Hypoglycemic activity of<i>Erythrina variegata</i>leaf in streptozotocin-induced diabetic rats

Kumar, Arvind; Lingadurai, Sutharson; Shrivastava, Tarani Prakash; Bhattacharya, Sanjib; Haldar, Pallab Kanti

doi:10.3109/13880209.2010.529615

Cited by 28 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, Erythrina variegata [22], Erythrina crystagalli, Erythrina indica, Erythrina poeppigiana [22], and Erythrina arborescens ) and was identified as a DPP-IV inhibitor by our VS procedure. Extracts from Erythrina variegata , Erythrina senegalensis , Erythrina addisoniae , Erythrina abyssinica , and Erythrina mildbraedii are reported to enhance antidiabetic activity [23]–[27]. Isoprenylated flavonoids isolated from Erythrina mildbraedii and prenylflavonoids isolated from the Erythrina senegalensis roots have been described as inhibitors of two other proteins frequently targeted in T2DM treatment ( i.e.…”

Section: Resultsmentioning

confidence: 99%

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

et al. 2012

View full text Add to dashboard Cite

BackgroundNatural extracts play an important role in traditional medicines for the treatment of diabetes mellitus and are also an essential resource for new drug discovery. Dipeptidyl peptidase IV (DPP-IV) inhibitors are potential candidates for the treatment of type 2 diabetes mellitus, and the effectiveness of certain antidiabetic extracts of natural origin could be, at least partially, explained by the inhibition of DPP-IV.Methodology/Principal FindingsUsing an initial set of 29,779 natural products that are annotated with their natural source and an experimentally validated virtual screening procedure previously developed in our lab (Guasch et al.; 2012) [1], we have predicted 12 potential DPP-IV inhibitors from 12 different plant extracts that are known to have antidiabetic activity. Seven of these molecules are identical or similar to molecules with described antidiabetic activity (although their role as DPP-IV inhibitors has not been suggested as an explanation for their bioactivity). Therefore, it is plausible that these 12 molecules could be responsible, at least in part, for the antidiabetic activity of these extracts through their inhibitory effect on DPP-IV. In addition, we also identified as potential DPP-IV inhibitors 6 molecules from 6 different plants with no described antidiabetic activity but that share the same genus as plants with known antidiabetic properties. Moreover, none of the 18 molecules that we predicted as DPP-IV inhibitors exhibits chemical similarity with a group of 2,342 known DPP-IV inhibitors.Conclusions/SignificanceOur study identified 18 potential DPP-IV inhibitors in 18 different plant extracts (12 of these plants have known antidiabetic properties, whereas, for the remaining 6, antidiabetic activity has been reported for other plant species from the same genus). Moreover, none of the 18 molecules exhibits chemical similarity with a large group of known DPP-IV inhibitors.

show abstract

Section: Resultsmentioning

confidence: 99%

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The freeze-dried stem bark extracts of Erythrina abyssinica displayed potent dose-dependent antihyperglycemic effects in rats chronically fed a high-fat/high-sugar diet. Previous studies have shown that plant species belonging to this genus including the species that is the subject of this study possess antihyperglycemic activity [37,38]. The freeze-dried extracts of Erythrina abyssinica also possessed significant effects on insulin sensitivity.…”

