Hypothyroidism associated with therapy for multi‐drug‐resistant tuberculosis in Australia

Cheung, Yee-Ming Melody; Van, Karen; Lan, Lan; Barmanray, Rahul; Qian, Sarah; Shi, William Y.; Wong, Jennifer L.; Hamblin, Peter S; Colman, Peter G; Topliss, Duncan J.; Denholm, Justin T.; Grossmann, Mathis

doi:10.1111/imj.14085

Cited by 8 publications

(8 citation statements)

References 23 publications

(42 reference statements)

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“…Studies included in this review were reported from 19 countries which cover three continents (Africa, Asia and Europe) [Table 1]. Seventeen studies were reported from Asian [32,34–40,42–44,46,48,53,54,60,61], eight from African [41,45,47,49,50,55,57,58] and five from European [33,48,52,56,59] countries. We categorized Russia, Turkey and Ukraine under European countries category.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies [32,36,37,39,51,54] used immunoassay based techniques as the method to measure TSH concentration, while 14 studies [38,41,42,44,46,47,49,55–61] retrieved the value of TSH concentration from record (treatment card or laboratory report). However, ten studies [33–35,40,43,45,48,50,52,53] did not report how TSH concentration was measured, and from where data on TSH concentration was collected.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reported HIV sero-reactive status of the participants with the pooled prevalence of HIV co-infection with MDR-TB was 30.0% (95% CI: 21.0–40.0). Analysis from six studies shown that the pooled prevalence of pulmonary TB was 89.0% (95% CI: 84.0–93.0)[37,38,42,46,49,61], while the pooled prevalence of extra-pulmonary TB as estimated from the same six studies was 12.0% (95% CI: 7.0–17.0).…”

Section: Resultsmentioning

confidence: 99%

“…Ethionamide and PAS were the most frequently reported drugs that are associated with hypothyroidism [Table 2]. Four studies [37,42,50,51] reported the proportion of hypothyroidism by sex, and we pooled the odds ratio of these four studies to assess the effect of sex on the thyroid hormone in MDR-TB patients on treatment. As a result, the pooled odds ratio between female and male was 0.534 (95% CI 0.262–1.09) by considering female as risk category.…”

Section: Resultsmentioning

confidence: 99%

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Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis

et al. 2019

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Background Hypothyroidism is one of the adverse drug reactions that associated with Multidrug Resistant Tuberculosis (MDR-TB) medications. Extremely variable magnitude of hypothyroidism in MDR-TB patients has been reported from different parts of the world. However, there is no evidence that tried to estimate the pooled prevalence of hypothyroidism to confirm the rareness of hypothyroidism in MDR-TB patients on treatment. Therefore, we did a systematic review and meta-analysis to estimate the prevalence of hypothyroidism in MDR-TB patients on treatment, and to summarize the demographic and clinical characteristics of the patients. Methods We conducted a systematic review and meta-analysis on studies reported around the world on the prevalence of hypothyroidism in MDR-TB patients on treatment. We searched electronic databases: PubMed/Medline, EMBASE, CINAHL, Science Direct, Academic Search Complete and Google scholar for English language articles without limiting publication year. We also reviewed the bibliographies of relevant studies and conducted an electronic search for relevant conference abstracts. Eligible studies were cross-sectional and cohort studies that included at least five participants. We used a random-effects model to estimate the pooled prevalence of hypothyroidism. The registration number of this review study protocol is CRD42018109237. Results We included 30 studies and pooled data on a total of 6,241 MDR-TB patients. The crude prevalence of hypothyroidism was extremely heterogeneous. The pooled prevalence of hypothyroidism in MDR-TB patients on treatment was 17.0% (95% CI: 13.0–20.0). Ethionamide and para-aminosalicylic acid (PAS) were the most frequently reported drugs that associated with the occurrence of hypothyroidism. Conclusion This review revealed that hypothyroidism is not a rare adverse drug reaction in MDR-TB patients on treatment. Ethionamide and PAS were the most frequently reported drugs that associated with the occurrence of hypothyroidism. Screening of hypothyroidism in MDR-TB patients on treatment is important while targeting patients on Ethionamide and PAS based treatment regimen.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis

et al. 2019

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“…This finding was similar with the study reported by Ben-nan et al in 2020 (71.4%) from China in which prothionamide and para-aminosalicylic acid were significantly associated with hypothyroidism. 25 Moreover, the study reported by Cheung et al (2019) from Australia 34 indicated the significant association between prothionamide and hypothyroidism in MDR-TB patients on treatment.…”

Section: Discussionmentioning

confidence: 98%

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Biranu¹,

Wolde²,

Negesso³

et al. 2021

IDR

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Background:The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. Objective: To determine thyroid profiles and associated risk factors among multidrugresistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. Conclusion: Hypothyroidism occurs commonly among MDR-TB patients. Presence of comorbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication.

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Sodium-aminosalicylate/protionamide

2020

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Hypothyroidism associated with therapy for multi‐drug‐resistant tuberculosis in Australia

Cited by 8 publications

References 23 publications

Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis

Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Sodium-aminosalicylate/protionamide

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