Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients

Fuangchan, Anjana; Sonthisombat, Paveena; Seubnukarn, Tippawadee; Chanouan, Rapeepan; Chotchaisuwat, Pontap; Sirigulsatien, Viruch; Ingkaninan, Kornkanok; Plianbangchang, Pinyupa; Haines, Stuart T.

doi:10.1016/j.jep.2010.12.045

Cited by 156 publications

(96 citation statements)

References 31 publications

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“…However, as many studies report, there has been substantial emphasis on the anti-diabetic compounds and their hypoglycemic properties [30,31] . A number of reported clinical studies have shown that bitter melon extract from the fruit, seeds, and leaves contain several bioactive compounds that have hypoglycemic activity in both diabetic animals and humans [32,33] .…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…The possible modes of the hypoglycemic actions of M. charantia and its various extracts and compounds are its hypoglycemic effect [67,70] , stimulation of peripheral and skeletal muscle glucose utilisation [71,72] , inhibition of intestinal glucose uptake [73][74][75] , inhibition of adipocyte differentiation [76] , suppression of key gluconeogenic enzymes [77,78] , stimulation of key enzyme of HMP pathway [77] , and preservation of islet β cells and their functions [66] . Today, over 140 different studies worldwide have investigated anti-hyperglycemic and hypoglycemic effects of the different extracts and ingredients of M. charantia in both human and animal models [32,33,62] .…”

Section: Possible Modes Of Action Of M Charantia and Its Extractmentioning

confidence: 99%

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Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Joseph¹,

Jini²

2013

Asian Pacific Journal of Tropical Disease

388

252

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Section: Bioactive Compoundsmentioning

confidence: 99%

Section: Possible Modes Of Action Of M Charantia and Its Extractmentioning

confidence: 99%

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Joseph¹,

Jini²

2013

Asian Pacific Journal of Tropical Disease

388

252

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“…It was thus concluded that momordica charantia extract acted in synergism with oral hypoglycemics and potentiated their hypoglycemic effect in diabetic patients. The second trial was a multicenter, randomized, double-blind, active-control trial [67]. Type 2 diabetic subjects were randomly divided into four groups.…”

Section: Momordica Charantia (Bitter Melon)mentioning

confidence: 99%

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng¹

2012

FNA

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Hyperglycemia is a pathological condition associated with prediabetes and diabetes. The incidence of prediabetes and diabetes is increasing and imposes great burden on healthcare worldwide. Patients with prediabetes and diabetes have significantly increased risk for cardiovascular diseases and other complications. Currently, management of hyperglycemia includes pharmacological interventions, physical exercise, and change of life style and diet. Food supplements have increasingly become attractive alternatives to prevent or treat hyperglycemia, especially for subjects with mild hyperglycemia. This review summarized current patents and patent applications with relevant literature on five commonly used food supplements with claims of hypoglycemic effects, including emblica officinalis (gooseberry), fenugreek, green tea, momordica charantia (bitter melon) and cinnamon. The data from human clinical studies did not support a recommendation for all five supplements to manage hyperglycemia. Fenugreek and composite supplements containing emblica officinalis showed the most consistency in lowering fasting blood sugar (FBS) or glycated hemoglobin (HbA1c) levels in diabetic patients. The hypoglycemic effects of cinnamon and momordica charantia were demonstrated in most of the trials with some exceptions. However, green tea exhibited limited benefits in reducing FBS or HbA1c levels and should not be recommended for managing hyperglycemia. Certain limitations are noticed in a considerable number of clinical studies including small sample size, poor experimental design and considerable variations in participant population, preparation format, daily dose, and treatment duration. Future studies with more defined participants, standardized preparation and dose, and improved trial design and size are warranted.

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“…Glucokinase catalyzes the conversion of glucose to glucose -6-phosphate and play a central role in the maintenance of glucose homeostasis. In the liver this enzyme is an important regulator of glucose storage and disposes 18 .…”

Section: Evaluation Of Effect On Biochemical Variablesmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:Decalepis hamiltonii Wight and Arn. is an indigenous medicinal plant, which has a folk reputation in Western and southern India as hypoglycemic agent. The present investigation was carried out to evaluate the antidiabetic effect of ethanolic seed extract of Decalepis hamiltonii in alloxan induced diabetic Albino rats. Blood glucose levels and body weights of control and diabetic rats were monitored. In the present study activities of liver enzymes such as glucokinase, glucose -6-phosphatase and fructose -1-6-diphosphatase were also determined. Glibenclamide an antidiabetic oral drug was used as reference in the present investigation. Oral administration of ethanolic seed extract (20 mg/kg body weight) for 21 days resulted in a significant (P<0.05) decline in blood glucose from 264.03±10.07 to 90.16±2.82 mg/dl and significant recovery in body weight of diabetic rats. There was also a significant (P<0.05) reduction in the activities of glucose-6-phosphatase and fructose-1-6-disphosphatase , glutathione levels, lipid peroxidation as oxidative stress γ-Glutamyl transpeptidase, Glutathione S-transferase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), acid and alkaline phosphatases in liver were also evaluated. Further there was significant (P<0.05) increase in the activity of glucokinase in liver of diabetic rats when compared with that of diabetic control. Results indicate increased metabolization of glucose in treated rats. Increased levels of lipid peroxidation measured as 2-thiobarbituric acid reactive substances (TBARS) indicative of oxidative stress in diabetic rats were also normalized by treatment. The study clearly shows that the ethanolic seed extract of Decalepis hamiltonii possesses potent antidiabetic activity.

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Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients

Cited by 156 publications

References 31 publications

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

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