Hypotensive drugs

Tester-Dalderup, C.B.M.

doi:10.1016/s0378-6080(78)80024-5

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1979

1981

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“…Guanabenz is a highly selective a2-adrenoceptor agonist (Doxey & Hersom, 1980) which like clonidine is believed to lower blood pressure via actions on central a-adrenoceptors (Baum & Shropshire, 1976). Guanabenz, in common with clonidine causes sedation in man (Tester-Dalderup, 1977). In this study, therefore, the cardiovascular and behavioural effects of guanabenz and clonidine have been compared in female normotensive Sprague Dawley rats (> 180 g).…”

Section: Pmentioning

confidence: 99%

PROCEEDINGS OF THE British Pharmacological Society 10th‐12th September, 1980

1981

British J Pharmacology

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* Imipramine was added to the homogenate otherwise the animals were identical to the control group. ** Uptake is expressed per 10 mg cortical protein. References COPPEN, A., RAMA RAO, V.A.. SWADE, C. & WOOD, K. (1979). Inhibition of 5-hydroxytryptamine reuptake by amitriptyline and zimelidine and its relationship to their therapeutic action. Psychopharmacology, 63, 125-129. DICKISON, S.E., DIGGORY, G.L., WOOD, M.D. & WYLLIE, M.G. (1980). The effects of a selective uptake blocker on 5-HT turnover in the CNS. Br. J. Pharmac., proceedings in press. GRAY, E.G. & WHITTAKER, V.P. (1962). The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation.

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Section: Pmentioning

confidence: 99%