Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats

Baldissera, Matheus D.; Souza, Carine F.; Grando, Thirssa H.; Doleski, Pedro H.; Boligon, Alexandra Augusti; Stefani, Lenita M.; Monteiro, Sílvia González

doi:10.1007/s00210-016-1326-3

Cited by 53 publications

(36 citation statements)

References 39 publications

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“…In contrast to the studies described herein, other investigators have reported hypolipidemic effects of BCP [58][59][60][61]. These observations were detected, in vivo, under both hyperlipidemic and hypercholesterolemic conditions.…”

Section: Resultscontrasting

confidence: 99%

β-caryophyllene enhances the transcriptional upregulation of cholesterol biosynthesis in breast cancer cells

Mboge¹,

Bullock²,

O’Donnell³

et al. 2019

Current Topics in Biochemical Research

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Supplementary Figure LegendsSupplementary Figure Legends Supplementary Figure 1. Paclitaxel reduces growth of aggressive breast cells. Panels A and B. UFH-001, MDA-MB-231 LM2, T47D, or MCF10 A cells were exposed to specific concentrations of Paclitaxel for 24 h (Panel A) or 48 (Panel B). The MTT assay was then used to assess viability/cell growth. Data are reported as percent of control: avg ± S.E.M., n = 3. Panel C. LDH activity was measured in the medium of cells treated with specific concentrations of Paclitaxel for 32 h followed by exposure to 70 µM BCP or vehicle for 16 h. Data are reported as the avg ± S.E.M., n=3. Panel D. Under the same conditions as in Panel C, the MTT assay was performed at 48 to assess viability/cell growth. Data are presented at OD at 570: avg ± S.E.M., n = 3. Supplementary Figure 2. Cytotoxicity of BCP is not affected by hypoxia. Cells were exposed to normoxic or hypoxic condition in the presence of increasing concentrations of BCP. LDH release was measured after 16 h. Data shown represent the average of at least 3 biological replicates ± S.E.M.

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Section: Resultscontrasting

confidence: 99%

β-caryophyllene enhances the transcriptional upregulation of cholesterol biosynthesis in breast cancer cells

Mboge¹,

Bullock²,

O’Donnell³

et al. 2019

Current Topics in Biochemical Research

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show abstract

“…In contrast to the studies described herein, other investigators have reported hypolipidemic effects of BCP (58)(59)(60)(61). These observations were detected, in vivo, under both hyperlipidemic and hypercholesterolemic conditions.…”

Section: Is Cholesterol Content or Redistribution Within The Pm The Kcontrasting

confidence: 99%

β-Caryophyllene Enhances the Transcriptional Upregulation of Cholesterol Biosynthesis in Breast Cancer Cells

Mboge

Ramirez-Mata

Bullock

et al. 2019

Preprint

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β-caryophyllene (BCP) exhibits anti-proliferative properties in cancer cells. Here, we examine the hypothesis that BCP induces membrane remodeling. Our data show that high concentrations of BCP increase membrane permeability of human breast cells (hBrC) causing detachment and cell death. At a sub-lethal concentration of BCP, we show that BCP induces a striking upregulation of genes involved in cholesterol biosynthesis, including the gene that encodes for HMGCoA reductase (HMGCR), the ratedetermining step in cholesterol biosynthesis. In addition, stearoyl-CoA desaturase (SCD) is also upregulated which would lead to the enhanced formation of monounsaturated fatty acids, specifically oleate and palmitoleate from stearoyl CoA and palmitoyl CoA, respectively. These fatty acids are major components of membrane phospholipids and cholesterol esters. Together, these data suggest that cells respond to BCP by increasing the synthesis of components found in membranes. These responses could be viewed as a repair mechanism and/or as a mechanism to mount resistance to the cytotoxic effect of BCP. Blocking HMGCR activity enhances the cytotoxicity of BCP, suggesting that BCP may provide an additional therapeutic tool in controlling breast cancer cell growth.

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“…These observations are consistent, in part, with the findings of a recent study using Triton WR-1339 induced hyperlipidemia in rats. ( 38 ) This study found that BCP reduced total cholesterol, triglycerides and LDL cholesterol, did not increase HDL cholesterol, inhibited HMG-CoA reductase activity and ameliorated the antioxidant system.…”

Section: Discussionmentioning

confidence: 78%

Hypocholesterolemic effect of β-caryophyllene in rats fed cholesterol and fat enriched diet

Harb

Bustanji

Abdalla

2018

J. Clin. Biochem. Nutr.

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Hypercholesterolemia is a major risk factor for cardiovascular diseases. This study investigated the cholesterol-lowering potential of β-caryophyllene in a rat model. Hypercholesterolemia was induced by feeding male Wistar rats a high cholesterol and fat diet for 2 weeks. This was followed by oral administration of β-caryophyllene to hypercholesterolemic rats at 30, 100 and 300 mg/kg b.w. for 4 weeks. A dose of 30 mg/kg of β-caryophyllene significantly lowered serum total cholesterol, low density lipoprotein and the atherogenic index and significantly increased high density lipoprotein level. Moreover, it ameliorated liver injury as evidenced by decreasing hepatomegaly, macrovesicular steatosis and the activity of hepatic marker enzymes alanine aminotransferase and aspartate aminotransferase. Furthermore, it increased the activity of the antioxidant enzyme superoxide dismutase. This dose of β-caryophyllene significantly inhibited the activity of hepatic hydroxy-methylglutaryl coenzyme A reductase. Higher doses (100 and 300 mg/kg) of β-caryophyllene, however, did not induce significant beneficial effects on the studied parameters. These observations demonstrate that β-caryophyllene has a cholesterol-lowering effect on hypercholesterolemic rats, thus offering protection against hypercholesterolemia-induced diseases such as atherosclerosis and fatty liver.

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Hypolipidemic effect of β-caryophyllene to treat hyperlipidemic rats

Cited by 53 publications

References 39 publications

β-caryophyllene enhances the transcriptional upregulation of cholesterol biosynthesis in breast cancer cells

β-caryophyllene enhances the transcriptional upregulation of cholesterol biosynthesis in breast cancer cells

β-Caryophyllene Enhances the Transcriptional Upregulation of Cholesterol Biosynthesis in Breast Cancer Cells

Hypocholesterolemic effect of β-caryophyllene in rats fed cholesterol and fat enriched diet

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