Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary

Gulappa, Thippeswamy; Menon, Bindu; Menon, K.M.J.

doi:10.1016/j.mce.2015.06.014

Cited by 10 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a total of 29 mRNAs were involved in cAMP signaling. cAMP signaling has previously been implicated that it was expressed in mature follicles to maintain oocyte meiosis inhibition in ovarian (Gulappa et al, 2015;Lyga et al, 2016). In particular, the downstream genes of PTCH1, GLI1, HHIP, and AMH were found to be upregulated in small follicles, suggesting that these genes are implicated in Hedgehog and AMH transduction in small follicles.…”

Section: Discussionmentioning

confidence: 96%

Identification of mRNAs and lncRNAs Involved in the Regulation of Follicle Development in Goat

Zhao

Zou

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

Follicular development and maturation has a significant impact on goat reproductive performance, and it is therefore important to understand the molecular basis of this process. The importance of long non-coding RNAs (lncRNAs) in mammalian reproduction has been established, but little is known about the roles of lncRNAs in different follicular stages, especially in goats. In this study, RNA sequencing (RNA-seq) of large follicles (>10 mm) and small follicles (<3 mm) of Chuanzhong black goats was performed to investigate the regulatory mechanisms of lncRNAs and mRNAs in follicular development and maturation. A total of 8 differentially expressed lncRNAs (DElncRNAs) and 1,799 DEmRNAs were identified, and the majority of these were upregulated in small follicles. MRO, TC2N, CDO1, and NTRK1 were potentially associated with follicular maturation. KEGG pathway analysis showed that the DEmRNAs involved in ovarian steroidogenesis (BMP6, CYP11A1, CYP19A1, 3BHSD, STAR, LHCGR, and CYP51A1) and cAMP signaling play roles in regulating follicular maturation and developmental inhibition respectively. Five target pairs of DElncRNA-DEmRNA, namely, ENSCHIT00000001255-OTX2, ENSCHIT00000006005-PEG3, ENSCHIT00000009455-PIWIL3, ENSCHIT00000007977-POMP, and ENSCHIT00000000834-ACTR3 in co-expression analysis provide a clue in follicular development and maturation of lncRNA-mRNA interaction. Our findings provide a valuable resource for lncRNA studies, and could potentially provide a deeper understanding of the genetic basis and molecular mechanisms of goat follicular development and maturation.

show abstract

Section: Discussionmentioning

confidence: 96%

Identification of mRNAs and lncRNAs Involved in the Regulation of Follicle Development in Goat

Zhao

Zou

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Among them, RPL10A, RPL23A, RPL24, RPL34, RPL37, RPLP0, RPS3A , RPS6 and RPS7 are all common protein family ribosomal protein, they play an important role in the development of ovarian and breast cancers related to precocious puberty [38,39]. And EIF5A, HNRNPDL, HSPA8, PKN1, PRKAR2B, SLC40A1, SLC25A5, SNRPD2 and YWHAH, play key roles in oocyte meiosis, steroid biosynthesis and conduction of reproduction process [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Genes Associated With Precocious Puberty by Suppression Subtractive Hybridization in Goat Pituitary Tissues

Cao

Xie

Liu

2020

Preprint

View full text Add to dashboard Cite

Background Our study aimed to identify genes related to precocious puberty expressed in the pituitary of different growth stages goats using suppression subtractive hybridization (SSH) screening. Pituitary tissues at 30 day and 90 day and 180 day growth stages of Jining gray goats and Liaoning cashmere goats were used in this study. To identify differentially expressed genes in the pituitary tissues, mRNA from these tissues was extracted and SSH libraries were constructed for screening (API, EPI and BPI groups). ResultsA total of 60, 49 and 58 differently expression genes were annotation in the database. 222 Gene Ontology (GO) terms and 75 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were matched to those genes. Most differentially expressed genes (DEGs) related to the GO terms “structural constituent of ribosome”, “translation” and “GTP binding” were significantly enriched while numerous DEGs related to the Jak-STAT signaling and oocyte meiosis pathways were also significantly enriched. Candidate genes to be involved in precocious puberty and sexual development were retrieved from the SSH libraries. These related genes were discussed taking into account whether they were expressed in different growth stages of pituitary tissues, and of which them influenced the hypothalamic-pituitary-gonadal (HPG) axis. ConclusionsInteresting findings about precocious puberty related genes from an evolutionary perspective (such as PRLP0, EIF5A and YWHAH) and for putative future goats breeding applications are reported here. We provide a valuable dataset that will facilitate further research into the reproductive biology of goats.

show abstract

“…It has been revealed that eIF5A plays an important role in regulating cellular autophagy. The mRNA level of eIF5A was significantly upregulated after hCG-induced downregulation of LHR, whereas eIF5A level decreased over time, suggesting that eIF5A is involved in the post-transcriptional regulation of ovarian LHR mRNA-binding protein [55]. Therefore, we hypothesized that spermidine mediates hyp-eIF5A modification and regulates ovarian autophagy to inhibit ovarian aging, but in-depth studies are needed to unravel the specific mechanisms.…”

Section: Polyamine Induces Autophagy In Ovariesmentioning

confidence: 99%

Polyamines in Ovarian Aging and Disease

Kang,

Wang,

et al. 2023

IJMS

View full text Add to dashboard Cite

Ovarian aging and disease-related decline in fertility are challenging medical and economic issues with an increasing prevalence. Polyamines are a class of polycationic alkylamines widely distributed in mammals. They are small molecules essential for cell growth and development. Polyamines alleviate ovarian aging through various biological processes, including reproductive hormone synthesis, cell metabolism, programmed cell death, etc. However, an abnormal increase in polyamine levels can lead to ovarian damage and promote the development of ovarian disease. Therefore, polyamines have long been considered potential therapeutic targets for aging and disease, but their regulatory roles in the ovary deserve further investigation. This review discusses the mechanisms by which polyamines ameliorate human ovarian aging and disease through different biological processes, such as autophagy and oxidative stress, to develop safe and effective polyamine targeted therapy strategies for ovarian aging and the diseases.

show abstract

Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary

Cited by 10 publications

References 28 publications

Identification of mRNAs and lncRNAs Involved in the Regulation of Follicle Development in Goat

Identification of mRNAs and lncRNAs Involved in the Regulation of Follicle Development in Goat

Identification of Differentially Expressed Genes Associated With Precocious Puberty by Suppression Subtractive Hybridization in Goat Pituitary Tissues

Polyamines in Ovarian Aging and Disease

Contact Info

Product

Resources

About