Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis

Wang, Shiming; Liu, Yue; Zheng, Guangying

doi:10.1371/journal.pone.0186634

Cited by 21 publications

(22 citation statements)

References 33 publications

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“…Among the 52 included eligible MAs, 4628–73 (46/52, 88.5%) were published in English, and the rest74–79 (6/52, 11.5%) were published in Chinese. The 52 included MAs contained 685 studies, with an average of 13.2 (range: 3–39) studies per article.…”

Section: Resultsmentioning

confidence: 99%

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Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Tian¹,

Shao²,

Qin³

et al. 2019

BMJ Open

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ObjectivesThere is an increasing prevalence of hypothyroidism and there is a growing body of meta-analyses (MAs) on the association between hypothyroidism and other diseases. However, the methodological quality of the MAs significantly varies. Thus, this study aimed to evaluate and summarise data on the methodological quality of MAs on the associations between hypothyroidism and other diseases using the Assessment of Multiple Systematic Reviews (AMSTAR) scale, providing suggestions for clinical decision-making processes.DesignTo assess the methodological quality of MAs using the AMSTAR scale.Data sourcesA systematic literature search was performed in PubMed, EMBASE, the Cochrane Library, web of science and Chinese Biomedicine Literature Database.Eligibility criteriaWe included MAs that had assessed the association between hypothyroidism and other diseases in humans and that had full texts regardless of the publication status. No restriction applied on language or date.Data extraction and synthesisTwo reviewers independently screened the titles and abstracts of all searched literature to acquire potentially eligible publications. The full texts of possible eligible publications were downloaded and assessed. Inconsistent comments were resolved through discussions with a third reviewer.Results52 studies were included. The average AMSTAR score of the included articles was 8.6 (range: 5–10), and those of English and Chinese MAs were 8.8 and 7.0, respectively. A total of 52 MAs were evaluated, and 19 (36.5%) and 33 (63.5%) of these MAs were of moderate and high quality, respectively. None of the MAs were of low quality. Only two MAs had an a priori design. Items 3, 5 and 9 had the highest compliance (50/52, 96.2%), and aside from item 1, items 7 and 8 had the lowest compliance (33/52,63.5%). According to the results of these MAs, hypothyroidism was significantly associated with cardiovascular diseases, metabolic diseases, neuropsychiatric disorders, breast cancer and pregnancy outcome.ConclusionsThe methodological quality of the included MAs on the association between hypothyroidism and other diseases was moderate to high. MAs with high qualities confirmed that hypothyroidism was significantly associated with cardiovascular diseases, metabolic syndrome, preterm birth and neonatal outcomes. Consideration of scientific quality when formulating conclusions should be made explicit and more attention should be paid to improving the methodological quality of MAs, and increasing their applicability for clinical decision-making.

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Section: Resultsmentioning

confidence: 99%

“…Ten39 40 43 49 57 58 65 68–70 MAs were about the associations between OH and other diseases, and 3528–36 38 42 44–47 50–56 59–64 66 67 75–79 MAs have shown the associations between SCH and other diseases. Seven37 41 48 71–74MAs have investigated the effects of both OH and SCH on other diseases.…”

Section: Resultsmentioning

confidence: 99%

Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Tian¹,

Shao²,

Qin³

et al. 2019

BMJ Open

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“…Zusätzlich sind Störungen in der Schilddrüsenfunktion beschrieben worden. Während für die endokrine Orbitopathie keine erhöhte Assoziation zum POWG nachgewiesen werden konnte [33 -35], zeigte sich in einer Metaanalyse die Hypothyreose als ein Risikofaktor für das POWG [36]. Als Ursachen käme eine hypothalamische Störung oder auch z.…”

Section: Stoffwechselstörungenunclassified

Sekundäre Neuroprotektion beim Glaukom durch ergänzende medikamentöse Therapiekonzepte

Erb

2020

Klin Monatsbl Augenheilkd

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ZusammenfassungDas primäre Offenwinkelglaukom (POWG) wird derzeit als eine neurodegenerative Systemerkrankung angesehen. Die alleinige individualisierte Augeninnendrucksenkung wird dabei dem komplexen Geschehen im chronischen Verlauf der Erkrankung nicht gerecht werden, sodass begleitende medikamentöse Therapiekonzepte sinnvoll sind. Anhand von 4 Therapiestrategien, wie die Verbesserung der mitochondrialen Atmungskette mit Coenzym Q10, die Stabilisierung der mitochondrialen und zellulären Plasmamembranen mit Citicolin, die Verminderung des oxidativen Stresses am Auge und im Körper mit Curcumin und die Verbesserung des Fettstoffwechsels, speziell des LDL-Cholesterins, mit der Anwendung der Statine, soll ein Einblick in mögliche additive Therapieansätze gegeben werden. Da neuroprotektive Therapien als Monotherapien wenig erfolgversprechend sein dürften, werden sie eher in der Kombination aus verschiedenen Therapieansätzen bestehen.

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“…Research provides conflicting results regarding the link between hypothyroidism and glaucoma. Two recent reviews and meta-analyses (6,7) showed that the risk of glaucoma is significantly higher in patients with hypothyroidism -one of them analysed glaucoma in general (6) and another one POAG only (7). On the other hand, there is no increased risk of hypothyroidism in patients with glaucoma (6).…”

Section: Hypothyroidismmentioning

confidence: 99%

“…According to a hypothesis postulated by Smith et al (1992), hypothyroidism is associated with increased deposition of muco polysaccharides and hyaluronic acid in the trabecular meshwork, which leads to decreased aqueous outflow and results in intraocular pressure elevation (6,7). Additionally, both conditions might be linked with autoimmunity and there is a possibility of shared genetic autoimmune predisposition (6).…”

Section: Hypothyroidismmentioning

confidence: 99%

Selected glaucoma risk factors and their role in disease progression. Part I – systemic, local and mechanical factors

Kosny¹,

Jurowski²

2018

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Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis

Cited by 21 publications

References 33 publications

Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Sekundäre Neuroprotektion beim Glaukom durch ergänzende medikamentöse Therapiekonzepte

Selected glaucoma risk factors and their role in disease progression. Part I – systemic, local and mechanical factors

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