Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Abstract

Objective: To evaluate and compare the hypoglycemic activity of 10 medicinal plants extract that is used empirically to treat hyperglycemia in Indonesia, to determine plant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose-induced mice with glucose tolerance test. The ethanolic extracts of Mangifera indica L. leaves, Persea americana Mill. leaves, Acorus calamus L. rhizome, Phyllanthus niruri L. herb, Syzygium cumini (L.) skeels bark, Zingiber officinale Roscoe rhizome, Moringa oleifera Lam. leaves, Tamarindus indica L. seed, Momordica charantia L. fruits, and Azadirachta indica A. juss leaves, which were given orally at the same dose of 300 mg/kg bw. The blood samples were used for determination of glucose level examination using a glucose meter and test strips (Accu-Chek). Results:The ethanolic extract of M. indica L. leaves has the best activity in reduction of blood glucose level in mice, followed by Z. officinale Roscoe rhizome, A. calamus L. rhizome, T. indica L. seed., M. charantia L. fruit., S. cumini (L.) skeels bark, P. niruri L. herb., P. americana Mill. leaves, and A. indica A. juss leaves. Conclusion:Results of this study suggest the potential use of M. indica L. leaves extract in the therapy of hyperglycemia.

Blood Glucose Levels and the Microscopic Structure of Kidney Wistar Rat Diabetes Mellitus Under the Effect of Lawsonia Inermis (Linn.) Leaves Ethanolic Extract

“…The traditional medicine from the plant that is less toxic and less severe side effect than chemical medicine. Since over the years, traditional medicine and traditional medical treatment have been existing in Indonesia [2]. One of the plants in Indonesia that is often used as a medicine is Henna/Lawsonia inermis (Linn.…”