Hypospadias Variants

Waterloos, Marjan; Spinoit, Anne‐Françoise

doi:10.1007/978-3-319-43310-3_24

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Hypospadias is the most frequent congenital penile anomaly that affects male external genitalia, with an incidence of approximately 1 in 250 male newborns. It is caused by tissue underdevelopment on the ventral aspect of the penis, resulting in an abnormal location of the urethral opening on the penile underside [ 1 ]. Elastosonography found deep alteration of hypospadias penile anatomy, in which the corpus spongiosum is stiffer and less elastic with less developed cavernous corpora [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity

et al. 2020

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Background Hypospadias, the most frequent congenital male external genitalia abnormality, is usually associated with curvature of the ventral penis, i.e. chordee. Abnormality of darto tissue has been suggested as the pathophysiology of chordees. Collagen is one of the most abundant fibrous proteins within the extracellular matrix. In this study, we determined the expression of collagen 1 (COL1A1) and COL6A1 in patients with hypospadias and associated them with the severity of penile curvature. Methods We included 60 children < 18 years old, consisting of 20 distal hypospadias, 20 proximal hypospadias patients, and 20 controls in our institution from 2017 – 2020. The expression of COL1A1 and COL6A1 in darto tissue was determined by reverse-transcriptase polymerase chain reaction (qPCR). The penile curvature severity was classified as mild (< 30 degrees), moderate (30–60 degrees), and severe (> 60 degrees). Results qPCR showed that COL1A1 and COL6A1 expression was significantly downregulated in the distal (0.88 (0.38–2.53) and 0.54 (0.16–4.35), respectively) and proximal 0.76 (0.33–2.57) and 0.57 (0.18–1.38), respectively) hypospadias groups compared to controls (1.85 (0.24–4.61) and 0.93 (0.17–4.06), respectively) with p-values of 0.024 and 0.018, respectively. Furthermore, there was a moderate correlation between COL1A1 and COL6A1 expression (r = 0.458, p < 0.0001). Interestingly, COL1A1 and COL6A1 were also significantly downregulated in the moderate and severe chordee groups compared to the mild chordee groups, with p-values of 0.003 and 0.037, respectively. Conclusions Aberrant COL1A1 and COL6A1 expression might affect abnormalities in darto tissue and penile curvature severity in hypospadias patients.

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Section: Introductionmentioning

confidence: 99%

The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity

et al. 2020

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Managing hypospadias in a tertiary hospital in northern Ghana: a retrospective study

Yenli,

Bimpong,

Cheyuo

et al. 2023

African Urology

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Correlation between histopathology properties of dartos tissue and the severity of penile curvature in hypospadias

Duarsa,

Tirtayasa,

Winarti

et al. 2024

Arch Ital Urol Androl

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Purpose: Hypospadias, one of the congenital anomalies commonly associated with some degrees of ventral penile curvature that may arise from malformation of dartos fascia, the chordee. Our study aims to determine the correlation between the histopathology properties of dartos fascia and the severity of ventral penile curvature in hypospadias. Materials and methods: One hundred hypospadias patients with various degrees of ventral penile curvature were included in this cross-sectional analytical study from 2020 to 2022. During hypospadias repair, ventral dartos fascia was excised and analyzed for the degree of collagen thickness and the severity of the fibrotic condition. Results: Out of 100 patients, the mean age was 6.58 + 4.28 years, who were classified as mild to moderate (66%) and severe (34%) ventral curvature cases. The analyses showed significant differences in the severity of fibrotic condition and collagen thickness of dartos fascia to the severity of penile ventral curvature with p-values of 0.002 and 0.017, respectively. Conclusions: The difference in histopathology properties of dartos fascia may affect the severity of penile curvature in hypospadias patients.

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Hypospadias Variants

Cited by 3 publications

References 26 publications

The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity

The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity

Managing hypospadias in a tertiary hospital in northern Ghana: a retrospective study

Correlation between histopathology properties of dartos tissue and the severity of penile curvature in hypospadias

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