Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Eede, Filip Van Den; Moorkens, Greta; Houdenhove, Boudewijn Van; Cosyns, Paul; Claes, Stephan

doi:10.1159/000104468

Cited by 110 publications

(57 citation statements)

References 85 publications

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“…Moreover, the model associated the syndrome with the minor allele of 5HTT_7911132, a SNP that belongs to a gene that decreases the level of active serotonin when the allelic variants with increased transcriptional activity are present (21). Taken together, these findings agree with an additive effect that leads to a lower level of cortisol (22,23) and to alterations in the neurotransmission and in the immune function (24, 25) already described in the chronic fatigue syndrome (Figure 4). …”

Section: Discussionsupporting

confidence: 89%

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Cifuentes

Barreto

2011

biomedica

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Introduction:The different ways for selecting single nucleotide polymorphisms have been related to paradoxical conclusions about their usefulness in predicting chronic fatigue syndrome even when using the same dataset. Objective: To evaluate the efficacy in predicting this syndrome by using polymorphisms selected by a supervised approach that is claimed to be a method that helps identifying their optimal profile. Materials and methods: We eliminated those polymorphisms that did not meet the Hardy-Weinberg equilibrium. Next, the profile of polymorphisms was obtained through the supervised approach and three aspects were evaluated: comparison of prediction accuracy with the accuracy of a profile that was based on linkage disequilibrium, assessment of the efficacy in determining a higher risk stratum, and estimating the algorithm influence on accuracy. Results: A valid profile (p<0.01) was obtained with a higher accuracy than the one based on linkage disequilibrium, 72.8 vs. 62.2% (p<0.01). This profile included two known polymorphisms associated with chronic fatigue syndrome, the NR3C1_11159943 major allele and the 5HTT_7911132 minor allele. Muscular pain or sinus nasal symptoms in the stratum with the profile predicted V with a higher accuracy than those symptoms in the entire dataset, 87.1 vs. 70.4% (p<0.01) and 92.5 vs. 71.8% (p<0.01) respectively. The profile led to similar accuracies with different algorithms. Conclusions: The supervised approach made it possible to discover a reliable profile of polymorphisms associated with this syndrome. Using this profile, accuracy for this dataset was the highest reported and it increased when the profile was combined with clinical data.

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Section: Discussionsupporting

confidence: 89%

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Cifuentes

Barreto

2011

biomedica

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“…Dette kan støtte oppunder at psykonevroimmunologiske forhold kan spille en rolle ved CFS/ME (32) . Hormonelle forstyrrelser er påvist, spesielt for stressfysiologiske mekanismer som involverer HPA-aksen (hypothalamus -hypofyse -binyrebark-aksen) (33,34) . Undersøkelser av pasienter med CFS/ME før og etter fysisk anstrengelse, kan tyde på at de har en endret genregulering etter belastning i forhold til friske (35,36) .…”

Section: Utløsende Faktorerunclassified

T. Egeland og medarbeidere svarer:

Egeland¹,

Angelsen²,

Haug³

et al. 2015

Tidsskriftet

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Forfattere:Avdeling rehabilitering og sjeldne tilstander Trykk og layout: Andvord Grafisk as forord Helsedirektoratet har «følge med ansvar» for å vurdere utvikling av tjenestetilbud og om dette står i forhold til pasientgruppenes behov.På bakgrunn av erfaringer fra kontakter med pasienter, pårørende og fagpersoner er direktoratet gjort kjent med at barn, unge og voksne med CFS/ME og deres pårørende møter store utfordringer som i for liten grad ivaretas av tjenesteapparatet.Helsedirektoratets mål med denne veilederen er å bidra til faglig forsvarlighet, god kvalitet på tjenestene og tilnaermet likhet i tilbudet uansett hvor man bor som pasient med CFS/ME.Å gi helsetjenester til brukere som ikke har en klar og entydig anerkjent årsak til sin sykdom, stiller store krav til faglig kvalitet, profesjonalitet og utøvelse av tjenestetilbudet. Tidlig og riktig diagnose er viktig i et pasientforløp.Mange pasienter oppgir at de får et bedre liv når de har fått korrekt diagnose, aksepterer sykdommen og laerer seg gode mestringsstrategier for de utfordringer CFS/ME kan gi.Veilederen er utarbeidet slik at den favner et bredt felt av temaer.Veilederen bygger på dagens kunnskap og erfaring, de ordninger som er etablert i dag og gjeldende rettsregler. Det er lagt vekt på at dette først og fremst skal vaere en faglig veileder for helsepersonell.Veilederen vil bli revidert i takt med ny kunnskap.

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“…Some of these include metabolic and mitochondrial deficiencies, exposure to environmental toxins, dysautonomia associated with orthostatic intolerance, autoimmune reactions, neuroendocrine aberrations in the hypothalamic-pituitary-adrenal (HPA) axis, and chronic viral infections [4][5][6][7][8][9]. The terms myalgic encephalomyelitis (ME), chronic fatigue immune dysfunction syndrome (CFIDS), and postviral fatigue syndrome (PVFS) are used to reflect the complex of abnormalities observed in CFS.…”

Section: Burdzinski 563mentioning

confidence: 99%

"Flowers" in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

Burdzinski¹

2014

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. The presence of the erythrocyte pairs abated with the patient's recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature. Conclusion: A novel erythrocyte "flower" formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immune-mediated agglutination, possibly stemming from viral infection. IJCRI publishes(This page in not part of the published article.)

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Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Cited by 110 publications

References 85 publications

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

T. Egeland og medarbeidere svarer:

"Flowers" in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

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