Hypoxic Versus Normoxic External-Beam Irradiation of Cervical Carcinoma Combined with Californium-252 Neutron Brachytherapy

Abstract

The importance of the protective effects of hypoxyradiotherapy for dose escalation in external-beam irradiation of cervical carcinoma, including paraaortic lymph nodes, with regard to an improvement of the cure rates of metastases in paraaortic lymph nodes has been confirmed.

Reoxygenierung humaner koronarer glatter Muskelzellen inhibiert die HIF-1α-Genexpression und steigert die radiogene Wachstumsverzögerung und Apoptose

“…For many years the impact of hypoxia on radiobiological research resulted from its direct role in inducing radiation resistance in tumor cells [8,19,26]. Furthermore, the volume of hypoxic cells in a malignant tumor seems to be a major prognostic factor [6].…”

Phase I/II Trial of External Irradiation plus Medium-Dose Brachytherapy Given Concurrently to Liposomal Doxorubicin and Cisplatin for Advanced Uterine Cervix Carcinoma

“…Controversy exists between definitive radiotherapy (RT) and radical surgery for stage IB and IIB uterine cervical carcinoma. However, the percentage of patients receiving combined surgery and RT (pre-or postoperatively) remains unchanged, as does the thesis that patients with stage IIB, III, and IVA tumors are to be treated with RT alone or with combined chemoradiation [8,23,33,34,40,50]. Local and distant failures are common problems in patients with locally advanced tumors.…”

The munich fission neutron therapy facility MEDAPP at the research reactor FRM II

“…Although the clinical application of neutron therapy has decreased in the last decades, there is still some interest in neutron therapy [12,18,22]. Our biological motivations for the use of neutrons with energies around 2 MeV are their higher relative biological effectiveness and lower oxygen enhancement ratio as compared to higher energetic neutrons and, of course, to low linear energy transfer (LET) radiation [7,10,11,13,15,19].…”