2022
DOI: 10.1016/j.biocel.2022.106274
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Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer

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Cited by 4 publications
(7 citation statements)
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“…RAC3 was elevated in EC patients and was associated with poor clinical outcome. A negative correlation was observed between the expression of RAC3 and the infiltration levels of B cells, CD8+ T cells, macrophages, and dendritic cells in EC (51). The RAC3 gene was amplified in breast cancer and correlated with tumor size and estrogen as well as progesterone receptor positivity (52).…”
Section: Discussionmentioning
confidence: 99%
“…RAC3 was elevated in EC patients and was associated with poor clinical outcome. A negative correlation was observed between the expression of RAC3 and the infiltration levels of B cells, CD8+ T cells, macrophages, and dendritic cells in EC (51). The RAC3 gene was amplified in breast cancer and correlated with tumor size and estrogen as well as progesterone receptor positivity (52).…”
Section: Discussionmentioning
confidence: 99%
“…In endometrial cancer, RAC3 overexpression correlates with high AJCC stage, histological grade, and poor overall survival. 43 In breast cancer, patients with RAC3 overexpression exhibit significantly reduced recurrence-free survival and an increased propensity for metastasis. 44 Similarly, in prostate cancer, RAC3 is highly expressed, and patients with elevated RAC3 levels display higher Gleason scores, AJCC stage, prostate-specific antigen (PSA) levels and shorter disease-free survival.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, RAC3 enhances endometrial cancer cell proliferation and invasion by upregulating fatty acid synthase (FASN) expression. 43 In breast cancer, RAC3 facilitates cell invasion and metastasis by decreasing cell adhesion and promoting matrix degradation through the CIB1-GIT1 axis. 10 In BCa, RAC3 promotes proliferation, metastasis and invasive phenotypes via PYCR1/JAK/STAT signaling.…”
Section: Discussionmentioning
confidence: 99%
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“…diaminobenzidine tetrahydrochloride was then used to detect the HRP activity of the secondary antibody. The staining intensity was categorized stratified as follows: none (−, 0), faint (+, 1, yellow staining), moderate (++, 2, light brown staining) and strong (+++, 3, dark brown staining), the staining percentage of RAC3 was stratified as follows: 0 (0%), 1 (1–10%), 2 (11–50%), 3 (51–70%) and 4 (≥ 71%) 16 . IHC score of 0–7 is the sum of the staining percentage value and staining intensity value.…”
Section: Methodsmentioning
confidence: 99%