Hypoglycemic, Antitussive and Analgesic Effects of Nanoparticles of Cordia myxa Fruits Extract

Abstract

Background: Cordia myxa is a plant from Boraginaceae family and has many useful therapeutic properties. Aim of the study is to compare the pharmacological efficacy of Cordia myxa hydro-alcoholic extract (Bulk Extract [BE]) and nanoparticles of hydro-alcoholic extract (NPE) including hypoglycemic, antitussive, anti-inflammatory and analgesic activity. Methods: Hydro-alcoholic maceration extract of dry fruits was powdered to nanoparticle size by ball-milling technique. Hyperglycemia and cough were induced in mice by alloxan (120 mg/kg, i.p.) and ammonia, respectively. Inflammatory and analgesic evaluations of extracts were carried out with the formalin-induced edema in the mice paw and acetic acid tests. NPE and BE were administrated at single dose (750 mg/kg, i.p.). Positive control group was received dextromethorphan (10 mg/kg, orally) in cough and indomethacin (25 mg/kg, orally) for analgesic models. Blood glucose level, the number of coughs and writhes and duration of foot lickings were calculated. Results: The blood glucose did not statistically reduce by extracts. Both extracts could significantly inhibit the frequency of cough and dramatically reduce the duration of paw licking. NPE could significantly reduce writhes. Conclusion: We concluded that extracts had no hypoglycemic activity. Both extracts created therapeutic activities better than dextromethorphan. NPE exerted better anti-inflammatory and analgesic activity compared to BE.

Search for the Natural Remedies for the Treatment of Dry Cough

“…However, both extracts were equally effective in reducing cough frequency (P=0.377). Notably, DXM only reduced the number of coughs to 20.17, which was also significant compared to the control group (P<0.0001) (Salimimoghadam et al 2019).…”

A review on traditional uses and applications of Cordia spp. (Boraginaceae) as a natural polymer in the development of food and pharmaceutical products

“…antidepressant activity in rats (Al-Awadi et al 2001, Schezaro-Ramos et al 2020, Zakerin et al 2021, as well as for their antitumor, analgesic, and antitussive activity in mice (Ibrahim et al 2019, Salimimoghadam et al 2019.…”

“…The resulting product was compared via in vitro test with a commercial formulation, revealing no significant difference in the percentage permeation of the drug. An antitussive effect has been observed in mice with synthetized with Cordia myxa L. extract at a concentration of 750 mg/Kg, resulting in a similar effect to the use of dextromethorphan with a dose of 10 mg/kg (Salimimoghadam et al 2019). The antioxidant and cytotoxic activities of micro and nanocapsules made with Cordia myxa L. extract have been evaluated because of its current and potential uses in the food industry (El-Massry et al 2021).…”

Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

“…The other herb is C. Myxa, which alleviates sore throat, cough and respiratory infections. According to the scientific researches, it has various therapeutic potentials such as anti-viral, anti-inflammatory, analgesic, and antitussive actions [25] , [26] , [27] .…”