Hypoxia differentially regulates stress proteins in cultured cardiomyocytes Role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection

Abstract

These data show a differential pattern of hypoxia-induced HSP expression and implicate the stress kinase in HO-1 induction. Thus, selective regulation of HSP levels may play a role in the cardioprotective mechanisms that participate in the adaptive response to hypoxia-induced stress.

Deletion of Caveolin-1 Protects against Oxidative Lung Injury via Up-Regulation of Heme Oxygenase-1

“…For example, IL-10-and TGF-b-mediated induction of HO-1 expression involved activation of p38 MAPK (50,51). The regulation of HO-1 by hypoxia preferentially involved p38 MAPK signaling in cardiomyocytes (52). The up-regulation of HO-1 by photosensitizer-mediated oxidative stress in cancer cells and its associated anti-apoptotic activity was mediated in part by p38 MAPK (53).…”

TGF-β1stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells

“…For example, the ERK1/ERK2 and p38 MAPK pathways mediated the sodium arsenite-dependent induction of ho-1 gene transcription in avian hepatoma cells (14) and in HeLa cells after exposure to nitric oxide donors (8). The p38 MAPK but not ERK1/ERK2 pathways mediated the regulation of ho-1 transcription by CdCl 2 in MCF-7 cells (3) and by hypoxia in cardiomyocytes (17). On the other hand, the induction of HO-1 expression in rat liver by phorone, a glutathione-depleting agent, was associated with JNK activation (31).…”

Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases

“…The regulation of HO-1 expression by these factors is not only cell type-dependent but also species-dependent [162,164]. For example, hypoxia induces HO-1 expression in rodent, bovine and monkey cells, but represses HO-1 expression in several human cell lines, including lung cancer A549 cells, umbilical vein endothelial cells and glioblastoma cells [72,[165][166][167][168][169][170]. A detailed discussion of HO-1 regulation can be found in an excellent review written by Sikorki et al [162].…”