2020
DOI: 10.1371/journal.pone.0232357
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Hypoxia-related long noncoding RNAs are associated with varicocele-related male infertility

Abstract: One of the main molecular causes that contributes to varicocele-related male infertility is excess production of reactive oxygen species (ROS). It is believed that hypoxia is an important stimulator of ROS in this condition. Recently, the significant roles of long non-coding RNAs (lncRNAs) in hypoxia response have emerged. Despite the investigation of hypoxia, there is scant information about the role of hypoxia-responding lncRNAs in varicocelerelated male infertility. In the present study, we deduced eight hy… Show more

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Cited by 34 publications
(25 citation statements)
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“…In varicocele-related male infertility, MIR210HG was identified as a hypoxia-related long noncoding RNAs ( 37 ). Similarly, MIR210HG expression was also induced in hypoxic human umbilical vein endothelial cells (HUVECs) ( 38 ) and human proximal tubular epithelial cells (PTECs) ( 39 ).…”
Section: Discussionmentioning
confidence: 99%
“…In varicocele-related male infertility, MIR210HG was identified as a hypoxia-related long noncoding RNAs ( 37 ). Similarly, MIR210HG expression was also induced in hypoxic human umbilical vein endothelial cells (HUVECs) ( 38 ) and human proximal tubular epithelial cells (PTECs) ( 39 ).…”
Section: Discussionmentioning
confidence: 99%
“…Another study found that miR-210 was negatively correlated with the sperm count and seminal inhibin-B expression and may be an invasive biomarker of Sertoli cell damage in varicocoele ( Ma et al, 2021 ). In addition, findings from 25 infertile patients with varicocele and 14 fertile men found that hypoxia related lncRNAs, including MLLT4-AS1 and MIR210HG, showed significantly negative correlations with sperm count and sperm motility ( Ata-Abadi et al, 2020 ) ( Figure 4 ).…”
Section: Potential Mechanisms By Which Hypoxia Causes Male Infertilitymentioning
confidence: 99%
“…A study involving 20 infertile men with varicocele and 20 fertile men showed that the sperm concentration, motility, morphology and sperm DNA integrity of varicocele men were significantly lower than those of fertile men, and molecular markers associated with the hypoxia pathway were significantly higher than those associated with the inflammation pathway, suggesting that hypoxia may be the main cause of infertility ( Ghandehari-Alavijeh et al, 2019 ). Subsequent studies showed that hypoxia-related lncRNA expression is significantly elevated in semen from varicocele patients ( Ata-Abadi et al, 2020 ). Mechanistically, oxidative and heat stress caused by hypoxia or hypoxia-ischemia and HIF-1α mediated germ cell apoptosis or sperm damage may be the main reasons ( Zhang et al, 2016 ; Goren et al, 2017 ; Zhu et al, 2017 ; Samanta et al, 2018 ; Zhao et al, 2019 ).…”
Section: Hypoxic Factors Causing Male Infertilitymentioning
confidence: 99%
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“…The hypotheses assume that the causes may include hypoplasia of the developing male gonad in adolescence, congenital/acquired valve defects, venous obstruction, and anatomical variations [ 8 , 18 , 19 ]. Varicocele-related infertility is an effect of changes in testicular blood flow, including blood reflux and venous pressure, leading to scrotal hyperthermia, testicular hypoxia, endocrine disturbance, reflux and accumulation of toxic metabolites of adrenal or renal origin and testicular atrophy [ 7 , 8 , 20 , 21 , 22 , 23 ]. Moreover, most of these pathologies are linked with abnormal spermatogenesis and testicular oxidative stress (OS) resulting from an imbalance between pro- and antioxidative processes.…”
Section: Introductionmentioning
confidence: 99%