Hypoxia in Cell Reprogramming and the Epigenetic Regulations

Nakamura, Nariaki; Shi, Xiaobing; Darabi, Radbod; Li, Yong

doi:10.3389/fcell.2021.609984

Cited by 30 publications

(29 citation statements)

References 101 publications

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“…Thus, an altered shear stress has been associated with the development of atherosclerosis [ 268 ]. In the same line, other mechanisms, such as hypoxia or inflammation, might induce the epigenetic reprogramming of the vascular cells, which in turn enhance the inflammatory and hypoxic responses [ 269 , 270 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Ortega

Fraile-Martínez

García-Montero

et al. 2021

JCM

119

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Chronic venous disease (CVD) is a multifactorial condition affecting an important percentage of the global population. It ranges from mild clinical signs, such as telangiectasias or reticular veins, to severe manifestations, such as venous ulcerations. However, varicose veins (VVs) are the most common manifestation of CVD. The explicit mechanisms of the disease are not well-understood. It seems that genetics and a plethora of environmental agents play an important role in the development and progression of CVD. The exposure to these factors leads to altered hemodynamics of the venous system, described as ambulatory venous hypertension, therefore promoting microcirculatory changes, inflammatory responses, hypoxia, venous wall remodeling, and epigenetic variations, even with important systemic implications. Thus, a proper clinical management of patients with CVD is essential to prevent potential harms of the disease, which also entails a significant loss of the quality of life in these individuals. Hence, the aim of the present review is to collect the current knowledge of CVD, including its epidemiology, etiology, and risk factors, but emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments. Furthermore, future directions will also be covered in this work in order to provide potential fields to explore in the context of CVD.

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Section: Pathophysiologymentioning

confidence: 99%

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Ortega

Fraile-Martínez

García-Montero

et al. 2021

JCM

119

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“…Some reprogramming modulators include tumor suppressor protein, cell signaling modifiers, and hypoxia [59][60][61][62][63][64]. Cellular reprogramming efficiency can be increased by transient inhibition of the phosphatase and tensin homolog protein (PTEN) or tumor protein 53 (TP53) tumor suppressor gene.…”

Section: Factors and Pathways In Cancer Cell Reprogrammingmentioning

confidence: 99%

Cancer cells as a new source of induced pluripotent stem cells

et al. 2022

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Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential applications in various medical research areas, from personalized medicine to disease treatment. Different cellular resources are accessible for iPSC generation, such as keratinocytes, skin fibroblasts, and blood or urine cells. However, all these sources are somatic cells, and we must make several changes in a somatic cell’s transcriptome and chromatin state to become a pluripotent cell. It has recently been revealed that cancer cells can be a new source of iPSCs production. Cancer cells show similarities with iPSCs in self-renewal capacity, reprogramming potency, and signaling pathways. Although genetic abnormalities and potential tumor formation in cancer cells pose a severe risk, reprogrammed cancer-induced pluripotent stem cells (cancer-iPSCs) indicate that pluripotency can transiently overcome the cancer phenotype. This review discusses whether cancer cells can be a preferable source to generate iPSCs.

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“…One example is the changes in the oxygen level and the presence of hypoxia. Hypoxia‐inducible factors are major players of this scenario which can modulate cellular epigenetics 31 . They can modify DNA methylation by changing the level of universal methyl donor, S‐adenosylmethionine, 32 affecting expression of DNMTs, 33 or even cause histone modifications by altering the expression of histone modifiers 34 …”

Section: Epigenetic Inheritance and Its Role In Cell Fate Determinationmentioning

confidence: 99%

Role of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy

Darabi

2021

J of Cellular Biochemistry

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Epigenetics play a fundamental role in induced pluripotent stem cell (iPSC) technology due to their effect on iPSC's reprogramming efficiency and their subsequent role in iPSC differentiation toward a specific lineage. Epigenetics can skew the differentiation course of iPSCs toward a specific lineage based on the epigenetic memory of the source cells, or even lead to acquisition of new cell phenotypes, due to its aberrations during reprogramming. This viewpoint discusses key features of the epigenetic process during iPSC reprogramming/differentiation and outlines important epigenetic factors that need to be considered for successful generation and differentiation of iPSCs for downstream applications.

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Hypoxia in Cell Reprogramming and the Epigenetic Regulations

Cited by 30 publications

References 101 publications

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

Cancer cells as a new source of induced pluripotent stem cells

Role of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy

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