Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion

Ferrara, Andrea; MacArthur, J. D.; Wright, Hastings K.; Modlin, Irvin M.; McMillen, Marvin A.

doi:10.1016/s0002-9610(05)81018-9

Cited by 348 publications

(111 citation statements)

References 15 publications

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“…Rewarming of the patient should be considered prior to transfusion given the risks (34) and expense of blood transfusion. Furthermore, once a hypothermia-induced hemorrhagic diathesis develops, transfusion of platelets or plasma is relatively ineffective (5). The present data suggest that rewarming the patient will result in better function of transfused platelets.…”

mentioning

confidence: 65%

Reversible Hypothermia-Induced Inhibition of Human Platelet Activation in Whole Blood in Vitro and in Vivo

Michelson¹,

Macgregor²,

Kestin³

et al. 1992

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mentioning

confidence: 65%

Reversible Hypothermia-Induced Inhibition of Human Platelet Activation in Whole Blood in Vitro and in Vivo

Michelson¹,

Macgregor²,

Kestin³

et al. 1992

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“…Platelet counts likewise do not give any indication of the adequacy of platelet function. This further emphasizes the importance of rewarming in the acute phase of the treatment of trauma patients (9,11). Aggressive rewarming to achieve normothermia in severely injured patients is a critical component of improving coagulopathy and restoring normal physiologic function.…”

Section: Discussionmentioning

confidence: 99%

Active Intravascular Rewarming for Hypothermia Associated with Traumatic Injury: Early Experience with a New Technique

Taylor¹,

Carroll²,

Lovitt³

et al. 2007

Baylor University Medical Center Proceedings

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“…A higher rate of infection and worsening of coagulation have been reported in some clinical studies of hypothermia in neurotrauma [158], [159] and [160]. These complications, however, have not constituted a major problem in the majority of randomized studies [19], [20], [24] and [161], have been absent so far in ALF patients [80], [81], [119] and [120] and, importantly, they can be prevented and managed.…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Keeping cool in acute liver failure: Rationale for the use of mild hypothermia

Vaquero

Rose

Butterworth

2005

Journal of Hepatology

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Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, there is currently a paucity of effective therapies. Mirroring its cerebro-protective effects in other clinical conditions, the induction of mild hypothermia may provide a potential therapeutic approach to the management of ALF. A solid mechanistic rationale for the use of mild hypothermia is provided by clinical and experimental studies showing its beneficial effects in relation to many of the key factors that determine the development of brain edema and intracranial hypertension in ALF, namely the delivery of ammonia to the brain, the disturbances of brain organic osmolytes and brain extracellular amino acids, cerebro-vascular haemodynamics, brain glucose metabolism, inflammation, subclinical seizure activity and alterations of gene expression. Initial uncontrolled clinical studies of mild hypothermia in patients with ALF suggest that it is an effective, feasible and safe approach. Randomized controlled clinical trials are now needed to adequately assess its efficacy, safety, clinical impact on global outcomes and to provide the guidelines for its use in ALF.

show abstract

Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion

Cited by 348 publications

References 15 publications

Reversible Hypothermia-Induced Inhibition of Human Platelet Activation in Whole Blood in Vitro and in Vivo

Reversible Hypothermia-Induced Inhibition of Human Platelet Activation in Whole Blood in Vitro and in Vivo

Active Intravascular Rewarming for Hypothermia Associated with Traumatic Injury: Early Experience with a New Technique

Keeping cool in acute liver failure: Rationale for the use of mild hypothermia

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