Hypoxic Condition Up-Regulates the Expression of Angiopoietin-2 in ADSCs

Abstract

Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.

Priming with caffeic acid enhances the potential and survival ability of human adipose-derived stem cells to counteract hypoxia

“…In regenerative cell therapy applications, mesenchymal stem cell (MSCs) transplantation is a promising approach due to certain characteristics possessed by the MSCs, it includes multilineage potential of differentiation, the ability to restrain OS, and the release of many different soluble mediators with valuable trophic and immunomodulatory effects [ 6 ]. Stem cells enhance the process of angiogenesis and secrete numerous paracrine factors that efficiently enhance the regeneration process at the wounded area [ 7 , 8 ]. In case of any tissue injury, tissue-resident MSCs participate in tissue regeneration and coordinate with the physiological conditions of the microenvironment of tissue for repairing the damaged tissue.…”