Hypoxic hepatitis and acute liver failure in a patient with newly onset atrial fibrillation and diltiazem infusion

Deng, Wu; Farricielli, Laurie

doi:10.1136/bcr-2013-200573

Cited by 12 publications

(9 citation statements)

References 12 publications

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“…Health services research that informs health care policy, planning and provision was also identified as a key area for future research in the PRISMA workshop [ 9 ]. It is interesting to note that a UK focused consultation for palliative care research demonstrated a greater emphasis on health economic aspects and service delivery [ 31 ]. A rationale for this may be the greater involvement of service funders and providers in the consultation.…”

Section: Discussionmentioning

confidence: 99%

Palliative care research on the island of Ireland over the last decade: a systematic review and thematic analysis of peer reviewed publications

McIlfatrick

Murphy

2013

BMC Palliat Care

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BackgroundAs palliative care research continues to expand across Europe, and the world, questions exist about the nature and type of research undertaken in addition to the research priorities for the future. This systematic review, which is the first stage of a larger scale study to identify the research priorities for palliative care on the island of Ireland, examined palliative care research conducted on the island over the last decade.MethodsA comprehensive search strategy was implemented and strict eligibility criteria were applied in order to identify relevant peer-reviewed journal articles. Inclusion criteria were all of the palliative care studies undertaken on the island of Ireland and published between January 2002 and May 2012. These were assessed in relation to year, setting, sample size, research methodology, and relevant findings.Results412 publications were identified for screening and their abstracts obtained. After eliminating articles that did not meet the inclusion criteria, 151 remained for further analysis. A thematic analysis of 128 studies published between 2006 and 2012 revealed eight core themes: (1) specific groups/populations; (2) services and settings; (3) management of symptoms (physical, psychological, social); (4) bereavement; (5) communication and education; (6) death and dying; (7) spirituality; and (8) complementary and alternative medicine/intervention (CAM). There was an upward trend in the number of publications in palliative care research over the last ten years with over 72% of studies being published within the previous four years. A slightly higher number of studies were quantitative in nature (surveys, questionnaires, standardised assessments) followed by qualitative (individual and focus group interviews, case studies, documentary analysis and retrospective case note reviews), mixed methods, and systematic reviews.ConclusionsWhilst there has been a welcome growth in palliative care research across Ireland, this has largely been needs-based and small scale studies. In contrast, international researchers and decision makers recommend the need for more outcomes focused multidisciplinary research. An examination of palliative care research is an essential first step in seeking to develop future priority areas for further research, highlighting opportunities for future collaboration both nationally and internationally.

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Section: Discussionmentioning

confidence: 99%

Palliative care research on the island of Ireland over the last decade: a systematic review and thematic analysis of peer reviewed publications

McIlfatrick

Murphy

2013

BMC Palliat Care

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“…Liver congestion due to heart failure can also be a contributing factor. In this case of hypoxic hepatitis, the diltiazem infusion was stopped; anticoagulation was held initially because of liver toxicity-induced coagulopathy [ 48 ].…”

Section: Reviewmentioning

confidence: 99%

Gastrointestinal Side Effects of Antiarrhythmic Medications: A Review of Current Literature

Amjad

Qureshi

Farooq

et al. 2017

Cureus

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Antiarrhythmic drugs are commonly prescribed cardiac drugs. Due to their receptor mimicry with several of the gastrointestinal tract receptors, they can frequently lead to gastrointestinal side effects. These side effects are the most common reasons for discontinuation of these drugs by the patients. Knowledge of these side effects is important for clinicians that manage antiarrhythmic drugs. This review focuses on the gastrointestinal side effects of these drugs and provides a detailed up-to-date literature review of the side effects of these drugs. The review provides case reports reported in the literature as well as possible mechanisms that lead to gastrointestinal side effects.

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“…Cardiohepatic interaction has been noted in patients with heart failure [5], atrial fibrillation [6], and myocardial infarction [7]. Although the relationship between aminotransferase levels and cardiovascular disease has become a matter of discussion [8, 9], the prognostic utility of aminotransferase has not been fully studied.…”

Section: Introductionmentioning

confidence: 99%

Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

et al. 2016

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Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up. The AST/ALT ratio increased with increasing BNP levels. And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL). There were 250 all-cause deaths including 79 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without. Conclusions. The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population. Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.

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Hypoxic hepatitis and acute liver failure in a patient with newly onset atrial fibrillation and diltiazem infusion

Cited by 12 publications

References 12 publications

Palliative care research on the island of Ireland over the last decade: a systematic review and thematic analysis of peer reviewed publications

Palliative care research on the island of Ireland over the last decade: a systematic review and thematic analysis of peer reviewed publications

Gastrointestinal Side Effects of Antiarrhythmic Medications: A Review of Current Literature

Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

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