Hysteroscopy findings and its correlation with latent endometrial tuberculosis in infertility

Mohakul, Subrat Kumar; Beela, Venkata Radha Kumari; Tiru, Purnima

doi:10.1007/s10397-014-0865-1

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…(6,9) Several observations made during laparoscopy and hysteroscopy have been mentioned in the published research relevant to FGTB. (6,(10)(11)(12). In addition, treatment with anti-tubercular medication is started once that has been determined to be necessary.…”

Section: Introductionmentioning

confidence: 99%

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Mondal

Jaiswal

Bhave

2023

Preprint

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Background: Currently, none of the diagnostic procedures for detecting female genital tuberculosis (FGTB) are 100 percent reliable, and the same is true for endoscopic results. There are several studies accessible on hysteroscopic and laparoscopic findings that are suggestive of TB. However, no study to our knowledge summarises the findings of laparoscopic and hysteroscopic examination in subfertile female patients with biopsy, culture, or other laboratory test-proven endometrial tuberculosis. Objective: Evaluation of hysteroscopic and laparoscopic findings in subfertile women suffering from proven endometrial tuberculosis. Materials and methods: 16,784 infertile women had a diagnostic hysterolaparoscopy between February 2014 and June 2021, among which 1084 patients were prescribed anti-tubercular medication based on the results of their findings; however, only 309 individuals had endometrial tuberculosis verified via positive on histopathology examination, AFB demonstration, Culture, and GeneXpert MTB/RIF. We retrospectively observed the diagnostic hysterolaparoscopy findings in those proven cases of subfertile women suffering from FGTB. Results: The major findings on hysteroscopy were periosteal fibrosis (209/309,67.63%), pale endometrium(179/309,57.92%), and micro polyp(138/309,44.66%). Other notable hysteroscopic findings were intrauterine adhesions (88/309,28.47%), endometrial tubercle (78/309,25.24%), endometrial polyp(54/309,14.88%), caseation(42/309,13.59%), focal hyperemia(29/309,9.38%) and diffuse hyperemia(18/309,5.82%). The most common finding on laparoscopy was abdominopelvic adhesions of various grades (297/309,96.11%). The major findings of laparoscopy were tubercle (155/309,50.16%), isthmo ampullary block (118/309,38.18%), tubal diverticula (116/309,37.54%), hydrosalpinx (97/309,31.39%) and TO mass (96/309,31.06%). 5.50% (17/300) had a normal appearance on hysteroscopy, and 1.29% (4/309) had a normal-looking pelvis on laparoscopy. Conclusions: In proven endometrial tuberculosis, significant hysteroscopic findings are periosteal fibrosis, pale endometrium, micro-polyp, and intrauterine adhesions, whereas major laparoscopic findings are various grades of abdominal pelvic adhesions, including perihepatic adhesions, miliary tubercle, isthmo ampullary block, tubal diverticula, caseous material, and hydrosalpinx. Tuberculosis should be considered if these signs are discovered during a diagnostic work-up in infertile people.

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Section: Introductionmentioning

confidence: 99%

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Mondal

Jaiswal

Bhave

2023

Preprint

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“…Several observations made during laparoscopy and hysteroscopy have been mentioned in the published research that are relevant to FGTB. [14][15][16][17] This pioneering study explores uncharted territory, delving into laparoscopic and hysteroscopic findings in subfertile women with confirmed FGTB. It seeks to illuminate the diagnostic prowess of these procedures, unveiling tuberculosis-related anatomic and physiological shifts while enhancing diagnostic precision and patient well-being.…”

Section: Introductionmentioning

confidence: 99%

“…Several observations made during laparoscopy and hysteroscopy have been mentioned in the published research that are relevant to FGTB 14–17 . This pioneering study explores uncharted territory, delving into laparoscopic and hysteroscopic findings in subfertile women with confirmed FGTB.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic and hysteroscopic findings in women with sub‐fertility and tuberculosis: A case series

