“…Alternatively, lithium can exert this disturbance by initiating cellular hypothyroidism (Bolaris, Margarity, & Valcana, ), reducing the birth weight (Harari et al, ), decreasing the energy balance (Brietzke, Stabellini, Grassi‐Oliveira, & Lafer, ), increasing cytokine imbalances (Grignon & Bruguerolle, ) and activating DNA fragmentation in cerebrum of rats (Shao, Young, & Wang, ). In addition, hypothyroidism impairs development of the monoaminergic system (Ahmed, Abdel‐Latif, Mahdi, et al, ; Ibrahim, Tousson, El‐Masry, Arafa, & Akela, ; Tousson, Ibrahim, Arafa, & Akela, ), causing a pathophysiological status (Van Herck et al, ) and neurodevelopmental disorders (Andersen et al, ; Gilbert, Goodman, Gomez, Johnstone, & Ramos, ; O'Shaughnessy et al, ; Salazar, Cisternas, Martinez, & Inestrosa, ; Thompson et al, ). Thus, the potent variations in the monoamine levels might be an adaptive mechanism to achieve homeostasis in the body following the hypothyroid state induced by LiCl.…”