Hypomania and depression associated with distinct neural activity for immediate and future rewards

Glazer, James; Kelley, Nicholas J.; Pornpattananangkul, Narun; Nusslock, Robin

doi:10.1111/psyp.13301

Cited by 32 publications

(3 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ANOVA yielded… an interaction with Group (F(1,74) = 6.08, p < .05, ηp2 = .08). 55 Glazer et al (2019) First, following immediate outcomes, we predicted that proneness to hypomania and depressive tendencies would be related to an elevated and blunted RewP, respectively, consistent with prior studies.…”

Section: Attenuated Interactionsupporting

confidence: 78%

A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence

Clayson

Carbine

Larson

2020

International Journal of Psychophysiology

View full text Add to dashboard Cite

Performance-monitoring event-related brain potentials (ERPs), such as the error-related negativity (ERN) and reward positivity (RewP), are advocated as biomarkers of depression symptoms and risk. However, a recent meta-analysis indicated effect size heterogeneity in the ERN and RewP literatures. Hence, advocating these ERPs as biomarkers of depression might be premature or possibly misguided due to the selective reporting of significant analyses on the part of researchers (e.g., p-hacking or omission of non-significant findings). The present study quantified the degree of selective reporting and the evidential value for a true relationship between depression and ERN and RewP using a p-curve analysis. We predicted that the ERN and RewP literatures would fail to show evidential value for a relationship between each ERP and depression. Contrary to expectations, both literatures showed evidential value, albeit weak.The statistical power of the included ERN studies was between 20% and 25%, and the statistical power of the RewP was around 27%. Taken together, these findings provide support for a relationship between these ERPs and depression, which strengthens claims that these ERPs represent candidate biomarkers of depression symptoms and risk. In light of the evidence for these relationships being weak, some recommendations moving forward include conducting a priori power analyses, increasing sample sizes to improve statistical power, assessing the internal consistency of ERP scores, and carefully planning statistical approaches to maximize power.Keywords: performance monitoring, depression, p curve, error-related negativity (ERN), reward positivity (RewP) 3 Performance-monitoring event-related brain potentials (ERPs), such as the error-related negativity (ERN) and reward positivity (RewP), are advocated as biomarkers or endophenotypes of depression symptoms and risk (e.g., Meyer, Bress, Hajcak, & Gibb, 2018;Nelson, Perlman, Klein, Kotov, & Hajcak, 2016). However, recent meta-analytic work indicates that both ERN and RewP literatures are replete with heterogenous effect sizes (Moran, Schroder, Kneip, & Moser, 2017). Although heterogeneous effect sizes might be due to known or unknown moderating factors, it is possible that heterogeneity is due to the selective reporting of significant analyses or undisclosed use of other questionable research practices (QRPs), and this possibility was not examined in the meta-analysis. If effect size heterogeneity is due to selective reporting/omission of non-significant findings or other QRPs, then advocating performancemonitoring ERPs as biomarkers of depression would be misguided or at least premature. The aim of the present registered report was to the quantify the degree of selective reporting and the evidential value for a true relationship between depression and ERN and RewP using a priori registered hypotheses and methods.

show abstract

Section: Attenuated Interactionsupporting

confidence: 78%

A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence

Clayson

Carbine

Larson

2020

International Journal of Psychophysiology

View full text Add to dashboard Cite

show abstract

“…The LPP follows the RewP in time, capturing later-stage outcome processing in reward tasks (30), and may reflect more downstream processing of output from the earlier evaluation systems (31). The LPP has frequently been examined using emotionpicture viewing tasks (28,(32)(33)(34), though more recent studies demonstrated the LPP's role in reward processing in healthy controls (HC) (35)(36)(37)(38)(39) and motivated attention to potential rewards or punishments in SZ (40). Blunted LPP following reward gains has also been associated with higher negative symptoms in a transdiagnostic sample that included schizophrenia-spectrum disorders (41).…”

Section: Introductionmentioning

confidence: 99%

Reward processing electrophysiology in schizophrenia: Effects of age and illness phase

