Hypoglyclemic Effects in Response to Abelmoshus Esculentus Treatment: A Research Framework using STZ-Induced Diabetic Rats

Amin, Indah Mohd

doi:10.7763/ijbbb.2011.v1.12

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…It also triggered the activation of kupffer cells that activated the immune boosting properties of the plant extracts when compared with the controls. This findings concurred with the work of Amin (2011) that evaluated the hypoglycemic effects in response to Abelmoschus esculentus treatment in STZ-induced diabetic rats. The cardiac cells treated with graded doses of the aqueous and methanol leaf extracts of A. caillei extracts of the rat heart showed bundles of myocardia fibers, with absent vasculopathy, asymmetric medial hypertrophy and the repaired blood vessel when compared with the untreated control.…”

Section: Discussionsupporting

confidence: 90%

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Enoyoze¹,

Idu²,

Gabriel³

2022

jcbr

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Diabetes mellitus is a lingering disease associated with pancreatic malfunctioning unable to synthesize sufficient insulin, or the insulin produced by the body cannot be effectively utilized, resulting in the accumulation of glucose in the body. This study evaluates the anti-diabetic activity of the aqueous and methanol extracts of Abelmoschus caillei in Streptozotocin-induced diabetic rats. Thirty male rats were administered with 45 mg/kg Streptozotocin (STZ) to induce-diabetes for 3 days and thereafter treated with graded oral doses of 200 and 400 mg/kg of aqueous and methanol pod extracts of A. caillei for 28 days. Hematological analysis, biochemical analysis and histopathology of the heart, were carried out using standard procedures. The results from this study showed a significant reduction in the elevated blood glucose levels at day 28 of the aqueous and methanol extracts (67.37; 130 mg/dL and 173.0; 140.0 mg/dL) with percentage reduction of (68.29; 56.3% and 30.7; 45.8%) respectively when compared with glibenclamide group and diabetes control (220.7 mg/dl; 43.98 % and 418.7 mg/dl; 0%). The hematological, lipid profile and liver function test had a slight significant difference specifically at 400 mg/kg of the extracts when compared with the control p> 0.05. The architectural frame work of the organ’s histopathology elicited no deformities in liver, kidney, pancreases, lungs, and heart the treated groups when compared with the diabetic control. This study showed that A. caillei extracts possess anti-diabetic potentials, thereby supporting the claims in the management of diabetes from the traditional folk’s report.

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Section: Discussionsupporting

confidence: 90%

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Enoyoze¹,

Idu²,

Gabriel³

2022

jcbr

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“…[18] It was also reported that AEPE possesses hypoglycemic effect against streptozotocin and alloxan-induced diabetes in rats. [19,20] In view of the forwarded mentioned facts, we decided to examine the possibility of a protective effect of AEPE against the hyperlipidemias and hyperglycemia induced by the DEXA in rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of the aqueous extract from Abelmoschus esculentus L peel on hyperglycemia and hyperlipidemia induced by dexamethasone in rats

Dugani

Alkhetally

Elghedafi

et al. 2018

Libyan International Medical University Journal

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Background: Hyperglycemia and hyperlipidemias are common clinical problem among users of glucocorticoids (GCs). The aim of the present study was to explore the effect of oral administration of the aqueous extract of Abelmoschus esculentus peel (AEPE) on hyperglycemia and hyperlipidemia induced in rats by dexamethasone (DEXA). Methods: Twenty-four rats were randomly divided into four equal groups. Each group was treated for 10 days either with 2% carboxymethylcellulose orally (normal control); 10 mg/kg DEXA subcutaneously (hyperglycemic group); 100 mg/kg AEPE orally plus 10 mg/kg DEXA subcutaneously (treatment group 1); or 200 mg/kg AEPE orally plus 10 mg/kg DEXA subcutaneously (treatment group 2). Animals were killed after 10 days of treatments by decapitation, their blood collected for the analysis of blood sugar and lipid profile. Results: Treatment with DEXA induced a significant increase in blood glucose and all lipids and a significant reduction in body weights. After 10 days of treatment, 100 mg/kg of AEPE was able to significantly reduce the effect of DEXA on triglycerides and low-density lipoprotein (LDL) only. 200 mg/kg of AEPE was able to significantly reduce the effect of DEXA on blood glucose levels, cholesterol, triglycerides, and LDL. Both doses of AEPE were able to increase high-density lipoprotein. Conclusion: This study suggests that the AEPE could be beneficial in protecting against GC-induced hyperglycemia and hyperlipidemia.

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“…This is one of the most important vegetables,which is widely grown well in both tropical and temperate zones. This plant is popular for its mucilaginous properties and acclaimed to have various health benefits which include anti-diabetic properties (Amin, 2011).…”

Section: Original Research Papermentioning

confidence: 99%

Mining of miRNAs using Next Generation Sequencing (NGS) data generated for Okra (Abelmoschus esculentus)

Gupta¹,

Gayathri²,

Radhika³

et al. 2018

J Hortic Sci

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MicroRNAs (miRNAs) are small, highly conserved non-coding RNA molecules involved in theregulation of gene expression in eukaryotes. Gene expression involves post-transcriptionalgene regulation by miRNAs. miRNAs are formed from precursor RNA molecules that fold intoa stem loop secondary structure. The mature miRNA is one end of the precursor miRNA,defined by the cut from ‘Drosha’ on either the 5’ or 3’ arm. In this study, we have used abioinformatics approach to identify miRNAs in 3,361 contigs obtained from partial genomesequence data of Abelmoschus esculentus (okra) sequenced by NGS technology. Using C-miiand psRNA Target tools, we identified two miRNAs and their target RNAs for which a regulatorymiRNA binding has been verified. Their targets consisted of transcription factors involved ingrowth and development, gene regulation and metabolism. Phylogenetic analysis of the newlyidentified miRNA family has been done to compare their level of conservation with respect tothe other members of the plant kingdom.

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Hypoglyclemic Effects in Response to Abelmoshus Esculentus Treatment: A Research Framework using STZ-Induced Diabetic Rats

Cited by 9 publications

References 36 publications

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Anti-glycemic potential of Abelmoschus caillei (A. Chev.) Stevels Pod aqueous and methanol extract on streptozotocin-induced diabetic rats

Effects of the aqueous extract from Abelmoschus esculentus L peel on hyperglycemia and hyperlipidemia induced by dexamethasone in rats

Mining of miRNAs using Next Generation Sequencing (NGS) data generated for Okra (Abelmoschus esculentus)

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