<i>Allium</i>-test as a tool for toxicity testing of environmental radioactive-chemical mixtures

Oudalova, A.; Гераськин, С. А.; Dikareva, Nina S.; Pyatkova, S V

doi:10.1088/1742-6596/784/1/012057

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…AT was recommended as an effective tool for genotoxicity testing in case of combined contamination of environmental compartments with radionuclides and chemical compounds (Oudalova et al 2017).…”

Section: Ionizing Radiation and Radioactive Elementsmentioning

confidence: 99%

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

Firbas²,

et al. 2018

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A general report on the use of the Allium test as cytotoxicological and genotoxicological assay is proposed, with particular emphasis about the standardization of the test in several common applications. The intraspecific variation in Allium cepa has been overlooked, as in most investigations no mention is made about origin and denomination of the onion cultivar used. A standardization of the used material would allow a better generalization of the results, since we cannot be sure that all cultivars would give the same response. A more frequent use of transmission electron microscopy (TEM) investigation is proposed. Even if relatively time consuming and not available in all laboratories, it may help to better understand the mechanism of cytotoxicity, since many morphological characters may appear similar but be arisen from different processes observable only with TEM. About statistical testing, tests other than chi-squared may be used in case of a lower amount of data. The most commonly used statistical tests are the parametric tests ANOVA and Student's t, and the nonparametric tests Kruskal-Wallis and Mann-Whitney U, for analysis of variance. Tests should be used also to assess the minimal sample dimension for obtaining significance, since data collection (microscope observation) appears to be one of the main bottle necks of the test. Also the use of the Allium test for testing liposomes and other nanovectors for drug delivery is proposed, in order to assess the cytotoxicity of these types of medium and the possible increase in cytotoxicity of the associated drug.

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Section: Ionizing Radiation and Radioactive Elementsmentioning

confidence: 99%

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

Firbas²,

et al. 2018

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Genetic toxicity of water contaminated by microcystins collected during a cyanobacteria bloom

Pamplona-Silva

Gonçalves

Marin-Morales

2018

Ecotoxicology and Environmental Safety

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Transfer of ¹³⁷Cs into onion (Allium cepa L.) under conditions of hydroponic model experiment

Godyaeva

Paramonova

Kuzmenkova

2019

IOP Conf. Ser.: Mater. Sci. Eng.

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Allium-test as a tool for toxicity testing of environmental radioactive-chemical mixtures

Cited by 3 publications

References 10 publications

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

Genetic toxicity of water contaminated by microcystins collected during a cyanobacteria bloom

Transfer of ¹³⁷Cs into onion (Allium cepa L.) under conditions of hydroponic model experiment

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Allium-test as a tool for toxicity testing of environmental radioactive-chemical mixtures

Cited by 3 publications

References 10 publications

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

An evaluation for the standardization of theAllium cepatest as cytotoxicity and genotoxicity assay

Genetic toxicity of water contaminated by microcystins collected during a cyanobacteria bloom

Transfer of 137Cs into onion (Allium cepa L.) under conditions of hydroponic model experiment

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Product

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Transfer of ¹³⁷Cs into onion (Allium cepa L.) under conditions of hydroponic model experiment