Abram

Roach

Holroyd

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Reward processing abnormalities may underlie characteristic pleasure and motivational impairments in schizophrenia. Some neural measures of reward processing show strong age-related modulation, highlighting the importance of considering age effects on reward sensitivity. We compared event-related potentials (ERPs) reflecting reward anticipation (stimulus-preceding negativity, SPN) and evaluation (reward positivity, RewP; late-positive potential, LPP) across individuals with schizophrenia (SZ) and healthy controls (HC), with an emphasis on examining effects of chronological age, brain age (i.e., predicted age based on neurobiological measures), and illness phase.Methods: Subjects underwent EEG while completing a slot-machine task for which rewards were not dependent on performance accuracy, speed, or other preparatory demands. Slot-machine task EEG responses were compared between 54 SZ and 54 HC individuals, ages 19 to 65. Reward-related ERPs were analyzed with respect to chronological age, categorically-defined illness phase (early; ESZ versus chronic schizophrenia; CSZ), and were used to model brain age relative to chronological age.Results: Illness phase-focused analyses indicated there were no group differences in average SPN or RewP amplitudes. However, a group x reward outcome interaction revealed that ESZ differed from HC in later outcome processing, reflected by greater LPP responses following loss versus reward (a reversal of the HC pattern). While brain age estimates did not differ among groups, depressive symptoms in SZ were associated with older brain age estimates while controlling for negative symptoms.Conclusions: ESZ and CSZ did not differ from HC in reward anticipation or early outcome processing during a cognitively undemanding reward task, highlighting areas of preserved functioning. However, ESZ showed altered later reward outcome evaluation, pointing to selective reward deficits during the early illness phase of schizophrenia. Further, an association between ERP-derived brain age and depressive symptoms in SZ extends prior findings linking depression with reward-related ERP blunting. Taken together, both illness phase and age may impact reward processing in SZ, and brain aging may offer a promising, novel marker of reward dysfunction that warrants further study.

show abstract

“…A smaller RewP is linked to major depression (Belden et al, 2016;Bress et al, 2013;Liu et al, 2014;Nelson et al, 2016), more severe depressive symptoms (Bress et al, 2012;Foti & Hajcak, 2009), and substance use disorders (Joyner et al, 2019). In contrast, the RewP is enhanced in hypomania (Glazer et al, 2019;Mason, O'Sullivan, Blackburn, et al, 2012). Studies suggest that the RewP is source-localized to the striatum (Carlson et al, 2011;Foti et al, 2011) and reflects phasic increases in dopamine signaling in the frontostriatal reward circuit .…”

Section: The Reward Positivity (Rewp)mentioning

confidence: 99%

Characterizing within-person variance and menstrual cycle contributions to event-related potentials associated with positive and negative valence systems: The Reward Positivity and the Error-Related Negativity

Mulligan,

Eisenlohr-Moul,

Nagpal

et al. 2024

Preprint

View full text Add to dashboard Cite

Event-related potentials (ERPs) are widely employed as measures of transdiagnostic cognitive processes that are thought to underlie various clinical disorders (Hajcak et al., 2019). Despite their prevalent use as individual difference measures, the effects of within-person processes, such as the human menstrual cycle, on a broad range of ERPs are poorly understood. The present study leveraged a within-subject design to characterize between- and within-person variance in ERPs as well as the contribution of the menstrual cycle in two frequently studied ERPs associated with positive and negative valence systems underlying psychopathology—the Reward Positivity (RewP) and the Error- Related Negativity (ERN). Seventy-one naturally-cycling participants completed repeated EEG and ecological momentary assessments of positive and negative affect in the menstrual cycle's early follicular, periovulatory, and mid-luteal phases. We examined the mean degree of change in both ERPs, the between-person variability in the degree of change in both ERPs, and whether an individual’s degree of cyclical change in these ERPs show coherence with their degree of cyclical change in positive and negative affect recorded across the cycle. Results revealed no significant changes in positive and negative affect across the cycle and small changes in ERP amplitudes. Significant random slopes in our model revealed larger individual differences in trajectories of change in ERP amplitudes and affect, in agreement with prior evidence of heterogeneity in dimensional hormone sensitivity. Additionally, state-variance in these ERPs correlated with positive and negative affect changes across the cycle, suggesting that cycle-mediated ERP changes may have relevance for affect and behavior. Finally, exploratory latent class growth mixture modeling revealed subgroups of individuals that display disparate patterns of change in ERPs that should be further investigated.

show abstract

Hypomania and depression associated with distinct neural activity for immediate and future rewards

Cited by 32 publications

References 74 publications

A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence

A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence

Reward processing electrophysiology in schizophrenia: Effects of age and illness phase

Characterizing within-person variance and menstrual cycle contributions to event-related potentials associated with positive and negative valence systems: The Reward Positivity and the Error-Related Negativity

Contact Info

Product

Resources

About