christopher P.; Modesitt, Susan C.

doi:10.14219/jada.archive.2008.0132

Cited by 49 publications

(60 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies reported a higher presence of cancer in people with hypodontia (16,17,18). Fekonja et al (19) stated that the results of their study statistically support a possible association between EOC (epithelial ovarian cancer) and hypodontia.…”

Section: Materijali I Metodementioning

confidence: 94%

“…Neki istraži-vači smatrali su da se tijekom godina povećala prevalencija hipodoncije (2), a drugi stručnjaci pak ne podupiru to stajalište (14,15). U nekoliko istraživanja istaknuta je veća pojavnost raka kod ljudi s hipodocijom (16,17,18). Tako Fekonja i suradnici (19) tvrde da rezultati njihova istraživanja statistički podupiru moguću povezanost epitelnoga ovarijalnog karcinoma i hipodoncije.…”

Section: Uvodunclassified

See 1 more Smart Citation

Prevalence and Pattern of Non-Syndromic Hypodontia in a Group of Turkish Children

Gökkaya¹,

Kargül²

2016

Acta Stomatol Croat

View full text Add to dashboard Cite

Section: Materijali I Metodementioning

confidence: 94%

Section: Uvodunclassified

Prevalence and Pattern of Non-Syndromic Hypodontia in a Group of Turkish Children

Gökkaya¹,

Kargül²

2016

Acta Stomatol Croat

View full text Add to dashboard Cite

“…It is intriguing to consider a more general connection between tooth agenesis and cancer predisposition and that tooth agenesis could in some cases be an indication of the latter. Interestingly, an increased prevalence of tooth agenesis was recently reported among patients of ovarian epithelial carcinoma (Chalothorn et al, 2008). Major hereditary contribution to cancer may be given by largely unknown alleles of low penetrance (Amundadottir et al, 2004;de la Chapelle, 2004), and some of these alleles may also contribute to the background of tooth agenesis.…”

Section: Axin2 and Paradoxes Of Wnt Signalingmentioning

confidence: 99%

Genetic basis of tooth agenesis

Nieminen¹

2009

J Exp Zool Pt B

230

215

View full text Add to dashboard Cite

Tooth agenesis or hypodontia, failure to develop all normally developing teeth, is one of the most common developmental anomalies in man. Common forms, including third molar agenesis and hypodontia of one or more of the incisors and premolars, constitute the great majority of cases. They typically affect those teeth that develop latest in each tooth class and these teeth are also most commonly affected in more severe and rare types of tooth agenesis. Specific vulnerability of the last developing teeth suggests that agenesis reflects quantitative defects during dental development. So far molecular genetics has revealed the genetic background of only rare forms of tooth agenesis. Mutations in MSX1, PAX9, AXIN2 and EDA have been identified in familial severe agenesis (oligodontia) and mutations in many other genes have been identified in syndromes in which tooth agenesis is a regular feature. Heterozygous loss of function mutations in many genes reduce the gene dose, whereas e.g. in hypohidrotic ectodermal dysplasia (EDA) the complete inactivation of the partially redundant signaling pathway reduces the signaling centers. Although these mechanisms involve quantitative disturbances, the phenotypes associated with mutations in different genes indicate that in addition to an overall reduction of odontogenic potential, tooth class-specific and more complex mechanisms are also involved. Although several of the genes so far identified in rare forms of tooth agenesis are being studied as candidate genes of common third molar agenesis and incisor and premolar hypodontia, it is plausible that novel genes that contribute to these phenotypes will also become identified.

show abstract

“…The performed search in PubMed and Scopus revealed a total of 43 and 39 search results, respectively, among which 4 studies (4 case series) were identified as eligible for inclusion in this review, according to the inclusion criteria (8)(9)(10)(11). No additional studies were identified by searching the references of the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…It is thought to be a multifactorial condition related both to genes as well as environmental effect. In recent studies, it was shown that genes related to hypodontia could also be related to ovarian cancer as women with hypodontia have 8 times higher risk of ovarian cancer (11). Some of the genes that are related to hypodontia are paired box 9 (PAX9), MSX1, and axis inhibition protein 2 (AXIN2) (14, 15).…”

Section: Discussionmentioning

confidence: 99%

Hypodontia and ovarian cancer: A systematic review

Iavazzo

Papakiritsis²,

Gkegkes

2016

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Spanish were excluded from this review. The retrieved data from each of the included studies were focused on the publication type, the number of patients included in each study, the number of patients included in the control group, the incidence of hypodontia, the number of missing teeth, the type of missing teeth, the distribution of hypodontia, the presence of ovarian cancer in family medical history, and the presence of isolated genes correlated to ovarian cancer. ResultsThe performed search in PubMed and Scopus revealed a total of 43 and 39 search results, respectively, among which 4 studies (4 case series) were identified as eligible for inclusion in this review, according to the inclusion criteria (8)(9)(10)(11). No additional studies were identified by searching the references of the included studies. The selected studies for inclusion are presented in detail in Figure 1 (flow diagram). The principal characteristics of the included studies in our review (publication type, number of patients, control group, incidence of hypodontia, number of missing teeth, type of missHypodontia can be defined as the non-formation of one or more teeth during the developmental period. Mutation in several genes related to tooth formation has previously been correlated with cancer. Regarding the ovarian cancer, there are few studies that associate the presence of hypodontia with ovarian cancer. A systematic literature search was performed in PubMed and Scopus. In total, 385 patients were included in this study. Control group was present in 3 out of 4 studies (340 patients). Hypodontia was present in 56 out of 290 patients (incidence of 19.3%). Only in 2 out of 4 studies, the number of missing teeth was mentioned (47 teeth), while the majority of them were either maxillary second premolars or maxillary lateral incisors. Unilateral distribution of the missing teeth was present in 28 out of 46 patients, while bilateral distribution of the missing teeth was present in 18 out of 46 patients. The presence of ovarian cancer in the family medical history occurred in 12 out of 33 patients. Only 1 out of 4 studies examined the presence of genes with mutations in the included patients. Based on our findings, the lack of clinical studies was the principal obstacle to clarify the possible predictive value of hypodontia in the early prediction of patients with higher risk of ovarian cancer. (J Turk Ger Gynecol Assoc 2016; 17: 41-4) Keywords: Hypodontia Abstract ing teeth, distribution of hypodontia, presence of ovarian cancer in family medical history, and isolated genes) are presented in Table 1. In total, 385 patients were included in this study. Control group was present in 3 out of 4 studies (340 patients). Hypodontia was present in 56 out of 290 patients (19.3%). Only in 2 out of 4 studies, the number of missing teeth was mentioned (47 teeth), and the majority of them were either maxillary second premolars or maxillary lateral incisors. Unilateral distribution of the missing teeth was present in 28 out of 46 patients, while bilater...

show abstract

Hypodontia as a risk marker for epithelial ovarian cancer

Cited by 49 publications

References 31 publications

Prevalence and Pattern of Non-Syndromic Hypodontia in a Group of Turkish Children

Prevalence and Pattern of Non-Syndromic Hypodontia in a Group of Turkish Children

Genetic basis of tooth agenesis

Hypodontia and ovarian cancer: A systematic review

Contact Info

Product

Resources

About