Hyponatremia Associated With Bupropion, a Case Verified by Rechallenge

Bagley, Steven C.; Yaeger, Deborah

doi:10.1097/01.jcp.0000150232.91995.22

Cited by 23 publications

(16 citation statements)

References 3 publications

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“…However, hyponatremia is not rare condition following a treatment with SSRI and antipsychotic drugs1-5). Case reports of hyponatremia associated with SSRI began appearing in 1989.…”

Section: Discussionmentioning

confidence: 99%

“…Estimates of hyponatremia associated with SSRI and SNRI use vary from 0.5-32%. Curiously, there are only few case reports published regarding bupropion induced hyponatremia1,2). Some experts have suspected the mechanism that serotonin plays a role in regulating the secretion and release of alcoholdehydrogenase (ADH)7-9).…”

Section: Discussionmentioning

confidence: 99%

“…The drug is a non-tricyclic antidepressant and its primary pharmacological action is to inhibit norepinephrine-dopamine reuptake. Although bupropion does not act as TCA and SSRI, there are few case reports describing how bupropion is associated with hyponatremia1,2). We present a case of bupropion induced hyponatremia for the first time in the Korea.…”

Section: Introductionmentioning

confidence: 91%

“…Antidepressants, including the selective serotonin reuptake inhibitor (SSRI) and the tricyclic antidepressants (TCA) often cause hyponatremia1-5). Bupropion is an atypical antidepressant and smoking cessation aid.…”

Section: Introductionmentioning

confidence: 99%

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Hyponatremia Associated with Bupropion

Kim

Choi

Bae

et al. 2011

Electrolyte Blood Press

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Bupropion is widely used for the treatment of depressive disorder and smoking cessation. Hyponatremia, including a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), is not rare complication of treatment with antipsychotic drugs. We report a 60-year-old man who experienced severe hyponatremia after a treatment with bupropion for depressive disorder for the first time in the Korea.

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“…However, hyponatremia is not rare condition following a treatment with SSRI and antipsychotic drugs1-5). Case reports of hyponatremia associated with SSRI began appearing in 1989.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyponatremia Associated with Bupropion

Kim

Choi

Bae

et al. 2011

Electrolyte Blood Press

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“…Hyponatremia can occur with SSRIs, SNRIs, and mirtazapine. Although at least two published case reports attribute hyponatremia to bupropion, other factors that may have been responsible for the hyponatremia also were present [61,62].…”

Section: Hyponatremiamentioning

confidence: 93%

Medically serious adverse effects of newer antidepressants

Mago

Mahajan²,

Thase³

2008

Curr Psychiatry Rep

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Although safer than tricyclic antidepressants and monoamine oxidase inhibitors, the newer antidepressants may be associated with certain medically serious adverse effects, of which cardiovascular adverse effects, seizures, abnormal bleeding, hyponatremia, and agranulocytosis are discussed in this review. Data regarding the incidence and risk factors are summarized, and strategies for reducing the risk of these adverse effects and managing them are suggested. Identification of risk factors, appropriate antidepressant choice, and, when possible, careful monitoring may substantially reduce the incidence of these adverse effects and the morbidity associated with them.

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Hyponatremia Associated with the Use of Common Antidepressants in the All of Us Research Program

Mo,

Channa,

Ferrara

et al. 2024

Clin Pharma and Therapeutics

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Selective serotonin reuptake inhibitor (SSRI), serotonin‐norepinephrine reuptake inhibitor (SNRI), and norepinephrine–dopamine reuptake inhibitor (NRI) antidepressants can cause hyponatremia through syndrome of inappropriate antidiuretic hormone secretion (SIADH). This study assesses the differential risks of hyponatremia associated with commonly prescribed SSRIs (fluoxetine, paroxetine, sertraline, citalopram, escitalopram), SNRIs (duloxetine, venlafaxine) and NRI (bupropion), as well as omeprazole as a reference, with a retrospective observational cohort study in the All of Us Research Program, a national multicenter research cohort containing de‐identified electronic health records (EHR). Participants who had been prescribed monotherapy with any of eight common antidepressants were included, with each drug considered as a separate arm indexed with a start date. Events were defined as the first occurrence of a low plasma sodium measurement or a clinical diagnosis recorded for either hyponatremia or SIADH. Those who did not have events were censored at their last plasma sodium measurement. A total of 17,439 individuals were exposed to one of the eight antidepressants as monotherapy. The overall incidences for hyponatremia were 0.87% in the first 30 days and 10.5% in the first 3 years in the antidepressant arms. Compared to sertraline, duloxetine (hazard ratio [HR] = 1.37 [1.19–1.58]) and escitalopram (HR = 1.16 [1.01–1.33]) were associated with the highest overall risk of hyponatremia, and bupropion (HR = 0.83 [0.73–0.94]) and paroxetine (HR = 0.78 [0.65–0.93]) were associated with the lowest risk. The risks were unchanged after adjusting for comorbidity and polypharmacy. Such information could help guide providers in managing patients and their risks of hyponatremia when on common antidepressants.

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Hyponatremia Associated With Bupropion, a Case Verified by Rechallenge

Cited by 23 publications

References 3 publications

Hyponatremia Associated with Bupropion

Hyponatremia Associated with Bupropion

Medically serious adverse effects of newer antidepressants

Hyponatremia Associated with the Use of Common Antidepressants in the All of Us Research Program

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