<i>An Atlas of Neonatal Brain Sonography</i>, 2nd edition

Fitzgerald, Tom

doi:10.1258/ult.2011.011e02

Cited by 1 publication

(2 citation statements)

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“…cPVL was defined as periventricular echolucent cystic lesions, while the severity of IVH was classified into grade I (germinal matrix hemorrhage), II (limited IVH without ventricular dilatation), III (extensive IVH with ventricular dilatation), and periventricular parenchymal hemorrhage (PVH) [7]. Brain ultrasound examinations were performed and interpreted by certified pediatric neurologists using 5.0- and/or 7.5-MHz transducers twice during the first week of life, weekly at 2-4 weeks after birth, and monthly thereafter until discharge.…”

Section: Methodsmentioning

confidence: 99%

“…Approximately 40-70% of cPVL are associated with different grades of intraventricular hemorrhage (IVH) in preterm infants [4,5]. IVH happens mostly within 48-72 h after birth [6] and is graded with increasing severity [7]. Studies have shown that IVH, particularly high-grade, may predispose to cPVL [8,9], and is also a significant predictor of CP [10].…”

Section: Introductionmentioning

confidence: 99%

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Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants

Wang

Lin²,

Tu³

et al. 2016

Neonatology

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Background: Cystic periventricular leukomalacia (cPVL) is the most severe white matter injury and is often associated with intraventricular hemorrhage (IVH) in preterm infants. Objective: The aim of this study was to investigate the prevalence, risk factors and neurodevelopmental outcomes of isolated cPVL and cPVL with low-grade and high-grade IVH in premature infants. Methods: From 2001 to 2012, 9,964 infants with <31 weeks' gestational age (GA) admitted to Taiwan hospitals were enrolled. cPVL was classified into three groups: isolated cPVL, cPVL with low-grade (I/II) IVH, and cPVL with high-grade (III) IVH. Results: Of 7,805 infants with complete ultrasound data, 286 (3.7%) had cPVL. Among the cPVL infants, 93 (32.5%) were isolated, 118 (41.3%) had low-grade IVH and 75 (26.2%) had high-grade IVH. The risk of cPVL with IVH was significantly higher among infants with <27 weeks' GA than those with ≥27 weeks' GA, in contrast to that of isolated cPVL. Using infants without cPVL and IVH as the reference group, the most significant predictor of isolated cPVL was neonatal sepsis (odds ratio 2.39; 95% confidence interval 1.52-3.77), while 5-min Apgar score <5 (2.50; 1.48-4.21) and prolonged mechanical ventilation (2.19; 1.42-3.42) were associated with cPVL with low-grade IVH, and GA <27 weeks (2.63; 1.56-4.42), pneumothorax (3.04; 1.40-6.65) and prolonged mechanical ventilation (3.36; 1.88-6.01) contributed to cPVL with high-grade IVH. cPVL infants with low-grade and high-grade IVH had a higher risk of abnormal neurodevelopmental outcomes than infants with isolated cPVL at the age of 24 months. Conclusions: Isolated cPVL, cPVL with low-grade IVH and cPVL with high-grade IVH had different risk factors and neurodevelopmental outcomes, suggestive of different causal pathways.

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Section: Methodsmentioning

confidence: 99%