Hypoplastic Anemia Associated with Ulcerative Colitis in a Child

Sharma, Bedanta; Yachha, Surender Kumar; Mishra, RC; Gupta, Deepak

doi:10.1097/00005176-199610000-00022

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…14,15 Interestingly, IBD has been independently linked to non-drug-induced aplastic anemia. 16,17 A murine model of IBD showed that intestinal inflammation exerts significant stress on HSPCs. 18 Nutritional disorders also share a link between dysregulated microbial communities and altered hematological outcomes.…”

Section: Suppression Of Hematopoiesis Associated With Dysbiosis In Humentioning

confidence: 99%

Hematopoiesis and the bacterial microbiome

Yan

Baldridge²,

King

2018

Blood

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Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.

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Section: Suppression Of Hematopoiesis Associated With Dysbiosis In Humentioning

confidence: 99%

Hematopoiesis and the bacterial microbiome

Yan

Baldridge²,

King

2018

Blood

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“…Haematological affection is commonly associated with UC. It can be due to multiple causes: blood loss, malabsorption, chronicity of UC, sepsis, associated myelodysplastic syndromes, or haemolysis [1]. Several investigators have suggested a clinical association between inflammatory bowel disease (IBD) and myelodysplastic syndrome, may be they share an immune dysfunction and impairment of T-lymphocytes activities, that contribute to peripheral blood pancytopenia and bone marrow hypoplasia [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis associated with aplastic anemia and extra intestinal manifestations: Case presentation

Maher¹,

Adel²,

Rizk³

2020

Gastroenterol Hepatol Endosc

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Association between inflammatory bowel disease (IBD) and myelodysplastic syndrome, in particular aplastic anaemia was reported with possible share a common immune dysfunction pathway. Extra intestinal manifestations of IBD are also common and usually related to the activity of IBD. We report a case of active ulcerative colitis associated with aplastic anaemia, dermatological and thromboembolic extra intestinal manifestations.

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“…Aplastic anemia, although frequently idiopathic, may be secondary to immunemediated suppression of hematopoiesis in up to half of patients. 3 The association between UC and aplastic anemia may be linked to an underlying immunological dysfunction arising from cytokines elevated in both IBD and aplastic anemia, such as interleukin-1 and tumor necrosis factor-α. 2 The immune modulators azathioprine (AZA) and its active metabolite 6-MP have been proven to be effective in both chronically active IBD and the maintenance of clinical remission.…”

Section: Discussionmentioning

confidence: 99%