Section: Discussionmentioning

confidence: 79%

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Yenesew

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver disease (NFLD) is the hepatic manifestation of the metabolic syndrome recognized as the most prevalent chronic liver disease across all age groups. NFLD is strongly associated with obesity, insulin resistance, hypertension and dyslipidemia. Extensive research efforts are geared, through pharmacological approach, towards preventing or reversing this. Erythrina abyssinica Lam ex DC is an indigenous tree used widely used in traditional medicine, including for the treatment of liver related diseases, and has been shown to possess hypoglycemic, anti-oxidant, antimicrobial and anti-plasmodia effects. The present study is aimed at establishing the effects of E. abyssinica on the development of Non-alcoholic fatty liver disease induced by a high-fat and high-sugar diet in rats, in-vivo model. (40) were randomly divided into five groups: positive control (pioglitazone), Negative control (high fat/high sugar diet), low test dose (200 mg/kg), high test dose (400 mg/kg) and normal group (standard chow pellets and fresh water). Methods: Forty ratsThe inhibitory effect of the stem bark extract of E. abyssinica on the development of NAFLD was evaluated by chronic administration the herb extracts to rats on a high-fat/high-sugar diet.Biochemical indices of hepatic function including serum lipid profile, serum aspartate transaminase and alanine transaminase levels were then determined. Histological analysis of liver samples was carried out to quantify the degree of steato-hepatitis. Liver weights were taken and used to determine the hepatic index. The data was analyzed using one-way ANOVA, and Tukey's post-hoc tests were done in cases of significance. Histology data was analyzed using Kruskal-Wallis and Dunn's post-hoc test was done in cases of significance. Significance was set at p<0.05. Results:The freeze dried extract of E. abyssinica had significant effects on fasting blood glucose [5.43 ± 0.17 (HF/HSD) vs 3.8 ± 0.15 (E 400 mg/kg) vs 4.54 ± 0.09 (E 200 mg/kg) vs. 4.16 ± 0.13 (PIOG) vs. 2.91 ± 0.16 (normal control): P value < 0.0001], and insulin sensitivity [329.4 ± 13.48 mmol/L · min (HF/HSD) vs. 189.8 ± 12.11 mmol/L · min (E 400 mg/kg) vs. 233.8 ± 6.55 mmol/L · min (E 200 mg/kg) vs. 211.1 ± 7.35 mmol/L · min (PIOG) vs. 142.9 ± 11.94 mmol/L · min: P value < 0.0001],The extract had significant effects on hepatic indices including, hepatic triglycerides (P value < 0.0001), liver weights (P value < 0.0001), liver weight-body weight ratio (P value < 0.0001), serum ALT levels (P value < 0.0001), serum AST (P value < 0.0017), serum total cholesterol (P value < 0.0001), serum triglycerides (P value < 0.0001), and serum LDL-cholesterol (P value < 0.0001). The extracts however showed no significant effects on HDL-cholesterol (P value = 0.4759).Histological analysis showed that the extract appears to possess protective effects against steatosis, inflammation and hepatic ballooning, with the high dose (400mg/kg) being more hepatoprotective. Conclusion:The freeze dried stem bark extract of Eryth...

show abstract

“…Several species have been used in the indigenous medicine as eyewashes or wounds, for pain relief of arthritis or as calm and relaxants agents (Garin-Aguilar, et al, 2000). Interesting also has been described the hypoglycemic activity of E. variegata leaf in streptozotocininduced diabetic rats (Kumar, et al, 2011) and the authors conclude that leaf of this plant has promising hypoglycemic action in STZ-induced diabetic rats substantiating in this way the ethnomedical use. The study of the antidiarrhoeal effects of ethanolic leaf extract of E. indica L. in experimental animals done by Sonia and coworkers (Sonia, et al, 2011) showed that this extract elicit potential antidiarrhoeal effects and thus substantiated its traditional claim as an antidiarrohoeal agent, also their findings suggest that the main constituents of the extracts were alkaloids Also they have been related with antiasthmatic, diuretic or hypnotics properties.…”

Section: Pharmacologymentioning

confidence: 92%

Erythrina, a Potential Source of Chemicals from the Neotropics

Soto-Hernández¹,

García-Mateos²,

Miguel-Chávez³

et al. 2012

Bioactive Compounds in Phytomedicine

View full text Add to dashboard Cite

Hypoglycemic activity ofErythrina variegataleaf in streptozotocin-induced diabetic rats

Cited by 28 publications

References 14 publications

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Erythrina, a Potential Source of Chemicals from the Neotropics

Contact Info

Product

Resources

About