<i>Bacillus subtilis</i> variant <i>natto</i> Bacteremia of Gastrointestinal Origin, Japan

Tanaka, Ippei; Kutsuna, Satoshi; Ohkusu, Misako; Kato, T.; Miyashita, Mari; Moriya, Ataru; Ohkusu, Kiyofumi

doi:10.3201/eid2808.211567

Cited by 10 publications

(18 citation statements)

References 6 publications

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“…natto and other species of B. subtilis rarely induce infection; however, there are several reports of infection by B. subtilis subsp. natto, such as bloodstream infections and meningitis in natto consumers 1–3,6 . To our knowledge, this case is the first report of community‐acquired pneumonia via this pathogen.…”

Section: Discussionmentioning

confidence: 75%

“…natto, such as bloodstream infections and meningitis in natto consumers. 1 , 2 , 3 , 6 To our knowledge, this case is the first report of community‐acquired pneumonia via this pathogen. The mechanism of pneumonia is unclear.…”

Section: Discussionmentioning

confidence: 75%

“…However, there have been several reports of severe infections in patients that consume natto caused by B. subtilis subsp. natto , particularly in cases of gastrointestinal perforation or immunocompromised individuals 1–3 . On the contrary, there are no reports of community‐acquired pneumonia in an immunocompetent host.…”

Section: Introductionmentioning

confidence: 99%

“…natto , particularly in cases of gastrointestinal perforation or immunocompromised individuals. 1 , 2 , 3 On the contrary, there are no reports of community‐acquired pneumonia in an immunocompetent host. We report a case of pneumonia and bacteremia caused by B. subtilis subsp .…”

Section: Introductionmentioning

confidence: 99%

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A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Tani,

Takehara,

Ishioka

et al. 2024

Respirology Case Reports

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A 70‐year‐old immunocompetent male with a history of insomnia presented with pneumonia and bacteremia caused by Bacillus subtilis. The patient took benzodiazepines and regularly consumed alcohol and natto (fermented soybeans). Initial antibiotic treatment was not effective, and bronchoalveolar lavage was performed. Bronchoalveolar lavage fluid (BALF) analysis revealed an increased lymphocytes fraction, and B. subtilis was detected in the BALF. Whole‐genome sequencing confirmed the congruence of the genetic sequences between the strain in the blood culture of the patient, BALF, and strain isolated from the consumed natto, confirming B. subtilis subsp. natto as the causative pathogen of pneumonia and bacteremia. Vancomycin followed by levofloxacin and systemic corticosteroid were used to treat the condition. This case highlights community‐acquired pneumonia and bacteremia caused by B. subtilis subsp. natto, particularly in individuals who consume natto.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Tani,

Takehara,

Ishioka

et al. 2024

Respirology Case Reports

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“…The other four described a potential safety concern. In the four papers there were problems related to the identification methodology used (Yeltekin et al, 2022, Fugaban et al, 2022, Tokana et al, 2022, Tanaka et al, 2022. The paper of Yeltekin et al ( 2022) reported a negative effect of B. subtilis infection on trout health but there was no clear link between the infectious agent and the trout affected, making the source attribution unclear.…”

Section: Bacillus Sppmentioning

confidence: 99%

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 18: Suitability of taxonomic units notified to EFSA until March 2023

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2023

EFS2

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The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of microorganisms, intended for use in the food or feed chains, to support the work of EFSA's Scientific Panels. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge and safety concerns. Safety concerns identified for a taxonomic unit (TU) are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. In the period covered by this Statement, no new information was found that would change the status of previously recommended QPS TUs. Of 38 microorganisms notified to EFSA between October 2022 and March 2023 (inclusive) (28 as feed additives, 5 as food enzymes, food additives and flavourings, 5 as novel foods), 34 were not evaluated because: 8 were filamentous fungi, 4 were Enterococcus faecium and 2 were Escherichia coli (taxonomic units that are excluded from the QPS evaluation) and 20 were taxonomic units (TUs) that already have a QPS status. Three of the other four TUs notified within this period were evaluated for the first time for a possible QPS status: Anaerobutyricum soehngenii, Stutzerimonas stutzeri (former Pseudomonas stutzeri) and Nannochloropsis oculata. Microorganism strain DSM 11798 has also been notified in 2015 and as its taxonomic unit is notified as a strain not a species, it is not suitable for the QPS approach. A. soehngenii and N. oculata are not recommended for the QPS status due to a limited body of knowledge of its use in the food and feed chains. S. stutzeri is not recommended for inclusion in the QPS list based on safety concerns and limited information about the exposure of animals and humans through the food and feed chains.

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Metagenomics and metagenome-assembled genomes analysis of sieng, an ethnic fermented soybean food of Cambodia

Tamang,

Kharnaior,

Das

et al. 2023

Food Bioscience

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Bacillus subtilis variant natto Bacteremia of Gastrointestinal Origin, Japan

Cited by 10 publications

References 6 publications

A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 18: Suitability of taxonomic units notified to EFSA until March 2023

Metagenomics and metagenome-assembled genomes analysis of sieng, an ethnic fermented soybean food of Cambodia

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