Hyponatremia as a Mortality Predictor of Severe Malaria: A Hospital Based Cross-sectional Study

Parida, Manoj Kumar; Thatoi, Pravat Kumar; Choudhury, Anurag; Bhuin, Subhas; Behera, Sarita; Mohanty, R. K.

doi:10.7860/jcdr/2019/39902.12561

Cited by 3 publications

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“…Malaria is a protozoal disease, in which hyponatremia is commonly observed in approximately 60% of the cases [ 73 ]. A hypothesis has been proposed that it is caused by a dysregulation of vasopressin release.…”

Section: Hyponatremia Due To Infectionsmentioning

confidence: 99%

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Hyponatremia in Infectious Diseases—A Literature Review

Królicka

Kruczkowska

Krajewska

et al. 2020

IJERPH

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Hyponatremia is one of the most common water–electrolyte imbalances in the human organism. A serum sodium concentration threshold of less than 135 mmol/L is diagnostic for hyponatremia. The disorder is usually secondary to various diseases, including infections. Our review aims to summarize the diagnostic value and impact of hyponatremia on the prognosis, length of the hospitalization, and mortality among patients with active infection. The scientific literature regarding hyponatremia was reviewed using PubMed, ClinicalKey, and Web of Science databases. Studies published between 2011 and 2020 were screened and eligible studies were selected according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and specific inclusion criteria. The most common infections that were associated with hyponatremia were viral and bacterial infections, including COVID-19 (coronavirus disease 2019). The etiology varied according to the infection site, setting and patient cohort it concerned. In several studies, hyponatremia was associated with prolonged hospitalization, worse outcomes, and higher mortality rates. Hyponatremia can also play a diagnostic role in differentiating pathogens that cause a certain infection type, as it was observed in community-acquired pneumonia. Although many mechanisms leading to hyponatremia have already been described, it is impossible with any certainty to ascribe the etiology of hyponatremia to any of them.

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Section: Hyponatremia Due To Infectionsmentioning

confidence: 99%

“…Yet, the WHO guidelines for diagnosing severe hyponatremia do not take into consideration sodium levels [ 75 ]. One of the studies identified hyponatremia as a mortality predictor, which predicted death at the cut off of 126 mEq/L with the specificity of 78.8% and sensitivity of 81.1% [ 73 ].…”

Section: Hyponatremia Due To Infectionsmentioning

confidence: 99%

Hyponatremia in Infectious Diseases—A Literature Review

Królicka

Kruczkowska

Krajewska

et al. 2020

IJERPH

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“…Hyponatremia is a common disorder that's found in severe malaria, and Parida et al, reported that Hyponatremia is associated with high mortality in severe malaria. 15 Lactate serum, is also useful on predicting the mortality of cerebral malaria, on Chaudhari et al, serum lactate was examined and high of lactate serum (>45 mg/dl) lead to high chance mortality (54% of all patients with increasing lactate died). 16 Biomarkers are often used for a lot of diseases to predict the disease.…”

Section: Reviewmentioning

confidence: 99%

Biomarkers and Prognostic Scoring in Cerebral Malaria

Pikatan

Tirtana

Seraphine

et al. 2022

MNJ

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Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality. This literature review is made up from 19 literatures consisting of journals, and book. The literature review used data base www.pubmed.com, and www.scholar.google.com using “cerebral malaria and biomarker, predictor of cerebral malaria and treatment of severe malaria”. The languages for this journal are English and Indonesian. From the collection of literatures in this literature review, severe consists of cerebral malaria, blackwater fever, acute kidney injury, pulmonary edema, electrolyte disturbance, hematology disturbance, and obstetrics emergency resulting from malaria which is postpartum hemorrhage. Cerebral malaria increases the mortality of the patient, so they have to be diagnosed early and treated precisely. Patients with infection of plasmodium falciparum and GCS<11 must be suspected as cerebral malaria. Biomarker examination such as Soluble ICAM-1, Specific muscle’s protein, Angiopoetin-1 and 2, and Plasma microparticles is the most precise way to detect malarial emergency earlier Coma Acidosis Malaria score is also found to be useful in predicting the prognosis in cerebral malaria. Early diagnosis should be made as early as possible to reduce mortality from malaria and its emergencies.

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Fluid and electrolyte pathophysiology in common febrile illness in children and the implications for clinical management

Smith,

Chua,

Papaioannou

et al. 2024

Arch Dis Child

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Achieving fluid homeostasis and the management of fluid and electrolyte complications are constants in the treatment of seriously ill children worldwide. Consensus on the most appropriate fluid strategy for unwell children has been difficult to achieve and has evolved over the last two decades, most notably in high-income countries where adverse events relating to poor fluid management were identified more readily, and official robust inquiries were possible. However, this has not been the situation in many low-income settings where fluids that are prohibited from use in high-income countries may be all that are available, local guidelines and processes to recognise adverse events are not developed, and there has been limited training on safe fluid management for front-line healthcare workers. This narrative review outlines the fluid and electrolyte pathophysiology of common febrile illnesses in children, describes the evolution of this field and concludes with implications and principles of a fluid management strategy for seriously ill children. This review was prepared as a physiological background paper to support evidence presented to the WHO Guideline Development Group for Fluid Guidelines in Children, Geneva, March 2024.

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Hyponatremia as a Mortality Predictor of Severe Malaria: A Hospital Based Cross-sectional Study

Cited by 3 publications

References 0 publications

Hyponatremia in Infectious Diseases—A Literature Review

Hyponatremia in Infectious Diseases—A Literature Review

Biomarkers and Prognostic Scoring in Cerebral Malaria

Fluid and electrolyte pathophysiology in common febrile illness in children and the implications for clinical management

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