Hypoglycemic and in vitro antioxidant activity of ethanolic extracts of Ficus racemosa Linn. fruits

Abstract

The present study was carried out to evaluate hypoglycemic and in vitro antioxidant activity of ethanolic extracts of Ficus racemosa Linn. Fruits (EEFR). Antidiabetic potential of the plant extracts was evaluated by oral administration at the doses of 100 and 200 mg/kg on alloxan induced Swiss albino mice and in vitro antioxidant potential was investigated by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and total antioxidant capacity. Glucose tolerance test reveals that the extract at the doses of 100 mg/kg and 200 mg/Kg, showed a significant decrease (p<0.05) of fasting blood glucose level after 3 hours of extract administration when compared to normal control. After prolonged study of 14 days, blood glucose level reduced at the significant level (p<0.05) as compared with alloxan induced diabetic control mice. At a dose of 100 mg/kg body weight, the extract significantly lowered blood glucose level and showed maximum reduction of 33.85% on day 14. The extract, at a dose of 200 mg/kg body weight produced maximum reduction of 41.91% on day 14 whereas inhibition of 45.49% was found for metformin on day 14. In antioxidant study, the extract showed significant activities in both of the antioxidant assays as compared to ascorbic acid in a dose dependent manner. In DPPH scavenging assay, the IC 50 value of the extract was found to be 140.55 µg/ml while the IC 50 value of ascorbic acid was 58.92 µg/ml. This study suggests that EEFR has both hypoglycaemic and antioxidant potential.

Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review

“…Examples of such studies are: Akter, Mahabub-Uz-Zaman, and Rahman, 2013; Al-Amin, Uddin, Rizwan, and Islam, 2013; Ali et al, 1993; Amran, Sultan, Rahman, and Rashid, 2013; Bhuyan, Rokeya, Masum, Hossain, and Mahmud, 2010; Borhanuddin, Shamsuzzoha, and Hussain, 1994b; A. Chowdhury and Biswas, 2012; A. R. Das, Mostofa, Hoque, Das, and Sarkar, 2010; Habib and Gafur, 2003; J. M. A. Hannan et al, 2003; E. Haque, Saha, Islam, and Islam, 2012; M. A. Hossain et al, 2012; Md Alamgir Hossain, Roy, Ahmed, Chowdhury, and Rashid, 2007b; M. Z. Hossain, Shibib, and Rahman, 1992; Islam et al, 2009; M. A. Islam et al, 2011; I. A. Jahan et al, 2009; Mostofa et al, 2007b; Mowl, Alauddin, Rahman, and Ahmed, 2009; Rafiq, Sherajee, Nishiyama, Sufiun, and Mostofa, 2009; Md Masudur Rahman, Hossain, Siddique, Biplab, and Uddin, 2012b; Md Mahfuzur Rahman, Sayeed, Haque, Hassan, and Islam, 2012; M. W. Rahman et al, 2005; Rokeya, Bhowmik, Khan, and Khter, 2009; M. G. Roy et al, 2010; Shahreen et al, 2012; Shibib, Khan, and Rahman, 1993; Sikder, Kaisar, Rahman, Hussain, and Rashid, 2011; Talukder, Khan, Uddin, Jahan, and Alam, 2012; Urmi et al, 2012; Zulfiker et al, 2011 [ 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 ]. These scientific studies emphasized the correlation among traditional use and the pharmacological properties of antidiabetic plants.…”

In vitro Antioxidant Activity and In vivo Anti-inflammatory Effect of Ricinus communis (L.) and Withania somnifera (L.) Hydroalcoholic Extracts in Rats

“…Superoxide anions are well known to damage biomolecules either directly or indirectly by producing -OH, H2O2, singlet oxygen, or peroxynitrite during aging and pathological conditions like ischemic reperfusion injury. It has also been observed that superoxides directly involve lipid peroxidation [36,37]. The antioxidant potential of RCE and WSE was assessed.…”

Biochemical and Histomorphometrical Analysis Of Hepatoprotective and Hypolipidemic Potential Of Combined Herbal Extract in Diabetic Rats

“…Among the herbs, Syzygium cumini seeds and Ficus racemosa fruits have many common antidiabetic phytochemicals. They are also renowned for their hepatoprotective and hypolipidemic role (Zulfiker et al, 2011;Behera et al, 2014). The previous researchers use either S. cumini seeds or F. racemosa fruits in individual dose.…”