Hysteresis Loss of Fractionated Magnetic Nanoparticles for Hyperthermia Application

Sasayama, Teruyoshi; Yonetani, Takashi; Tanabe, K.; Tsujimura, Naotaka; Enpuku, Keiji

doi:10.1109/tmag.2015.2438080

Cited by 16 publications

(8 citation statements)

References 17 publications

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“…In addition, the hysteresis loss is also important for MHT, as increasing the hysteresis loss is improving the heating efficiency (94). A study by Sasayama et al (95) examined the hysteresis loss of magnetically fractionated MNPs for hyperthermia application. They concluded that the efficiency of hyperthermia is improved by magnetically separating MNPs (95).…”

Section: Cancer Treatmentmentioning

confidence: 99%

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Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

2017

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Abstract. In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field. Early diagnosis of cancer may be achieved by MRI, therefore, individualized treatment may be combined with MRI, so as to achieve the precise definition and appropriate treatment. In the present review, research on MNPs in cancer diagnosis, drug delivery and treatment has been summarized. Furthermore, the future perspectives and challenges of MNPs in the field of oncology are also discussed. IntroductionMagnetic nanoparticles (MNPs) are a kind of intelligent nanomagnetic material, with small particle size, large specific surface area, magnetic response and superparamagnetism (1). MNPs may be assembled and positioned under a constant magnetic field, and the heat is absorbed by the electromagnetic wave in the alternating magnetic field. In biomedical applications, MNPs are generally in the superparamagnetic state (2,3). The most frequently used nanomaterial is the iron oxide nanoparticle, including magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ) (4). It is well known that MNPs have an important role in cancer diagnosis, drug delivery and treatment. For cancer diagnosis, tumor imaging technology opened the possibility of early detection of disease. Common imaging modalities include magnetic resonance imaging (MRI) (5), magneto acoustic tomography (MAT) (6), computed tomography (CT) (7) and near-infrared (NIR) imaging (8). Among them, MRI has a strong influence in the early diagnosis of cancer, and superparamagnetic iron oxide nanoparticles (SPIONs) are the most representative as a contrast agent for MRI (9). Currently, certain iron oxide-based MNPs have been approved for use in clinical MRI, for example ferumoxil (GastroMARK) enhances imaging of the bowel (10). Due to the small size and large specific surface area of MNPs, they are able to easily reach the location of the lesion (11). Therefore, MNPs as a drug carrier for drug delivery is an application that cannot be ignored. This property of MNPs is fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field (12). In general, MNPs are used as drug carriers by binding antibodies (13) and chemotherapeutic drugs (14). Commonly, chemotherapeutic drugs are loaded in MNPs, and they are involved in cancer treatment. MNPs in the field of cancer therapy are generally used in several different ways: Chemotherapy; magnetic hyperthermia (MHT) (15); photodynamic therapy (PDT) (16); and photothermal ther...

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Section: Cancer Treatmentmentioning

confidence: 99%

“…A study by Sasayama et al (95) examined the hysteresis loss of magnetically fractionated MNPs for hyperthermia application. They concluded that the efficiency of hyperthermia is improved by magnetically separating MNPs (95). Generally, MHT may enhance the efficacy of chemotherapeutic drugs to some degree.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

2017

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“…This process, in which SPIONs are heated by an AC magnetic field (AMF) that is created by a few hundred (100-400 kHz) frequency AC passing through a solenoid coil, has quickly become an attractive method for various technological and biomedical applications [26,27]. When SPIONs are exposed to AMF inside the solenoid coil, there is a conversion of electromagnetic energy into thermal energy through the mechanisms of Brownian relaxation, N eel relaxation, and hysteresis losses [28][29][30]. The SPION heating efficiency is affected by the applied magnetic field frequency, nanoparticle size, nanoparticle anisotropy, and their collective behavior [31].…”

Section: Introductionmentioning

confidence: 99%

“…Under the AC magnetic field, heat may be generated within the SPIONs through mainly N eel and Brownian relaxations, together with hysteresis losses (Fig. 1(b)) [28][29][30]52].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

Kwizera

Stewart

Mahmud

et al. 2022

Journal of Heat Transfer

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Magnetic nanoparticles, especially superparamagnetic nanoparticles (SPIONs), have attracted tremendous attention for various biomedical applications. Facile synthesis and functionalization together with easy control of the size and shape of SPIONS to customize their unique properties, have made it possible to develop different types of SPIONs tailored for diverse functions/applications. More recently, considerable attention has been paid to the thermal effect of SPIONs for the treatment of diseases like cancer and for nanowarming of cryopreserved/banked cells, tissues, and organs. In this mini-review, recent advances on the magnetic heating effect of SPIONs for magnetothermal therapy and enhancement of cryopreservation of cells, tissues, and organs, are discussed, together with the non-magnetic heating effect (i.e., high Intensity focused ultrasound or HIFU-activated heating) of SPIONs for cancer therapy. Furthermore, challenges facing the use of magnetic nanoparticles in these biomedical applications are presented.

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“…A number of parameters, such as particle size, size distribution, shape, concentration, strength, and duration of activation of the magnetic field, are critical to affecting the heating efficiency of magnetic nanoparticles. While the concepts of both IONP‐enabled hyperthermia and IONP‐enhanced MRI have been investigated for many years, there is not yet a product on the market (Sasayama et al, 2015) and they are still being explored in preclinical stages (Lu et al, 2019; Zhu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Magnetically‐activated lipid nanocarriers in biomedical applications: A review of current status and perspective

Sun

Tan

Boyd

2022

WIREs Nanomed Nanobiotechnol

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Magnetically-activated lipid nanocarriers have become a research hotspot in the field of biomedicine. Liposomes and other lipid-based carriers possess good biocompatibility as well as the ability to carrying therapeutic cargo with a range of physicochemical properties. Previous studies have demonstrated that magnetic materials have potential wide applications in clinical diagnosis and therapy, such as in MRI as contrast agents and in hyperthermic obliteration of cancer tissues. More recently magneto-thermal activation of lipid carriers to

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Hysteresis Loss of Fractionated Magnetic Nanoparticles for Hyperthermia Application

Cited by 16 publications

References 17 publications

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

Magnetically‐activated lipid nanocarriers in biomedical applications: A review of current status and perspective

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