Mondal,

Jaiswal,

Bhave

et al. 2023

BJOG

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ObjectiveEvaluation of hysteroscopic and laparoscopic findings in subfertile women predictive of tuberculosis.DesignRetrospective case series analysis.SettingTertiary hospital in India.PopulationA retrospective analysis of 16 784 subfertile women who had undergone diagnostic hysterolaparoscopy (DHL) was conducted between February 2014 and June 2021.MethodsHistopathological evidence, acid‐fast bacilli (AFB), culture and GeneXpert MTB/RIF assay were used to diagnose female genital tuberculosis (FGTB). Various hysteroscopic and laparoscopic findings were analysed, and a binary logistic regression assessed associations between these findings and positive diagnostic outcomes.Main outcome measuresVarious hysteroscopic and laparoscopic findings correspond to tubercular manifestation.ResultsOf the 16,784 patients, 1083 had hysteroscopy and laparoscopy findings suggestive of tuberculosis, and 309 were diagnosed with FGTB based on diagnostic tests. Logistic regression identified variables strongly predictive of positive status outcomes; tuberculous abdomino‐pelvic adhesions of various grades, isthmo‐ampullary block, tubercle, tubo‐ovarian mass, tuberculous hydrosalpinx, complete tubal destruction, tubal diverticula and rigid tube emerged as strong predictors.ConclusionsLogistic regression‐derived predictors, alongside specific laparoscopic and hysteroscopic findings, can enhance diagnostic accuracy and clinical decision‐making to start antitubercular therapy in subfertile women.

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“…1 The two-third of this global burden presented in eight countries included; India, Indonesia, China, the Philippines, Pakistan, Nigeria, Bangladesh, and South Africa. 1 Female Genital Tuberculosis is commonly secondary to pulmonary TB (PTB) or extrapulmonary TB (EPTB), with the incidence rate ranging between 9 to 20 and 5 to 13 among overall EPTB, 2,3 and PTB, 4,5 cases worldwide 6 , respectively. Typically female genital Tuberculosis (FGTB) is known as the disease of young women (20-40 year-old) 5,7 , and it is usually diagnosed during infertility evaluations.…”

Section: Introductionmentioning

confidence: 99%

“…1 Female Genital Tuberculosis is commonly secondary to pulmonary TB (PTB) or extrapulmonary TB (EPTB), with the incidence rate ranging between 9 to 20 and 5 to 13 among overall EPTB, 2,3 and PTB, 4,5 cases worldwide 6 , respectively. Typically female genital Tuberculosis (FGTB) is known as the disease of young women (20-40 year-old) 5,7 , and it is usually diagnosed during infertility evaluations. 2,8 A previous study indicated that the infertility rates in women is higher compared to men 9 .…”

Section: Introductionmentioning

confidence: 99%

Female Genital Tuberculosis Among Infertile Women and Its Contributions to Primary and Secondary Infertility

Ahmed

Mohammed

Ilesanmi

et al. 2022

Sultan Qaboos Univ Med J

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Female genital tuberculosis (FGTB) is an infectious widespread disease among young women. This meta-analysis study aimed to investigate the prevalence of Female Genital Tuberculosis among infertile women and its contribution to primary and secondary infertility. A PubMed, MEDLINE, world cat log, Lens.org, direct Google search, Google Scholar, and Researchgate, from 1971 to July 17, 2021, were searched using the keywords; prevalence, epidemiology, urogenital tuberculosis, FGTB, infertile women, infertility complaints, and FGTB testing methods. Data extracted and meta-analysis was performed. 42 studies were selected with a total of 30918 infertile women. Of these, the pooled prevalence of FGTB was 20% (15-25%; 95%CI; I2 99.94%), and the prevalence of overall infertility, primary infertility, and secondary infertility among FGTB-population were 88%, 66% and 34%, respectively. The proportion of FGTB is remarkable among infertile women globally. The biggest burden of the disease is presented in the low-income countries followed by the lower middle-income, and upper-middle-income countries.

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Hysteroscopy findings and its correlation with latent endometrial tuberculosis in infertility

Cited by 9 publications

References 12 publications

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Laparoscopic and hysteroscopic findings in women with sub‐fertility and tuberculosis: A case series

Female Genital Tuberculosis Among Infertile Women and Its Contributions to Primary and Secondary Infertility

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