Hypouricemic and arthritis relapse-reducing effects of compound tufuling oral-liquid in intercritical and chronic gout

Abstract

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The Impact of Natural Product Dietary Supplements on Patients with Gout: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

“…A total of nine RCTs with 1156 participants were included in this review. Seven trials were conducted in China [20][21][22][23][24][25][26], 1 in the USA [27], and 1 in New Zealand [28]. All the studies were published from 2008 to 2019.…”

“…Seven studies evaluated herbal therapies, with the remaining two evaluating skim milk and cherry extract. Six trials had two arms; [20,25], one adopted the random envelope method [21], and the other used online computer random number generator [27]. e other two trials had an unclear risk for random sequence generation due to lack of detail [23,26].…”

“…Two trials had unclear randomization without description in sufficient detail [23,26]. Five trials had lower risk bias for allocation concealment [21,22,24,27,28]. ree trials were doubleblinded trials with a lower risk for blinding participants and study personnel [21,22,28].…”

“…Five trials had lower risk bias for allocation concealment [21,22,24,27,28]. ree trials were doubleblinded trials with a lower risk for blinding participants and study personnel [21,22,28]. Two trials did not use a blinding method to participants and study personnel during the study with a high risk due to the great appearance difference between Chinese medical formulation pills and decoction with conventional pharmaceutics such as indomethacin, benzbromarone, and allopurinol [20,25].…”

“…e other four trials had insufficient information to permit a judgment [23,24,26,27]. ree trials could be regarded as lower risk for blinding of outcome assessors [20][21][22]. One trial had high risk in outcome assessment due to a lack of blinding [25].…”