Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

Zhou, Qian; Fu, Xin; Xu, Jianhui; Dong, Shiming; Liu, Changhao; Cheng, Di; Gao, Cuicui; Huang, Minhua; Liu, Zhiduo; Ni, Xinyan; Hua, Rong; Tu, Hongqing; Sun, Hongbin; Shen, Qiwei; Chen, Baoting; Zhang, Jin; Zhang, Liye; Yang, Haitao; Hu, Ji; Yang, Wei; Yao, Qiyuan; Sheng, Xing; Zhang, Jie; Yang, Weifeng; Shen, Wei

doi:10.1016/j.neuron.2022.11.008

Cited by 21 publications

(13 citation statements)

References 87 publications

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“…This difference may be caused by the different optical reflectance on Si surfaces with and without AuNPs. Under continuous irradiance, the thermal effects should be mitigated in order to avoid irreversible tissue damage induced by prolonged overheating ( 38, 39 ). For a 5-s pulse duration and varied intensity from 2.5 to 12.5 W/cm 2 , the temperature change is between ∼1 K and ∼5 K, revealed by both experimental and simulation results (Figs.…”

Section: Resultsmentioning

confidence: 99%

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

Fu,

Hu,

et al. 2024

Preprint

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The development of advanced neural modulation techniques is crucial to neuroscience research and neuroengineering applications. Recently, optical-based, non-genetic modulation approaches have been actively investigated to remotely interrogate the nervous system with high precision. Here, we show that a thin-film, silicon (Si)-based diode device is capable to bidirectionally regulate in vitro and in vivo neural activities upon adjusted illumination. When exposed to high-power and short-pulsed light, the Si diode generates photothermal effects, evoking neuron depolarization and enhancing intracellular calcium dynamics. Conversely, low-power and long-pulsed light on the Si diode hyperpolarizes neurons and reduces calcium activities. Furthermore, the Si diode film mounted on the brain of living mice can activate or suppress cortical activities under varied irradiation conditions. The presented material and device strategies reveal an innovated optoelectronic interface for precise neural modulations.

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Section: Resultsmentioning

confidence: 99%

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

Fu,

Hu,

et al. 2024

Preprint

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“… 39 However, it is notable that the TRPC4 channel is not known to have temperature-responsive cation channel activity, and calcium imaging experiments done by the authors in human embryonic kidney cells cells also did not reveal temperature-dependent channel opening of TRPC4. 39 …”

Section: Main Textmentioning

confidence: 91%

“… 38 This functional diversity may explain why not all TRP sensors involved in thermal computations are temperature sensitive, e.g., TRPC4 appears necessary for sensing warm temperatures within the preoptic area of the hypothalamus (POA), but the channel itself is not a temperature sensor. 39 …”

Section: Main Textmentioning

confidence: 99%

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Vertebrate behavioral thermoregulation: knowledge and future directions

Cutler,

Haesemeyer

2024

Neurophoton.

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. Thermoregulation is critical for survival across species. In animals, the nervous system detects external and internal temperatures, integrates this information with internal states, and ultimately forms a decision on appropriate thermoregulatory actions. Recent work has identified critical molecules and sensory and motor pathways controlling thermoregulation. However, especially with regard to behavioral thermoregulation, many open questions remain. Here, we aim to both summarize the current state of research, the “knowledge,” as well as what in our mind is still largely missing, the “future directions.” Given the host of circuit entry points that have been discovered, we specifically see that the time is ripe for a neuro-computational perspective on thermoregulation. Such a perspective is largely lacking but is increasingly fueled and made possible by the development of advanced tools and modeling strategies.

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“… 1 Notably, OPN4dC does not require high-power light, which could artificially increase the temperature in tissue. 6 Since the preoptic area (POA) contains warm-sensitive neurons, which endogenously decrease the body temperature when activated, 7 , 8 stimulating light for optogenetics needs to be weak enough not to produce heat by light-illumination itself, leading to activation of these warm-sensitive neurons.…”

Section: Before You Beginmentioning

confidence: 99%

Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state

2023

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Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

Cited by 21 publications

References 87 publications

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

Vertebrate behavioral thermoregulation: knowledge and future directions

Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state

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