Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

Abstract

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues, and organs. Under extended exposure to reduced oxygen levels, cells are able to survive through the transcriptional activation of a series of genes that participate in angiogenesis, glucose metabolism, and cell proliferation. The oxygen-sensitive transcriptional activator HIF-1 (hypoxia-inducible factor-1) is a key transcriptional mediator of the response to hypoxic conditions. The HIF-1 pathway was found to be a master regulator of angiogenesis. Whether the process is physiological or pathological, HIF-1 seems to participate in vasculature formation by synergistic correlations with other proangiogenic factors such as VEGF (vascular endothelial growth factor), PlGF (placental growth factor), or angiopoietins. Considering the important contributions of HIF-1 in angiogenesis and vasculogenesis, it should be considered a promising target for treating ischaemic diseases or cancer. In this review, we discuss the roles of HIF-1 in both physiological/pathophysiological angiogenesis and potential strategies for clinical therapy.

Burn Healing with Binahong (Anredera cordifolia (Tenore) Steenis) Leaves Extract as A Topical and Systemic Treatments

“…Binahong leaves also contain active substances that Quercetin can increase the formation of neovascularization by inhibiting HIF prolylhydrocylase which resulted in activation of HIF-1 (HypoxiaInducible Factor-1) that activates transcriptions of several angiogenic genes and their receptors such as VEGF. VEGF activation will facilitate endothelial cell recruitment in hypoxic sites resulting in increased endothelial cell proliferation by regulating genes involved in cell cycle and DNA replication and ending with stimulation of neovascularization formation [20]. Leaf binahong extract in the wound healing phase plays a role in the hemostasis phase.…”

Hypoxia, Angiogenesis and Atherogenesis

“…Angiogenesis in hypoxia is regulated by several pro-and anti-angiogenic factors [1]. HIF-1 has been established as the major inducer of angiogenesis [35].…”

“…Considering the important contributions of HIF-1 in angiogenesis, it may also be a promising target for treating ischaemic disease [1] and pressure-overload heart failure [45].…”

“…An oxygen supply is essential for normal tissue function, development and homeostasis. The vascular network within the cardiovascular system is essential for the delivery of oxygen, nutrients and other molecules to the tissues of the body [1]. Oxygen availability serves as an important regulator of the cardiovascular system.…”

El canal de potasio dependiente de voltaje Kv10.1 y el cáncer

“…Una propiedad de los tumores sólidos es su estado hipóxico, el cual induce la angiogénesis activando el factor inductor de hipoxia (Hipoxia Inducible Factor, HIF), que a su vez promueve la producción de factores proangiogénicos, como el factor de crecimiento endotelial vascular (Vascular Endotelial Growth Factor, VEGF) (Zimna & Kurpisz, 2015). El aumento de la vascularización incrementa el suministro de oxígeno al tumor, favoreciendo así su crecimiento; es más, el aumento del oxígeno disponible es indispensable para satisfacer el elevado metabolismo de cualquier tumor que crezca rápidamente.…”